Conversion Ratio of Tryptophan to Niacin in Rats Fed a Vitamin B1-Free Diet
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概要
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The effect of a vitamin B1-free diet on the conversion ratio of tryptophan to niacin in rats was investigated using the current methods for determination of the intermediate metabolites. Rats were fed with diets with or without B1 for 33 days. The body weight gain and food intake in the B1-free group were almost the same as the control group for 10 days, but, they steeply dropped after that time and the conversion ratio of tryptophan to niacin began to increase. The ratio reached 7-fold that of the control group on the last day of the experiment. This finding seriously differed from the previous reports, which described that B 1 was needed in the first part of tryptophan conversion to niacin and that the conversion ratio of tryptophan to niacin decreased in B1-deficient rats. Furthermore, the activity of tryptophan oxygenase, in which it was reported that B 1 is required for the tryptophan catalytic reaction, did not decrease but increased even when the B1-free diet was fed. These results suggest that there is a very small possibility of the direct involvement of B 1 in the conversion of tryptophan to niacin.
著者
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Shibata Katsumi
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Kondo Takako
Department Of Anatomy School Of Medicine Fujita-gakuen Health University
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Yonezima Michiko
Department Of Human Health Science Faculty Of Human Sciences Osaka International University For Wome
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SHIBATA Katsumi
Department of Human Health Science, Faculty of Human Sciences, Osaka International University for Women, Moriguchi
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KONDO Takako
Department of Human Health Science, Faculty of Human Sciences, Osaka International University for Women, Moriguchi
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YONEZIMA Michiko
Department of Human Health Science, Faculty of Human Sciences, Osaka International University for Women, Moriguchi
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