In Vivo Inhibition of Kynurenine Aminotransferase Activity by Isonicotinic Acid Hydrazide in Rats
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概要
- 論文の詳細を見る
It is known that the anti-tuberculosis drug, isonicotinic acid hydrazide (INH), causes pellagra, a niacin deficiency syndrome, and peripheral neuritis in humans. We investigated the effects of INH on the metabolism of tryptophan to niacin in rats fed on a niacin-free diet. The activity of kynurenine aminotransferase was significantly inhibited by feeding a diet containing INH and by an injection of INH, and the urinary excretion of xanthurenic acid, the side-reaction product of the conversion pathway of tryptophan to niacin, was below the limit of detection. The inhibition of kynurenine aminotransferase and the resulting decreased formation of xanthurenic acid generally mean a higher conversion ratio of tryptophan to niacin. However, the conversion ratio was no different between the control and INH groups.
- 社団法人日本農芸化学会の論文
- 1996-05-23
著者
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SHIBATA Katsumi
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefectu
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Shibata K
Department Of Human Health Science Faculty Of Human Sciences Osaka International University For Wome
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Shibata K
Course Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures The U
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Shibata Katsumi
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Kondo Takako
Department of Human Health Science, Faculty of Human Sciences, Osaka International University for Wo
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Shibata Kenichi
Laboratory Of Nutrition Chemistry Department Of Food Science And Technology
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Shibata K
Laboratory Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures T
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Saito Kaori
Technology R&d Headquarters Materials And Devices Development Center Bu Sanyo Electric Co.
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Kondo T
Tokyo Univ. Agriculture And Technol. Tokyo Jpn
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Kondo Takako
Department Of Anatomy School Of Medicine Fujita-gakuen Health University
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MARUGAMI Miyuki
Department of Human Health Science, Faculty of Human Sciences, Osaka International University for Wo
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Marugami Miyuki
Department Of Human Health Science Faculty Of Human Science Osaka International University For Women
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