Beta-Mannosyl Linkages Negatively Regulate Anaphylaxis and Vasculitis in Mice, Induced by CAWS, Fungal PAMPs Composed of Mannoprotein-Beta-Glucan Complex Secreted by Candida albicans(Highlighted paper selected by Editor-in-chief,Microbiology)
スポンサーリンク
概要
- 論文の詳細を見る
Candida albicans water soluble fraction (CAWS) is a water-soluble extracellular mannoprotein-beta-glucan complex obtained from the culture supernatant of Candida albicans, which grows in a chemically defined medium. CAWS induced toxic reactions, such as acute anaphylactoid reaction, by intravenous administration and coronary arteritis by intraperitoneal administration. To clarify the structure responsible for these toxic reactions, C. albicans was cultured in pH- and temperature-controlled conditions and prepared with CAWS with or without the beta-1, 2-linked mannosyl segment (BM). The structure of CAWS was assessed by immunochemical and spectroscopic methodologies, and we found that CAWS prepared under the natural culture conditions contained only small amounts of BM and CAWS prepared at neutral conditions at 27℃ contained a significantly higher percentage of BM. Both the acute lethal toxicity and coronary arteritis induction was significantly more severe in the absence of BM. Activation of a complement pathway, the lectin pathway, by CAWS was significantly stronger in the absence of BM. These facts strongly suggest that BM linkages in CAWS negatively modulate acute and chronic toxicity of CAWS, and may be strongly related to the lectin pathway of the complement activation.
- 社団法人日本薬学会の論文
- 2006-09-01
著者
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TAKAHASHI Kei
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
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SUZUKI Kazuo
Department of Immunology, Inflammatory Program, Chiba University School of Medicine
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三浦 典子
東京薬科大学免疫学
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Naoe shiro
Department of Pathology, Toho University Ohashi Hospital
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Manabe Noriyoshi
International Clinical Research Center Research Institute International Medical Center Of Japan
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NAGI-MIURA Noriko
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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ADACHI Yoshiyuki
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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ISHIBASHI Ken-ichi
Laboratory for Nanoelectronics and Spintronics, Research Institute of Electrical Communication, Toho
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno Naohito
Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miura N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Nagi-miura Noriko
東京薬科大学 薬学部免疫学
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Nagi Miura
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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SHINOHARA Hiroyasu
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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ISHIDA-OKAWARA Akiko
Department of Bioactive Molecules, National Institute of Infectious Diseases
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OHARASEKI Toshiaki
Department of Pathology, Ohashi Hospital, Toho University School of Medicine
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Ishida-okawara Akiko
Dep. Of Bioactive Molecules National Inst. Of Infectious Diseases
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Ishida-okawara Akiko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Ishibashi Ken-ichi
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Naoe S
Department Of Pathology Toho University Ohashi Hospital
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Naoe Shiro
Department Of Pathology Ohashi Hospital Toho University School Of Medicine
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Takahashi Kei
Department Of Pathology Toho University Ohashi Medical Center
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Oharaseki Toshiaki
Department Of Pathology Toho University Ohashi Medical Center
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Shinohara Hiroyasu
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Tokyo College Of Pharmacy:the Tokyo Metropolitan Research Laboratory Of Public Health
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Suzuki Kazuo
Inflammation Program Department Of Immunology Chiba University Graduate School Of Medicine
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Ohno N
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Suzuki Kazuo
Department Of Hamamatsu University School Of Medicine
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Takahashi Kei
Department Of Electrical And Electronic Engineering National Defense Academy
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Ishibashi Ken-ichi
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Nagi Miura
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Suzuki Kazuo
Department Of Immunology Chiba University Graduate School Of Medicine Inflammation Program
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Suzuki Kazuo
Departmens Of Oral Histology Matsumoto Dental College
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Takahashi Kei
Department of Applied Chemistry, School of Science and Engineering, Waseda University
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