Age-Related Alterations of B-Group Vitamin Contents in Urine, Blood and Liver from Rats
スポンサーリンク
概要
- 論文の詳細を見る
To investigate how aging alters B-group vitamin metabolism, rats were fed with niacin-free 20% casein diet from 3 to 80wk old, and the urinary excretions of the B group vitamins were periodically measured. The blood and liver B-group vitamin levels in 80-wk-old rats were also compared with those in 8-wk-old rats. The urinary excretion of thiamin, riboflavin, vitamin B_6 metabolite 4-pyridoxic acid, pantothenic acid, folic acid and biotin were not altered during 540d. The urinary vitamin B_12 increased by 8-fold at 29wk old, and further increased at 80wk old. Conversion of nicotinamide from tryptophan gradually decreased to 60% from 29 to 48wk old. Plasma PLP, vitamin B_12 and folate levels in 80-wk-old rats were lower than those in 8-wk-old rats, consistent with lower liver vitamin B_6 and folate levels in aged rats. Plasma and liver biotin levels in aged rats were higher than those in young rats. Other B-group vitamins such as vitamin B_1, vitamin B_2, niacin and pantothenic acid levels in blood and liver from aged rats were same as those from young rats. Alteration of vitamin B_6 metabolism in particular is similar to the observations in eldery humans reported previously. Our findings suggest that aged rats can be useful models to investigate aging-related B-group vitamin metabolism.
- 日本ビタミン学会の論文
著者
-
FUKUWATARI Tsutomu
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
-
SHIBATA Katsumi
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
-
Shibata Katsumi
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
-
Shibata Katsumi
Course Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures The U
-
Shibata Katsumi
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
-
WADA Hideko
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
-
Wada Hideko
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
-
Fukuwatari Tsutomu
Dep. Of Food Sci. And Nutrition School Of Human Cultures The Univ. Of Shiga Prefecture
-
Fukuwatari Tsutomu
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
-
Shibata Katsumi
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
-
Fukuwatari Tsutomu
Laboratory Of Food Science And Nutrition Department Of Lifestyle Studies School Of Human Cultures Th
関連論文
- Effect of Fasting on the Urinary Excretion of Water-Soluble Vitamins in Humans and Rats
- Fluorometric determination of 2-oxoadipic acid, a common metabolite of tryptophan and lysine, by high-performance liquid chromatography with pre-chemical derivatization
- Fluorometric Determination of 2-Oxoadipic Acid, a Common Metabolite of Tryptophan and Lysine, by High-Performance Liquid Chromatography with Pre-Chemical Derivatization
- Effects of Dietary 6-Aminonicotinamide, an Antagonist of Nicotinamide, on the Metabolism of Tryptophan to Nicotinamide in Rats
- High-performance Liquid Chromatographic Measurement of Nicotinamide N-Oxide in Urine after Extracting with Chloroform(Analytical Chemistry)
- Effects of Fatty Liver Induced by Niacin-free Diet with Orotic Acid on the Metabolism of Tryptophan to Niacin in Rats(Food & Nutrition Science)
- Influence of Adenine-induced Renal Failure on Tryptophan-niacin Metabolism in Rats(Food & Nutrition Science)
- Effects of High-voltage Electric Field Treatment on the Water Activity of Bread
- Urinary Excretion of Nicotinamide and Its Metabolites in Alloxandiabetic Rats Fed on a Niacin-free Diet(Food & Nutrition)
- Effects of Ethanol Feeding and Growth on the Tryptophan-niacin Metabolism in Rats(Food & Nutrition)
- Urinary Excretory Ratio of Anthranilic Acid/Kynurenic Acid as an Index of the Tolerable Amount of Tryptophan
