Effects of Dietary Pyrazinamide on the Metabolism of Tryptophan to Niacin in Streptozotocin-diabetic Rats
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概要
- 論文の詳細を見る
We investigated the effects of feeding with a diet containing pyrazinamide (PYR) on the metabolism of L-tryptophan (Trp) to nicotinamide in streptozotocin (STZ)-diabetic rats and whether the diabetic action of STZ is prevented by feeding with the PYR diet, which is known as an inhibitor of aminocarboxymuconate-semialdehyde decarboxylase and poly(ADP)ribose synthetase and therefore, signiticantly increases the formation of nicotinamide from Trp in normal rats. As was expected, feeding with the PYR diet to the STZ-injected rats caused a signiticantly increased excretion of nicotinamide and its metabolites like that in normal rats. The body weight increased in the STZ-injected rats fed with the PYR diet, while it was lost in the STZ-injected rats fed with the non-PYR diet. However, the blood glucose level and the urinary excretion of glucose were not improved even when the rats were fed with the PYR diet. Therefore, it was suggested that chronically increasing the formation of nicotinamide from Trp could not completely prevent the STZ-diabetic action.
- 社団法人日本農芸化学会の論文
- 1997-10-23
著者
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SHIBATA Katsumi
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
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Shibata Katsumi
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Kondo Takako
Department of Human Health Science, Faculty of Human Sciences, Osaka International University for Wo
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Kondo Takako
Department Of Anatomy School Of Medicine Fujita-gakuen Health University
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Ishikawa Aya
Department Of Human Health Science Faculty Of Human Sciences Osaka International University For Wome
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Kondo Takako
Department Of Human Health Science Faculty Of Human Sciences Osaka International University For Wome
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Shibata Katsumi
Department Of Human Health Science Faculty Of Human Sciences Osaka International University For Wome
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