Non-genomic action of 17 β-estradiol on opening of Ca^<2+> - and voltage-activated K^+ channel in lacrimal acinar cells
スポンサーリンク
概要
- 論文の詳細を見る
The effect of the sex hormone 17 β-estradiol on the opening of Ca^<2+> - and voltage-activated K^+ channels (BK channels) in the basolateral plasma membrane of mouse lacrimal acinar cells was studied by patch-clamp single-channel recording and Ca^<2+> -measurement using fura-2 AM. In intact cells (the cell-attached configuration) using a pipette containing a Na^+ -rich solution, estradiol was added to the bath solution, which does not have direct contact with the electrically isolated areas of membrane patch from which the single-channel currents were recorded. Estradiol increased the frequency of opening of the BK channels within a few minutes after its application. The effect of estradiol on the opening of the BK channels in acinar cells in male mice was greater than that in females. In Ca^<2+> -measurement using fura-2 AM, estradiol did not increase the level of intracellular Ca^<2+> during a 5-minute observation period. The application of estradiol with propranolol, a β-adrenergic receptor blocker, did not increase BK channel opening. The application of estradiol with Rp-cAMPS, an inhibitor of cyclic AMP-dependent protein kinase (protein kinase A), also inhibited the increase in channel opening. The addition of a catalytic unit of protein kinase A to the inside of the excised membrane patch increased the frequency of opening of the BK channels. These results suggest that estradiol interacts with β-adrenergic receptor on the basolateral membrane and regulates the opening of BK channels by protein phosphorylation via a cyclic AMP pathway, without a change in the Ca^<2+> level.
- 東海大学の論文
著者
-
SUZUKI Kazuo
Department of Immunology, Inflammatory Program, Chiba University School of Medicine
-
ODA Yuichi
Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, G
-
Oda Kentaro
Department Of Bio-medical Engineering School Of High-technology For Human Welfare Tokai University
-
Oda Yuichi
Department Of Bio-medical Engineering School Of High-technology For Human Welfare Tokai University
-
Suzuki Kazuo
Department Of Hamamatsu University School Of Medicine
-
TANAKA Sinano
Department of Bio-Medical Engineering, School of High-Technology for Human Welfare, Tokai University
-
SAKAINO Yukimi
Department of Bio-Medical Engineering, School of High-Technology for Human Welfare, Tokai University
-
MATSUDAIRA Takumi
Department of Bio-Medical Engineering, School of High-Technology for Human Welfare, Tokai University
-
Tanaka Sinano
Department Of Bio-medical Engineering School Of High-technology For Human Welfare Tokai University
-
Sakaino Yukimi
Department Of Bio-medical Engineering School Of High-technology For Human Welfare Tokai University
-
Matsudaira Takumi
Department Of Bio-medical Engineering School Of High-technology For Human Welfare Tokai University
-
Suzuki Kazuo
Department Of Bio-medical Engineering School Of High-technology For Human Welfare Tokai University
-
Suzuki Kazuo
Departmens Of Oral Histology Matsumoto Dental College
関連論文
- Cryptococcus neoformans inhibits nitric oxide synthesis caused by CpG-oligodeoxynucleotide-stimulated macrophages in a fashion independent of capsular polysaccharides
- On the Cyto-Toxicity Caused by Quantum Dots
- The Impact of the Chuetsu Earthquake on Asthma Control
- COMPARISON OF MEMBRANE IMMUNOFLUORESCENCE AND CYTOTOXICITY TESTS FOR DETECTION OF CELL SURFACE ANTIGENS OF MAREK'S DISEASE LYMPHOMA-DERIVED CELL LINE
- Involvement of Platelet Activating Factor, Histamine and Serotonin in Acute Lethal Shock Induced by Candida albicans Water-Soluble Extracellular Polysaccharide Fraction (CAWS) in Mice(Miscellaneous)
- Beta-Mannosyl Linkages Negatively Regulate Anaphylaxis and Vasculitis in Mice, Induced by CAWS, Fungal PAMPs Composed of Mannoprotein-Beta-Glucan Complex Secreted by Candida albicans(Highlighted paper selected by Editor-in-chief,Microbiology)
- Laparoscopic Nephrectomy, Ex Vivo Repair, and Autotransplantation for a Renal Artery Aneurysm : Report of a Case
- 1P-206 モルモット盲腸筋層間神経叢培養グリア細胞の受容体、イオンチャネル及び膜電位に対する神経伝達物質の作用(神経・感覚(細胞・膜蛋白質・分子),第47回日本生物物理学会年会)
- Hydrodynamic optimization of a catamaran hull with large bow and stern bulbs installed on the center plane of the catamaran
- Hydrodynamic optimization of ship hull forms in shallow water
- Immunohistochemical Study on DNA Polymerase-α in Human Transplanted Kidneys