- Effects of Peroxidation Products of Linoleic Acid on Tryptophan-nicotinamide Metabolism in Rats
- Effect of Lipid Peroxidation Products on the Catabolic Fate of Nicotinamide in Rats(Food & Nutrition)
- Apoptosis Induced by Niacin-Related Compounds in K562 Cells but not in Normal Human Lymphocytes
- Apoptosis Induced by Nicotinamide-related Compounds and Quinolinic Acid in HL-60 Cells
- Relative Activity of N-(β-D-Glucopyranosyl)nicotinic Acid to Nicotinic Acid as a Niacin Nutrient in Rats and in Lactobacillus plantarum ATCC 8014
- End Product Inhibition of the Activity of Nicotinamide Phosphoribosyltransferase from Various Tissues of Rats by NAD(Biological Chemistry)
- Comparison of Tryptophan-nicotinamide Metabolism between Male and Female Rats
- Efficiency of Dietary 3-Acetylpyridine, Pyridine-3-aldehyde, Pyridine-3-methanol, and β-Picoline as Niacin in Rats
- Comparison of the Nicotinamide Catabolism among Rat Strains
- Intra- and Inter-Individual Variations of Blood and Urinary Water-Soluble Vitamins in Japanese Young Adults Consuming a Semi-Purified Diet for 7 Days
- Age-Related Alterations of B-Group Vitamin Contents in Urine, Blood and Liver from Rats
- Comparison of the Effects of Di(2-ethylhexyl)phthalate, a Peroxisome Proliferator, on the Vitamin Metabolism Involved in the Energy Formation in Rats Fed with a Casein or Gluten Diet
- Comparison of Metabolic Fates of Nicotinamide, NAD^+ and NADH Administered Orally and Intraperitoneally; Characterization of Oral NADH
- Effects of Excess Pantothenic Acid Administration on the Other Water-Soluble Vitamin Metabolisms in Rats
- Values of Water-Soluble Vitamins in Blood and Urine of Japanese Young Men and Women Consuming a Semi-Purified Diet Based on the Japanese Dietary Reference Intakes
- The Necessity of Niacin in Rats Fed on a High Protein Diet
- Changes in the Urinary Excretion of the Metabolites of the Trytophan-Niacin Pathway during Pregnancy in Japanese Women and Rats
- Conversion Ratio of Tryptophan to Niacin in Japanese Women Fed a Purified Diet Conforming to the Japanese Dietary Reference Intakes
- Effects of Excess Nicotinamide Administration on the Urinary Excretion of Nicotinamide N-Oxide and Nicotinuric Acid by Rats
- Effects of Dietary Di(2-ethylhexyl) phthalate on the Metabolism of Tryptophan to Niacin in Mice
- Vitamin Intake in Japanese Women College Students
- Identification of a Toxic Mechanism of the Plasticizers, Phtahlic Acid Esters, which are Putative Endocrine Disrupters : Time-dependent Increase in Quinolinic Acid and Its Metabolites in Rats Fed di (2-ethylhexyl) phthalate(Food & Nutrition Science)
- Effects of Stress on the Urinary Excretory Pattern of Niacin Catabolites, the Most Reliable Index of Niacin Status, in Humans
- Growth-promoting Activity of Pyrazinoic Acid, a Putative Active Compound of Antituberculosis Drug Pyrazinamide, in Niacin-deficient Rats through the Inhibition of ACMSD Activity(Food & Nutrition Science)
- Elucidation of the Toxic Mechanism of the Plasticizers, Phthalic Acid Esters, Putative Endocrine Disrupters : Effects of Dietary Di(2-ethylhexyl)phthalate on the Metabolism of Tryptophan to Niacin in Rats(Food & Nutrition Science)
- Changes of Pyridine Nucleotide Levels during Adipocyte Differentiation of Mouse 3T3-L1 Cells(Biochemistry & Molecular Biology)
- Effect of Dietary Histidine Content on the Change in Content of Skin Urocanic Acid Isomers in Hairless Mice Irradiated with Ultraviolet B
- Nutritional Efficiency of Nicotinamide N-Oxide and N'-Methylnicotinamide as Niacin in Rats(Food & Nutrition)
