Effects of Various Kinds of Dietary Amino Acids on the Hepatotoxic Action of D-Galactosamine in Rats
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概要
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The protective effects of various kinds of dietary amino acids against the hepatotoxic action of D-galactosamine (GalN) were examined. Male Wistar rats fed with 20% casein diets containing 10% or 5% amino acid for one week were injected with GalN (800 mg/kg body weight), and the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) activities, the hepatic glycogen concentration, and the serum glucose-level were examined 20 hours after the injection. In the groups with the 10% amino acid diets, activities of AST, ALT, and LDH in serum of 10% L-glutamine (Gln), 10% L-asparagine (Asn), and 10% L-serine (Ser) groups were significantly lower than those of the control group, and in the groups with the 5% amino acid diets, those activities of 5% L-histidine (His), 5% L-tyrosine (Tyr), 5% L-lysine (Lys), and 5% L-glycine (Gly) groups were also lower than those of the control group. The concentration of liver glycogen of 10% Gln-, 10% Asn-, and 10% Sergroups and those levels of 5% His-, 5% Tyr-, 5% Lys-, and 5% Gly-groups were also significantly higher than that of the control group. As a result, it was found that some kinds of dietary amino acid such as L-Ser, L-Asn, L-His, L-Lys, L-Tyr, and L-Gly, in addition to L-Gln were effective to protect the rats from GalN-induced injury.
- 社団法人日本農芸化学会の論文
- 1999-02-23
著者
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Ohta T
Hokkaido Food Processing Res. Center Hokkaido Jpn
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SANADA Hiroo
Graduate School of Science and Technology, University of Chiba
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Sanada H
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Ohta T
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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EGASHIRA Yukari
Department of Bioproduction Science, Faculty of Horticulture, Chiba University
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WANG Binbin
Graduate School of Science and Technology, Chiba University
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ISHIHARA Moyuru
Graduate School of Science and Technology, Chiba University
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EGASHIRA Yukari
Graduate School of Science and Technology, Chiba University
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OHTA Takeo
Graduate School of Science and Technology, Chiba University
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Wang Binbin
Graduate School Of Science And Technology Chiba University
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Egashira Y
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Ishihara M
Ryukyu Univ. Okinawa Jpn
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Ishihara Moyuru
Graduate School Of Science And Technology Chiba University
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Sanada Hiroo
Graduate School Of Sci. And Technol. Chiba Univ.
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Egashira Yukari
Graduate School Of Sci. And Technol. Chiba Univ.
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