- Autoradiographic Studies on Mice Sperm after Bilateral Vasectomy
- Histochemical Study on 3β-Hydroxysteroid Dehydeogenase in Adrenocoltical Adenoma
- Histochemical Study of Alkaline Phosphatase in Human Transplanted Kidneys
- Histochemical Studies of Alkaline Phosphatase in Rat Renal Tumors by Induced Dimethylnitrosamine
- Autoradiographic Study of Rat Seminal Vesicles
- Histochemical Study of Alkaline Phosphatase in Adrenocortical Adenoma
- Effect of Aging on Rat Seminal Vesicles : Histochemical Study
- Histochemical Study of Rat Seminal Vesicle : Effect of Bilateral Vasectomy in Normal Rats and Androgen in Bilaterally Orchiectomized Rats
- Guidelines for urological laparoscopic surgery
- Trafficking of QD-Conjugated MPO-ANCA in Murine Systemic Vasculitis and Glomerulonephritis Model Mice
- Use of a chronological lead-labeling technique for the quantitative study of bone formation in the alveolar wall of the rat molar
- Surgical outcome of laparoscopic radical prostatectomy : summary of early multiinstitutional experience in Japan
- Cryoprotective Activities of Group 3 Late Embryogenesis Abundant Proteins from Chlorella vulgaris C-27
- Levels of Calcium in the Skin of Some Amphibians and Possible Evolutionary Implications
- Calcium Deposits in the Skin of the Toad, Bufo bufo japonicus(Endocrinology)
- Meta-analysis on the Therapeutic State of Hypertensive Population in Japan : Focusing on the Impact of New Diagnostic Criteria of Japanese Guideline for the Management of Hypertension 2000
- Retrospective comparative study of 59 cases of laparoscopic radical prostatectomy : Transperitoneal anterior versus transperitoneal posterior approach
- BK virus subtype IV nephropathy occurring 5 years after kidney transplantation
- Effects of Calcineurin Inhibitors on Pharmacokinetics of Mycophenolic Acid and Its Glucuronide Metabolite during the Maintenance Period Following Renal Transplantation(Pharmacology)
- BK virus subtype 1 infection associated with tubulointerstitial nephritis in a renal allograft recipient
- Histologically benign but telomerase positive adrenal pheochromocytoma
- Simultaneous bilateral laparoscopic adrenalectomy in ACTH-independent macronodular adrenal hyperplasia
- Voiding dysfunction in a patient with adolescent adrenoleukodystrophy
- Intracystic Hemorrhage of Pancreatic Serous Cystadenoma After Renal Transplantation: Report of a Case
- Complicating risk factors for pyelonephritis after extracorporeal shock wave lithotripsy
- Laparoscopy-Assisted Radical Nephrectomy for Renal Cell Carcinoma in Patients on Long-term Hemodialysis: Report of 2 Patients
- Laparoscopic Nephrectomy in Children: Two Case Reports
- Combined Treatment of Staghorn Calculi by Fiberoptic Transurethral Nephrolithotripsy and Extracorporeal Shock Wave Lithotripsy
- Prognostic Factors after Curative Surgery for Renal Cell Carcinoma : Multivariate Analysis of 260 Patients
- Adrenocortical Adenoma Producing 18-Hydroxycorticosterone
- Transrectal Ultrasonography to Predict the Clinical Outcome of Transurethral Microwave Thermotherapy in Patients with Benign Prostatic Hyperplasia
- PSA Value Adjusted for the Transition Zone Volume in the Diagnosis of Prostate Cancer
- Transition Zone Ratio and Prostate-Specific Antigen Density: The Index of Response of Benign Prostatic Hypertrophy to an Alpha Blocker
- Susceptibility Loci to Coronary Arteritis in Animal Model of Kawasaki Disease Induced with Candida albicans-Derived Substances
- Stroke Subtypes and Lesion Sites in Akita, Japan
- Resistance index in benign prostatic hyperplasia using power doppler imaging and clinical outcomes after transurethral vaporization of the prostate
- Role of Doppler ultrasound and resistive index in benign prostatic hypertrophy
- Significant Prognostic Factors for 5-Year Survival after Curative Resection of Renal Cell Carcinoma
- Close Correlation of Tumor Size and Volume with TNM Stage in Renal Cell Carcinoma
- Prognostic Factors for Renal Cell Carcinoma: A Multivariate Analysis of 320 Cases
- Can Symptoms Predict the Prognosis of Renal Cell Carcinoma? A Multivariate Analysis of 320 Patients
- Evaluation of asialoglycoprotein receptor imaging agent as a marker of hepatic ischemia-reperfusion injury and recovery
- Use of fluorescent quantum dot bioconjugates for cellular imaging of immune cells, cell organelle labeling, and nanomedicine : surface modification regulates biological function, including cytotoxicity
