Fate of Nicotinamide Differs Due to an Intake of Nicotinamide
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概要
- 論文の詳細を見る
We found that the catabolism of nicotinamide (Nam) differs due to an intake of Nam itself in rats. When rats were fed with a Nam-free, tryptophan-limiting diet, the major catabolite of niacin was N^1-methyl-4-pyridone-3-carboxamide (4-Py). However, its percentage was changed with increasing the intake of Nam. The major metabolite was N^1-methylnicotinamide (MNA) in the diet containing 0.006% Nam, or 0.1% Nam. The toxicity of excess Nam was observed when rats were fed with a 0.5% Nam-containing diet. In this diet, the major metabolite was Nam N-oxide and it was noted that the urinary excretion of nicotinic acid and its metabolite nicotinuric acid was observed. Therefore, these acids might be detected only when the toxicity of Nam appears.
- 社団法人日本農芸化学会の論文
- 1996-07-23
著者
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Shibata Katsumi
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Taguchi Hiroshi
Laboratory Of Biological Chemistry Faculty Of Bioresources Mie University
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Shimada Hisako
Department Of Human Health Science Faculty Of Human Sciences Osaka International University For Wome
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Shibata Katsumi
Department Of Human Health Science Faculty Of Human Sciences Osaka International University For Wome
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