- Changes in Nicotinamide Metabolism by One Amino Acid Deficiency. (II) Isoleucine-, Phenylalanine-, Valine-, Arginine-, or Histidine-free Diet
- Changes in Nicotinamide Metabolism by One Amino Acid Deficiency. (I) Threonine-, Tryptophan-, Aspartic Acid-, Lysine-, Leucine-, or Methionine-free Diet
- Effects of Protein-Free Diet Feeding or Starving on the Excretion Ratio of (N^1-Methyl-2-pyridone-5-carboxamide + N^1-Methyl-4-pyridone-3-carboxamide)/N^1-Methylnicotinamide(Food & Nutrition)
- Effects of UVA Irradiation on the Concentration of Folate in Human Blood
- Tryptophan-Niacin Metabolism in Liver Cirrhosis Rat Caused by Carbon Tetrachloride
- The Formation of Nicotinamide by Administration of Di(2-ethylhexyl)phthalate Does Not Cause Growth Retardation in Young Rats in Contrast with Excess Exogenous Administration of Nicotinamide
- Comparison of Tryptophan-Niacin Conversion in Rats Fed with a Nicotinic Acid-free Diet Containing Egg White, Egg White Proteolysate, or Mixtures of Amino Acids(Food & Nutrition)
- Consideration of Diurnal Variations in Human Blood NAD and NADP Concentrations
- Urinary Water-Soluble Vitamins and Their Metabolite Contents as Nutritional Markers for Evaluating Vitamin Intakes in Young Japanese Women
- Effect of Pyridoxal on the Urinary Excretion of Nicotinamide Metabolites in Rats(Biological Chemistry)
- Effect of Prednisolone on the Urinary Excretion of Nicotinamide and Its Metabolites in Rats Fed with a Niacin-free Diet(Food & Nutrition)
- High-performance Liquid Chromatographic Measurement of Tryptophan in Blood, Tissues, Urine, and Foodstuffs with Electrochemical and Fluorometric Detections(Analytical Chemistry)
- Effects of Dietary Pyrazinamide on the Growth of Weanling Rats Fed with a Nicotinic Acid-free and Tryptophan-limited Diet(Food & Nutrition)
- Relationship between Urinary Excretion of Kynurenic Acid and Protein Intake in Rats(Food & Nutrition)
- Measurement of 3-Hydroxyanthranilic Acid and Anthranilic Acid in Urine by High-performance Liquid Chromatography(Analytical Chemistry)
- Comparison between the Metabolic Fate of Physiological Amount of Dietary Nicotinic Acid and Nicotinamide in Rats(Food & Nutrition)
- Serotonin Levels in Blood and Small Intestine as Influenced by Nicotinic Acid and Quinolinic Acid(Food & Nutrition)
- Fates of N'-Methylnicotinamide and Nicotinamide N-Oxide in Mice(Food & Nutrition)
- Effects of Pyrazinamide on Tryptophan-Niacin Conversion in Rats(Biological Chemistry)
- Effects of Three Kinds of Dietary Nitrogen Sources on the Metabolic Fate of Tryptophan(Food & Nutrition)
- Elevation of Blood NAD Level after Moderate Exercise in Young Women and Mice
- Effects of Thyroxine on the Conversion Ratio of Tryptophan to Nicotinamide in Rats
- Effects of Sex Hormones on the Metabolism of Tryptophan to Niacin and to Serotonin in Male Rats
- Course of the Urinary Excretion of Nicotinic Acid and Its Related Compounds Following the Injection of Optimal Amount of Nicotinic Acid for NAD Synthesis(Biological Chemistry)
- Increased Conversion Ratio of Tryptophan to Niacin by the Administration of Clofibrate, a Hypolipidemic Drug, to Rats
- In Vivo Inhibition of Kynurenine Aminotransferase Activity by Isonicotinic Acid Hydrazide in Rats
- High-Fat Diet Lowers the Nutritional Status Indicators of Pantothenic Acid in Weaning Rats
- Comparison of the Nicotinamide Catabolism among Rat Strains
- Molybdenum and Chromium Concentrations in Breast Milk from Japanese Women
- Urinary Excretory Ratio of Anthranilic Acid/Kynurenic Acid as an Index of the Tolerable Amount of Tryptophan
- Effects of Progesterone and Estrone on the Conversion of Tryptophan to Nicotinamide in Rats
