Comparison of the Nicotinamide Catabolism among Rat Strains
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概要
- 論文の詳細を見る
We discovered markedly differing catabolism of nicotinamide among rat strains. We compared the catabolism of nicotinamide and also that of the other tryptophan-nicotinamide and water-soluble vitamins among the four strains, Wistar, Sprague-Dawley (SD), August-Copenhagen Irish (ACI) and Fischer 344. The major urinary catabolite of nicotinamide was N1-methyl-4-pyridone-3-carboxamide in Wistar, SD and ACI, and N1-methylnicotinamide in Fischer rats. This phenomenon was attributed to the enzyme activity involved in the reaction of N1-methylnicotinamide to N1-methyl-4-pyridone-3-carboxamide being much lower in Fischer than in the other three strains. With the water-soluble vitamins, this specific phenomenon was only observed in the catabolism of vitamin B6; the urinary catabolite, 4-pyridoxic acid, was much lower too. It was found for the first time that the activities of oxidase were lower in Fischer than in the other strains. This study showed that Wistar, SD, ACI strains had similar water-soluble vitamin metabolism including nicotinamide catabolism.
- 社団法人 日本農芸化学会の論文
- 2009-02-23
著者
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FUKUWATARI Tsutomu
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
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TAKAHASHI Kei
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
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SHIBATA Katsumi
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
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Shibata Katsumi
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
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Shibata Katsumi
Course Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures The U
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Shibata Katsumi
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Takahashi Kei
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Okuno Alato
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
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Fukuwatari Tsutomu
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
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Takahashi Kei
Department Of Electrical And Electronic Engineering National Defense Academy
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Fukuwatari Tsutomu
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Okuno Alato
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Shibata Katsumi
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
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Fukuwatari Tsutomu
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
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Takahashi Kei
Department of Applied Chemistry, School of Science and Engineering, Waseda University
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