- Diffusion-Weighted MRI in Evaluation of Transient Ischemic Attack
- Isotope Scrambling Mechanisms of Chlorine LIS by an Ar Ion Laser Induced Reaction of Cl_2 with C_2Cl_4
- Isotope Shift and Absorption Spectrum of Chlorine Available for Laser Isotope Separation
- Study of Absorption Spectrum of Bromine Molecule for Laser Isotope Separation
- Identification of Cytoplasmic and Nuclear Low-Molecular-Weight Heat-Shock Proteins in Tomato Fruit
- Acute Effect of a Selective Endothelin-A Receptor Antagonist, S-O139, against Cyclosporine-Induced Reduction in Renal Cortical Blood Flow
- Retroperitoneoscopic treatment of a retrocaval ureter
- ABNORMAL CHANGE OF HEART RATE AFTER EXERCISE IN YOUNG ATHLETES HAVING CHEST DISCOMRORT DURING OR AFTER HARD TRAINING : Exercise Test, Rehabilitation : 53 Annual Scientific Meeting, Japanese Circulation Society
- The trend of imported mycoses in Japan
- EFFECT OF IMMUNOSUPPRESSION ON THE URINARY EXCRETION OF BK AND JC POLYOMAVIRUSES IN RENAL ALLOGRAFT RECIPIENTS
- Microlith Formation In Vitro by Madin Darby Canine Kidney (MDCK) Cells
- Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction : an animal model of Kawasaki disease
- Myeloperoxidase Fragments Reacting with Serum from a Patient with Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Positive Glomerulonephritis
- Self-rated Health as a Predictor of Active Life in the Community Elderly
- Clinicoepidemiological manifestations of RPGN and ANCA-associated vasculitides : an 11-year retrospective hospital-based study in Japan
- Quantum Dots Targeted to the Assigned Organelle in Living Cells
- Role of F4/80^+Mac-1^ adherent non-parenchymal liver cells in concanavalin A-induced hepatic injury in mice
- Triggering Characteristics of TEA CO_2 Laser
- Non-genomic action of 17 β-estradiol on opening of Ca^ - and voltage-activated K^+ channel in lacrimal acinar cells
- Sensitization of Ca^ -dependent K^+ -channels in Guinea-pig Pancreatic Acinar Cells by Phosphorylation
- W3:Introduction(Workshop 3 「Laparoscopic Radical Prostatectomy-Outcome of Each Approach」)
- Suppressive effects of low-power laser irradiation on bradykinin-induced action potentials in cultured mouse dorsal root ganglion neurons
- BK virus nephropathy : Clinical experience in a university hospital in Japan
- SUBCELLULAR LOCALIZATION OF DIPEPTIDYL PEPTIDASE IV IN RAT KIDNEY AND SMALL INTESTINE
- IMMUNOHISTOCHEMICAL LOCALIZATION OF DIPEPTIDYL PEPTIDASE IV IN RAT DIGESTIVE ORGANS
- IMMUNOHISTOCHEMICAL LOCALIZATION OF DIPEPTIDYL AMINOPEPTIDASE (DAP) IV IN THE RAT ENDOCRINE ORGANS
- Expression pattern of a newly recognized protein, LECT2, in hepatocellular carcinoma and its premalignant lesion
- Systemic expression of a newly recognized protein, LECT2, in the human body
- Spreading of Nuclear Degradation in Pinus thunbergii Parl. Cuttings under Water Stress : ENVIRONMENTAL AND STRESS RESPONSES
- A patient with a preoperative hemoglobin concentration of 1.8 g・dl^1 : How was the life-threatening anemia tolerated without any intensive care?
- Evolution of pollinator generalization in bumblebee-pollinated plants
- The Efficacy of Laparoscopy-Assisted Surgery for Renal Tumors
- MPO-ANCA Binding Site on MPO Molecule Estimated from Epitope Mapping Study and Molecular Modeling
- LECT2 intron/exson structure : potential strategies for bio-imaging
- Prevalence of Inherited Myeloperoxidase Deficiency in Japan
- Chromosome Numbers of Isodon (Lamiaceae) in Japan
- A Reciprocal Regulation of Ca^-Activated K^+ Channel by Insulin and Somatostatin in Guinea-Pig Pancreatic Acinar Cells
- A High Current Gain Si Metal Insulator Semiconductor Tunnel Emitter Transistor
- CHANGES IN FUNCTIONAL CERULOPLASMIN CONCENTRATIONS OF PLASMA AND EXUDATE AND THE EFFECT OF EXOGENOUS CERULOPLASMIN ON THE CARRAGEENIN-INDUCED INFLAMMATION IN RATS
- 12. Strength of a Car Carrier Deformed by Racking Loads
- Clinical factors associated with severity in hospitalized children infected with avian influenza (H5N1)
- Metabolomics of Selenium : Se Metabolites Based on Speciation Studies
- Gasless Laparoscopy-Assisted Live Donor Nephrectomy(2)(Endoscopic Live Donor Nephrectomy)
- W3-3 Laparoscopic Radical Prostatectomy-Transperitoneal Anterior Approach(Workshop 3 「Laparoscopic Radical Prostatectomy-Outcome of Each Approach」)
- Movements of the Plasma Membrane Proteins during Exocytotic Secretion
- Comparison of Activation of Non-selective Cation Channels by Protein Kinase-A in Guinea-pig and Mouse Pancreatic Acinar Cells