Effects of Various Kinds of Edible Seaweeds in Diets on the Development of D-Galactosamine-Induced Hepatopathy in Rats
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概要
- 論文の詳細を見る
In the present study we investigated the effects of 11 kinds of edible seaweeds (6 brown and 5 red algae) which contain characteristic seaweed dietary fibers on the induction of D-GalN (D-galactosamine)-hepatopathy in rats (Exps. 1 and 2). Then, the efficacy of various components prepared from Gelidium sp., which was found to alleviate the hepatopathy in Exps. 1 and 2, was examined (Exp. 3). The rats were fed the diets containing various kinds of seaweeds (Exps. 1 and 2), or several components of Gelidium sp. such as total dietary fiber (TDF), soluble dietary fiber (SDF), insoluble dietary fiber (IDF) and dietary fiber-free components (DFFC) (Exp. 3), for 8 d. The rats in all experiments were injected with D-GalN (800 mg/kg body weight) intraperitoneally at the 7th day to induce liver injury and were sacrificed 24 h after the injection of D-GalN. The serum transaminase activities (ALT and AST) and lactate dehydrogenase (LDH) were determined to evaluate the levels of hepatopathy. In Exp. 3, the total GSH concentration in the liver, plasma and cecal contents and organic acid concentration in cecal contents were also evaluated. In Exps. 1 and 2, repressive effects against D-GalN-hepatopathy were shown by four seaweeds Laminaria sp., Gelidium sp., Sargassum fulvellum and Eisenia bicyclis. In Exp. 3, it was found that protective activity in Gelidium sp. against D-GalN-hepatopathy existed not only in the SDF but also in the DFFC fraction. The results in Exp. 3 also indicated that the total GSH but not organic acid concentration in the cecal contents were significantly correlated with serum AST activity, suggesting that the protective effect of Gelidium sp. on D-GalN-hepatopathy in rats is related to GSH metabolism in the intestine.
- 日本ビタミン学会の論文
著者
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Sanada Hiroo
Laboratory of Foods and Nutritional Chemistry, Department of Agricultural Chemistry, Faculty of Hort
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Sanada Hiroo
Laboratory Of Food And Nutrition Graduate School Of Science And Technology Chiba University
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Kawano Naoko
Laboratory Of Food And Nutrition Graduate School Of Science And Technology Chiba University:departme
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Egashira Yukari
Laboratory Of Food And Nutrition Graduate School Of Science And Technology Chiba University
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Sanada Hiroo
Graduate School Of Sci. And Technol. Chiba Univ.
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Egashira Yukari
Graduate School Of Sci. And Technol. Chiba Univ.
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Sanada Hiroo
Laboratory Of Food And Nutrition Graduate School Of Horticulture Chiba University
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Egashira Yukari
Laboratory Of Food And Nutrition Graduate School Of Horticulture Chiba University
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