- Effects of Feeding Tryptophan-limiting Diets on the Conversion Ratio of Tryptophan to Niacin in Rats
- Increased Conversion Ratio of Tryptophan to Niacin in Severe Food Restriction
- Effects of Dietary Pyrazinamide on the Metabolism of Tryptophan to Niacin in Streptozotocin-diabetic Rats
- Fluorometric Determination of 2-Oxoadipic Acid, a Common Metabolite of Tryptophan and Lysine, by High-Performance Liquid Chromatography with Pre-Chemical Derivatization
- Vitamin Contents in Rat Milk and Effects of Dietary Vitamin Intakes of Dams on the Vitamin Contents in Their Milk
- Change in the Ratio of N^1-Methyl-2-pyridone-5-carboxamide to N^1-Methyl-4-pyridone-3-carboxamide Excretion Following a Large Amount of N^1-Methylnicotinamide Injection in Rats(Food & Nutrition)
- Effects of Gradually Increasing Levels of Nicotinamide in a Niacin-free and Tryptophan-limited Diet on the Blood NAD levels and the Urinary Excretion of Nicotinamide Metabolites in Rats(Food & Nutrition)
- Inhibition of N^1-Methylnicotinamide Oxidase Activity by a Large Amount of N^1-Methylnicotinamide Injected into Rats(Food & Nutrition)
- Effect of Dietary Soy Protein Isolate Level on the Ratio of N^1-Methyl-2-pyridone-5-carboxamide plus N^1-Methyl-4-pyridone-3-carboxamide to N^1-Methylnicotinamide Excretion in Rats(Food & Nutrition)
- Inhibition of N^1-Methylnicotinamide Oxidase Activity by a Large Nicotinamide Injection into Rats(Biological Chemistry)
- Effect of the Addition of Free Tryptophan to a 20% Casein Diet on the Ratio of N^1-Methyl-2-pyridone-5-carboxamide plus N^1-Methyl-4-pyridone-3-carboxamide to N^1-Methylnicotinamide Excretion(Food & Nutrition)
- Effects of Vitamin B_6 Deficiency on the Conversion Ratio of Tryptophan to Niacin
- Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats
- Increased Conversion Ratio of Tryptophan to Niacin by Dietary Di-n-butylphthalate
- Efficiency of D-Tryptophan as Niacin in Rats
- High-performance liquid chromatographic measurement of urocanic acid isomers and their ratios in naturally light-exposed skin and naturally shielded skin
- Effects of Exercise on the Metabolism of NAD in Rats
- Fluorometric determination of pantothenic acid in human urine by isocratic reversed-phase ion-pair high-performance liquid chromatography with post-column derivatization
- Fate of Nicotinamide Differs Due to an Intake of Nicotinamide
- Effects of UVA Irradiation on the Concentration of Folate in Human Blood
- The Formation of Nicotinamide by Administration of Di (2-ethylhexyl) phthalate Does Not Cause Growth Retardation in Young Rats in Contrast with Excess Exogenous Administration of Nicotinamide
- Effects of Dietary Protein Levels on the Enzyme Activities Involved in Tryptophan-Niacin Metabolism in Rats(Food & Nutrition)
- Effect of Dietary Paraquat on the Enzyme Activities Involved in Tryptophan-Niacin Metabolism in Rats(Biological Chemistry)
- Vitamin Intake in Japanese Women College Students
- Effects of Stress on the Urinary Excretory Pattern of Niacin Catabolites, the Most Reliable Index of Niacin Status, in Humans
- Simultaneous High-performance Liquid Chromatographic Measurement of Xanthurenic Acid and 3-Hydroxyanthranilic Acid in Urine
- Changes in the Conversion Rate of Tryptophan-nicotinamide According to Dietary Fat and Protein Levels
- Effects of Adrenalin on the Conversion Ratio of Tryptophan to Niacin in Rats
- Effect of Adding Branched-chain Amino Acids to a Nicotinic Acid-free, Low-protein Diet on the Conversion Ratio of Tryptophan to Nicotinamide in Rats
- The Urinary Excretory Ratio of Nicotinamide Catabolites Was Associated with the Conversion Ratio of Tryptophan to Nicotinamide in Growing Rats Fed a Niacin-Free 20% Casein Diet