Inhibition of N^1-Methylnicotinamide Oxidase Activity by a Large Amount of N^1-Methylnicotinamide Injected into Rats(Food & Nutrition)

概要

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The effects of the injection of a large amount of N^1-methylnicotinamide (MNA) (500mg per kg body weight) on the ratio of N^1-methyl-4-pyridone-3-carboxamide (4-py) to N^1-methyl-2-pyridone-5-carboxamide (2-py) excretion, and the activities of 2-py and 4-py forming MNA oxidases were investigated in rats. The injected MNA was excreted very rapidly into the urine ; 46% of the dose was excreted from 0〜3hr post-injection, 15% from 3〜6hr, 6% from 6〜9hr and 1.5% from 9〜12hr. The ratio of 4-py to 2-py also decreased rapidly ; the ratio being about 0.6, 0.4, 0.4 and 0.6 from 0〜3hr, 3〜6hr, 6〜9hr and 9〜12hr post-injection, respectively. This ratio then recovered rapidly ; being about 2, 5.5, 8.5 and 9.7 from 12〜24hr, 24〜48hr, 48〜72hr and 72〜96hr post-injection, respectively. The normal range of 4-py to 2-py excretion ratio is 8〜14. So, this ratio returned to a normal level by day 3 post-injection. The rats were killed 5 hr after the MNA injection. At this time (the lowest ratio was observed around this time), the activities of 2-py and 4-py forming MNA oxidases in the injected group were 59% and 11% of the normal levels, respectively. Therefore, it was found that the decreased ratio of 4-py to 2-py excretion with the MNA injection was mainly due to the higher inhibition of the 4-py forming MNA oxidase than of the 2-py forming MNA oxidase by the MNA injection.
社団法人日本農芸化学会の論文
1989-09-23