Effect of Adding Methionine and Threonine to a Protein-free Diet on the Metabolism of Nicotinamide

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We have been attempting to confirm the hypothesis that the excretion ratio of nicotinamide metabolites, [N^1-methyl-2-pyridone-5-carboxamide (2-Py) + N^1-methyl-4-pyridone-3-carboxamide (4-Py)]/N^1-methyl-nicotinamide (MNA), reflects the adequacy of amino acid nutrition, but not of niacin nutrition. It is known that methionine and threonine supplementation to a protein-free diet reduced body weight loss. In this paper, we investigated whether rats fed with a protein free-diet supplemented with methionine and threonine would result in this excretion ratio being increased or not. The body weight loss was markedly reduced by the supplementation with both amino acids, as has been reported, and under the conditions, the excretion ratio significantly increased. The activity of 4-Py-forming MNA oxidase, which controls the change in excretion ratio, also increased significantly. From the present results and our previous results, it was proved that the excretion ratio of nicotinamide metabolites, (2-Py + 4-Py)/MNA, reflects the adequacy of amino acid nutrition, but not of niacin
社団法人日本農芸化学会の論文
1993-09-23