Ginkgo biloba Extract markedly Induces Pentoxyresorufin O-Dealkylase Activity in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We examined the effect of Ginkgo biloba extract (GBE) on hepatic drug-metabolizing enzymes, particularly cytochrome P450 (CYP), in rats. Rats were fed a GBE-containing diet or received GBE by intragastric gavage. The concentration of CYP and activity of various CYP enzymes in the liver were increased in a dose- and time-dependent manner. Significant increases in the concentration and activities of CYP enzymes were detected on day 1 of feeding of a 0.5% GBE diet and after administration of 10 mg GBE/kg body weight for 5 days by intragastric gavage. Among the CYP enzymes, the activity of pentoxyresorufin O-dealkylase (PROD), a CYP2B enzyme, was especially markedly increased. The induction of CYP2B enzyme by GBE was confirmed by Western blot analysis. Addition of GBE to a CYP assay system in vitro caused concentration-dependent inhibition of various CYP enzyme activities. The inhibition was more marked for the microsomal enzymes from GBE-treated rats than for those from control rats and more marked against PROD activity among the CYP enzymes tested. When the inhibition of various CYP enzymes activities by GBE in vitro was compared, no marked difference was observed between rat and human hepatic microsomal enzymes. These results indicate that excess intake of GBE induces CYP enzymes, particularly PROD, and may modify the efficacy of drugs taken simultaneously.
- 社団法人 日本薬理学会の論文
- 2002-12-01
著者
-
Umegaki Keizo
The National Institute Of Health And Nutrition
-
Umegaki Keizo
National Institute Of Health And Nutrition
-
Umegaki Keizo
静岡県立大学 生活健康科研究
-
KUBOTA Yoko
Department of Biopharmaceutics, Nihon Pharmaceutical University
-
SHINOZUKA Kazumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
Kubota Y
Department Of Biopharmaceutics Nihon Pharmaceutical University
-
Yamada Kazuhiko
National Cardiovascular Center
-
Yamada Kazuhiko
National Institute Of Health And Nutrition
-
SAITO Keiko
Graduate School of Science and Technology, University of Chiba
-
SANADA Hiroo
Graduate School of Science and Technology, University of Chiba
-
Sanada Hiroo
Graduate School Of Science And Technology University Of Chiba
-
Shinozuka Kazumasa
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Shinozuka Kazumasa
Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Shinozuka Kazumasa
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
-
Shinozuka Kazumasa
Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University
-
Umegaki K
National Institute Of Health And Nutrition
-
Umegaki Keizo
The National Institute Of Health And Nutrition Shinjuku-ku
-
UMEGAKI Keizo
IAA National Institute of Health and Nutrition
-
Shinozuka K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kwon Young
Department Of Biopharmaceutics Nihon Pharmaceutical University
-
Shiono K
Graduate School Of Science And Technology University Of Chiba
-
Umegaki Keizo
National Inst. Of Health And Nutrition
-
Sanada Hiroo
Graduate School Of Sci. And Technol. Chiba Univ.
-
Saito Keiko
Graduate School Of Science And Technology University Of Chiba
-
Saito Keiko
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
-
Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
関連論文
- Effects of Dietary Ingredients on Function and Expression of P-Glycoprotein in Human Intestinal Epithelial Cells
- Characterization of cardiac size and function in SHRSP.Z-Lepr[fa]/IzmDmcr rats, a new animal model of metabolic syndrome
- Finite Element Stress Analysis of Spent Nuclear Fuel Disposal Canister in a Deep Geological Repository
- ON COMPLETELY REGULAR AND QUASI-COMPLETELY REGULAR ORDERED SEMIGROUPS
- Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats(Pharmacology)
- Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
- Safety of Dietary Supplements:Chronotropic and Inotropic Effects on Isolated Rat Atria
- Improvement of Regional Perfusion after Bone Marrow Cell Transplantation : Asessment of Myocardial Perfusion by Contrast Echocardiography and Histology
- Biochemical Evidence of Atherosclerosis Progression Mediated by Increased Oxidative Stress in Apolipoprotein E-Deficient Spontaneously Hyperlipidemic Mice Exposed to Chronic Cigarette Smoke
- Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome
- Long-Term Feeding of Ginkgo biloba Extract Impairs Peripheral Circulation and Hepatic Function in Aged Spontaneously Hypertensive Rats(Pharmacognosy)
