Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of pyrazinamide on the metabolism of tryptophan to niacin and of tryptophan to serotonin were investigated to elucidate the mechanism for pyrazinamide action against tuberculosis. Weanling rats were fed with a diet with or without 0.25% pyrazinamide for 61 days. Urine samples were periodically collected for measuring the tryptophan metabolites. The administration of pyrazinamide significantly increased the metabolites, 3-hydroxyanthranilic acid and beyond, especially quinolinic acid, nicotinamide, N^1-methylnicotinamide, and N^1-methyl-4-pyridone-3-carboxamide, and therefore significantly increased the conversion ratio of tryptophan to niacin and the blood NAD level . However, no difference in the upper metabolites of the tryptophan to niacin pathway such as anthranilic acid, kynurenic acid and xanthurenic acid was apparent between the two groups. No difference in the concentrations of trytptophan and serotonin in the blood were apparent either. It is suggested from these results that the action of pyrazinamide against tuberculosis is linked to the increase in turnover of NAD and to the increased content of NAD in the host cells.
- 社団法人日本農芸化学会の論文
- 2001-06-23
著者
-
Shibata Katsumi
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
-
Shibata Katsumi
Course Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures The U
-
FUKUWATARI Tsutomu
Course of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, Th
-
SUGIMOTO Etsuro
Course of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, Th
-
Sugimoto E
Univ. Shiga Prefecture Shiga Jpn
-
Fukuwatari Tsutomu
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
-
Fukuwatari Tsutomu
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
関連論文
- Effect of Fasting on the Urinary Excretion of Water-Soluble Vitamins in Humans and Rats
- Effects of Fatty Liver Induced by Niacin-free Diet with Orotic Acid on the Metabolism of Tryptophan to Niacin in Rats(Food & Nutrition Science)
- Influence of Adenine-induced Renal Failure on Tryptophan-niacin Metabolism in Rats(Food & Nutrition Science)
- Urinary Excretory Ratio of Anthranilic Acid/Kynurenic Acid as an Index of the Tolerable Amount of Tryptophan
- Apoptosis Induced by Niacin-Related Compounds in K562 Cells but not in Normal Human Lymphocytes
- Apoptosis Induced by Nicotinamide-related Compounds and Quinolinic Acid in HL-60 Cells
- Intra- and Inter-Individual Variations of Blood and Urinary Water-Soluble Vitamins in Japanese Young Adults Consuming a Semi-Purified Diet for 7 Days
- Age-Related Alterations of B-Group Vitamin Contents in Urine, Blood and Liver from Rats
- Comparison of the Effects of Di(2-ethylhexyl)phthalate, a Peroxisome Proliferator, on the Vitamin Metabolism Involved in the Energy Formation in Rats Fed with a Casein or Gluten Diet
- Comparison of Metabolic Fates of Nicotinamide, NAD^+ and NADH Administered Orally and Intraperitoneally; Characterization of Oral NADH
- Effects of Excess Pantothenic Acid Administration on the Other Water-Soluble Vitamin Metabolisms in Rats
- Values of Water-Soluble Vitamins in Blood and Urine of Japanese Young Men and Women Consuming a Semi-Purified Diet Based on the Japanese Dietary Reference Intakes
- The Necessity of Niacin in Rats Fed on a High Protein Diet
- Changes in the Urinary Excretion of the Metabolites of the Trytophan-Niacin Pathway during Pregnancy in Japanese Women and Rats
- Conversion Ratio of Tryptophan to Niacin in Japanese Women Fed a Purified Diet Conforming to the Japanese Dietary Reference Intakes
- Effects of Excess Nicotinamide Administration on the Urinary Excretion of Nicotinamide N-Oxide and Nicotinuric Acid by Rats
- Effects of Dietary Di(2-ethylhexyl) phthalate on the Metabolism of Tryptophan to Niacin in Mice
- Vitamin Intake in Japanese Women College Students
- Identification of a Toxic Mechanism of the Plasticizers, Phtahlic Acid Esters, which are Putative Endocrine Disrupters : Time-dependent Increase in Quinolinic Acid and Its Metabolites in Rats Fed di (2-ethylhexyl) phthalate(Food & Nutrition Science)
- Effects of Stress on the Urinary Excretory Pattern of Niacin Catabolites, the Most Reliable Index of Niacin Status, in Humans
- Growth-promoting Activity of Pyrazinoic Acid, a Putative Active Compound of Antituberculosis Drug Pyrazinamide, in Niacin-deficient Rats through the Inhibition of ACMSD Activity(Food & Nutrition Science)
- Elucidation of the Toxic Mechanism of the Plasticizers, Phthalic Acid Esters, Putative Endocrine Disrupters : Effects of Dietary Di(2-ethylhexyl)phthalate on the Metabolism of Tryptophan to Niacin in Rats(Food & Nutrition Science)
- Changes of Pyridine Nucleotide Levels during Adipocyte Differentiation of Mouse 3T3-L1 Cells(Biochemistry & Molecular Biology)
- Effect of Dietary Histidine Content on the Change in Content of Skin Urocanic Acid Isomers in Hairless Mice Irradiated with Ultraviolet B
- Characteristic and Localization of the Monitor Peptide Receptor
- Elevation of Blood NAD Level after Moderate Exercise in Young Women and Mice
- High-Fat Diet Lowers the Nutritional Status Indicators of Pantothenic Acid in Weaning Rats
- Comparison of the Nicotinamide Catabolism among Rat Strains
- Molybdenum and Chromium Concentrations in Breast Milk from Japanese Women
- Urinary Excretory Ratio of Anthranilic Acid/Kynurenic Acid as an Index of the Tolerable Amount of Tryptophan
- Fluorometric Determination of 2-Oxoadipic Acid, a Common Metabolite of Tryptophan and Lysine, by High-Performance Liquid Chromatography with Pre-Chemical Derivatization
- Vitamin Contents in Rat Milk and Effects of Dietary Vitamin Intakes of Dams on the Vitamin Contents in Their Milk
- Recognition System for Dietary Fatty Acids in the Rat Small Intestine
- The Recognition System of Dietary Fatty Acids by the Rat Small Intestinal Cells
- Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats
- Increased Conversion Ratio of Tryptophan to Niacin by Dietary Di-n-butylphthalate
- Efficiency of D-Tryptophan as Niacin in Rats
- High-performance liquid chromatographic measurement of urocanic acid isomers and their ratios in naturally light-exposed skin and naturally shielded skin
- Effects of Exercise on the Metabolism of NAD in Rats
- Fluorometric determination of pantothenic acid in human urine by isocratic reversed-phase ion-pair high-performance liquid chromatography with post-column derivatization
- Vitamin Intake in Japanese Women College Students
- Effects of Stress on the Urinary Excretory Pattern of Niacin Catabolites, the Most Reliable Index of Niacin Status, in Humans
- Urinary Excretion of Water-Soluble Vitamins Increases in Streptozotocin-Induced Diabetic Rats without Decreases in Liver and Blood Vitamin Content
- The Urinary Excretory Ratio of Nicotinamide Catabolites Was Associated with the Conversion Ratio of Tryptophan to Nicotinamide in Growing Rats Fed a Niacin-Free 20% Casein Diet