Change of Tryptophan-Niacin Metabolism in D-Galactosamine-Induced Liver Injury in Rat
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概要
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The change of tryptophan-niacin metabolism in D-galactos-amine (D-galN) injected rats was investigated. Rats fed with niacin-free diets containing 40% casein for 11 days were injected with D-galN (0.8 g/kg body weight). The urinary excretions of nicotinamide and its metabolites, and the activity of liver α-amino-β-carboxymuconate-E-semialdehyde decarboxylase (ACMSD) (EC 4.1.1.45), a key enzyme of tryptophan-niacin metabolism, were assayed. As the result, the urinary excretions of N1-methylnicotinamide (MNA), N1-methyl-2-pyridone-5-carboxamide (2-Py), N1-methyl-4-pyridone-3-carboxamide (4-Py) and their sum (nicotinamide+MNA+2-Py+4-Py) were higher in the D-galN-injected group than in the control group. Hepatic ACMSD activity in the D-galN-injected group was lower than that of the control group. These results suggest that the increase in urinary excretion of nicotin-amide and its metabolites after the injection of D-galN is considered to be attributable to a decrease in liver ACMSD activity.
- 財団法人 学会誌刊行センターの論文
著者
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Shibata Katsumi
Department Of Food Science And Nutrition School Of Human Cultures The University Of Shiga Prefecture
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Sanada Hiroo
Department Of Agricultural Chemistry Faculty Of Horticulature Chiba University
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OHTA Takeo
Department of Bioproduction Science, Faculty of Horticulture, Chiba University
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EGASHIRA Yukari
Department of Bioproduction Science, Faculty of Horticulture, Chiba University
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Komine Tomoko
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Egashira Y
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Egashira Yukari
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Sanada Hiroo
Department of Bioproduction Science, Faculty of Horticulture, Chiba University
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OHTA Takeo
Department of Bioproduction Science, Faculty of Horticulture
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SHIBATA Katsumi
Department of Human Health Science, Faculty of Human Sciences Osaka International Univeristy for Women
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OHTA Takeo
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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