- P2Y Receptor-Mediated Ca^ Signaling Increases Human Vascular Endothelial Cell Permeability
- Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function : Purinergic Modulation of Vascular Sympathetic Neurotransmission
- Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries
- Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
- Inhibitory Effect of Cordyceps sinensis on Spontaneous Liver Metastasis of Lewis Lung Carcinoma and B16 Melanoma Cells
- Regional Differences in Noradrenaline-Induced Release of Adenosine Triphosphate from Rat Vascular Endothelium
- High-Spin States in ^Nb(Nuclear physics)
- Characterization of Cardiac Size and Function in SHRSP.Z-Leprfa/IzmDmcr Rats, a New Animal Model of Metabolic Syndrome
- Highly Sensitive Measurement of P-Glycoprotein-Mediated Transport Activity in Caco-2 Cells
- Effect of Vanadate on ATP-Induced Increase in Intracellular Calcium Ion Levels in Human Umbilical Vein Endothelial Cells
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line(Biochemistry)
- A Solid-state ^O NMR Study of β-Glycine : High Sensitivity of ^O NMR Parameters to Hydrogen-bonding Interactions
- Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect
- Antinociceptive Effects of St. John's Wort, Harpagophytum Procumbens Extract and Grape Seed Proanthocyanidins Extract in Mice(Pharmacology)
- EFFECT OF SHAKUYAKU-KANZOH-TOH, A PRESCRIPTION COMPOSED OF SHAKUYAKU (PAEONIAE RADIX) AND KANZOH (GLYCYRRHIZAE RADIX) ON GUINEA PIG ILEUM
- Highly Conserved Antigenic Structure of the Factor VIII C2 Domain in Some Mammals
- Seismic Intensity and Mental Stress after the Great Hanshin-Awaji Earthquake
- Life Events and Posttraumatic Stress in Hanshin-Awaji Earthquake Victims
- Ginkgo biloba Extract markedly Induces Pentoxyresorufin O-Dealkylase Activity in Rats
- Role of Fat Tissue Mass on Metabolism and Excretion of Lipophilic Chemicals (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Damaging Effect of Organochlorine Chemicals to Hepatic DNA of Mice
- Effect of Nutrients on Accumulation of Trichloroethylene in Rats (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- Effect of Nutrients on Metabolism and Accumulation of Chlorobenzenes in Rats (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- Effects of Fat Content in Tissues on Metabolism and Accumulation of Pentachlorobenzene in Rats. (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- Demographic and Socioeconomic Determinants of the Use of Periodic Health Examinations : Public vs. Private Sector
- The Benefits of Supplementary Private Health Insurance for Healthcare Utilization and Survival among Stomach Cancer Patients
- Pharmaceutical and Pharmacological Evaluations of "Indometacin M Ointment" as a Pharmacy Preparation
- Time-Dependent Induction of Hepatic Cytochrome P450 Enzyme Activity and mRNA Expression by Bilobalide in Rats
- Generation of Nitric Oxide from Spin-trapping Agents under Oxidative Conditions
- Protective Effects of Quercetin and Its Metabolites on H_2O_2-Induced Chromosomal Damage to WIL2-NS Cells
- Effects of Various Kinds of Dietary Amino Acids on the Hepatotoxic Action of D-Galactosamine in Rats
- Effect of Indigestible Oligosaccharides on the Hepatotoxic Action of D-Galactosamine in Rats
- Analytical Method of Measuring Tea Catechins in Human Plasma by Solid-Phase Extraction and HPLC with Electrochemical Detection
- Grape Seed Extract Prevents H_2O_2-Induced Chromosomal Damage in Human Lymphoblastoid Cells(Pharmacology)
- Spatiotemporal ESR-CT Study on the Metabolism of Spin-labeled Polysaccharide in a Mouse
- Disturbance of Circadian Rhythm in Heart Rate, Blood Pressure and Locomotive Activity at the Stroke-Onset in Malignant Stroke-Prone Spontaneously Hypertensive Rats
- Phospholipid Metabolism in Platelets from Stroke-Prone Spontaneously Hypertensive Rats and Wistar Kyoto Rats
- Stopped-Flow and Spectrophotometric Study on Radical Scavenging by Tea Catechins and the Model Compounds
- Beta Ray-induced Scission of DNA in Tritiated Water and Protection by a Green Tea Percolate and (-)-Epigallocatechin Gallate
- Effects of Theanine on Alcohol Metabolism and Hepatic Toxicity(Biopharmacy)
- Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline
- POSSIBILITIES FOR ADENOSINE MODULATION OF PERISTALTIC REFLEX IN GUINEA PIG ISOLATED ILEUM
- PHYSIOLOGICAL IMPLICATION OF THE L-ARGININE-NITRIC OXIDE PATHWAY IN CIRCULATION
- Are Low Total Serum Antioxidant Status and Elevated Levels of C-Reactive Protein and Monocyte Chemotactic Protein-1 Associated With Cardiac Syndrome X?
