Sensitization of Ca^<2+> -dependent K^+ -channels in Guinea-pig Pancreatic Acinar Cells by Phosphorylation
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概要
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The effects of adenosine 3', 5'-cyclic monophosphate (cAMP)-dependent protein phosphorylation on Ca^<2+>-sensitivity of Ca^<2+>-dependent K^+-channels in guinea-pig pancreatic acinar cells were studied by patch-clamp single-channel methods. When opening of the channels did not occur in excised inside-out membrane patches exposed to 10^<-6> M Ca^<2+>, the addition of 25 U/ml catalytic units of cAMP-dependent protein kinase (PKA) to the bath solution opened the channels, with a conductance of 30 pS (in symmetrical K^+ -rich solution). The addition of a PKA-inhibitor (100 μM) extinguished the PKA-dependent opening of the K^+ -channels. Alkaline phosphatase (5 U/ml) reversed the PKA-dependent opening of the K^+ -channels to control levels (before PKA). These results demonstrate that cAMP-dependent protein phosphorylation initiates the Ca^<2+>-sensitivity of the Ca^<2+>-dependent K^+ -channels in guinea-pig pancreatic acinar cells.
- 東海大学の論文
著者
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SUZUKI Kazuo
Department of Immunology, Inflammatory Program, Chiba University School of Medicine
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Suzuki K
Tokai Univ.
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Suzuki Kazuo
Department Of Bio-medical Engineering School Of High-technology For Human Welfare Tokai University
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Suzuki Kazuo
Departmens Of Oral Histology Matsumoto Dental College
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