Effect of Indigestible Oligosaccharides on the Hepatotoxic Action of D-Galactosamine in Rats
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概要
- 論文の詳細を見る
The effects of dietary oligosaccharides on the hepatotoxic action of D-galactosamine (GalN) were investigated in this study. Male Wistar rats fed with 20% casein diets containing 10% oligosaccharide or D-galactose (Gal) for 2 weeks were injected with GalN (1,900 mg/kg of body weight), and the plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and the hepatic glycogen concentration were examined 20 hours after the injection. The plasma AST and ALT activities in experiment 1 for the Gal+neomycin (NEO) group were significantly lower than those for the control (C), NEO, raffinose (RAF)+NEO and galacto-oligosaccharide (GALO)+NEO groups. In experiment 2,these activities were significantly lower in the Gal, Gal+NEO and RAF groups than in the RAF+NEO group when the groups were treated with GalN. On the other hand, in respect of the hepatic glycogen concentration in experiment 1,that of the Gal+NEO group was higher than that of the C, NEO, RAF+NEO or GALO+NEO groups. In experiment 2,this parameter was significantly higher in the Gal, Gal+NEO and RAF groups than in the RAF+NEO group after the GalN treatment. As a result, it is suggested that the GalN-hepatitis-suppressive effects of indigestible oligosaccharides such as RAF or GALO is mediated by the action of intestinal bacteria.
- 社団法人日本農芸化学会の論文
- 1998-08-23
著者
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Ohta T
Hokkaido Food Processing Res. Center Hokkaido Jpn
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SANADA Hiroo
Graduate School of Science and Technology, University of Chiba
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Sanada H
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Ohta T
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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EGASHIRA Yukari
Department of Bioproduction Science, Faculty of Horticulture, Chiba University
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WANG Binbin
Graduate School of Science and Technology, Chiba University
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EGASHIRA Yukari
Graduate School of Science and Technology, Chiba University
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OHTA Takeo
Graduate School of Science and Technology, Chiba University
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Wang Binbin
Graduate School Of Science And Technology Chiba University
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Egashira Y
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Sanada Hiroo
Graduate School Of Sci. And Technol. Chiba Univ.
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Egashira Yukari
Graduate School Of Sci. And Technol. Chiba Univ.
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