- Participation of Endogenous Noradrenaline in the Relaese of ATP by High Potassium in the Rat Caudal Artery
- Changes in cellular immunity during chemotherapy for testicular cancer
- THE INFLUENCE OF EXTRACELLULAR Ca2+ CONCENTRATION ON THE INHIBITORY EFFECT OF ADENOSINE IN GUINEA-PIG ILEAL LONGITUDINAL MUSCLES
- Taurine Prevents Oxidative Damage of High Glucose-Induced Cataractogenesis in Isolated Rat Lenses
- Effect of Dietary Fiber in Edible Seaweeds on the Development of D-Galactosamine-Induced Hepatopathy in Rats
- Effects of Various Kinds of Edible Seaweeds in Diets on the Development of D-Galactosamine-Induced Hepatopathy in Rats
- Effects of Dietary Corn Bran Hemicellulose and Neomycin on Hepatic Caspase-3 Activity and Glycoprotein Concentration in Rats Treated with or without D-Galactosamine
- A NOTE ON WEAKLY PRIME IDEALS OF ORDERED SEMIGROUPS
- Distribution and Mobilization of Chlorinated Benzenes in Fat Cells from Rats Given Various Chlorinated Benzenes : Comparison between Young and Adult Rats (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Hypocholesterolemic Mechanism of Chlorella : Chlorella and Its Indigestible Fraction Enhance Hepatic Cholesterol Catabolism through Up-Regulation of Cholesterol 7α-Hydroxylase in Rats
- Synthesis of Copper Phthalocyanine-containing Hyperbranched Polymer Starting from 1,2-Bis(3,4-dicyanophenoxy)benzene and CuCl
- Physical Exercise Induces Oxidation of Plasma Protein Thiols to Cysteine Mixed Disulfides in Humans
- Use of Dietary Supplements among Preschool Children in Japan
- Electrical Properties of Self-Assembled Monolayers Using STM
- Theoretical and Experimental Analysis on the Thickness-Controlled Residual Stress during Drying of Solvent-Absorbed Polymer Films
- PHENTOLAMINE TEST FOR OPERATIVE COMPLICATIONS OF PHEOCHROMOCYTOMA : ITS PROGNOSTIC IMPORTANCE
- Differences in the Influence of AIN-Purified and Non-purified Diets on the Development of Hypertension in SHR and DOCA-salt Hypertensive Rats
- A Structural Analysis of a Mechanical Heart Valve Prosthesis with Flat Leaflet
- Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome
- Noninvasive Functional Imaging of the Retina Reveals Outer Retinal and Hemodynamic Intrinsic Optical Signal Origins
- Rapid Increase in the National Treatment Costs for Hepatitis A Infections in Korea
- Effects of Functional Food Constituents on P-glycoprotein Activity in Caco-2 Cells Determined by a New Method Using Confocal Laser Scanning Microscopy
- Effects of Short-Term Consumption of a Large Amount of Tea Catechins on Chromosomal Damage, Oxidative Stress Markers, Serum Lipid, Folic Acid, and Total Homocysteine Levels : A Randomized, Double-Blind, Controlled Study
- Effects of Short-term Ginkgo Biloba Extract Feeding on Hypotensive Action of Nicardipine in Rats
- The color stability of silorane- and methacrylate-based resin composites
- Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line
- Electrical Transport Properties of Au-Doped Deoxyribonucleic Acid Molecules
- Determining the Self-Assembling and Redox Process of a Viologen Monolayer by Electrochemical Quartz Crystal Microbalance
- Design and Optical Characterization of Passive Pixel with Sensitivity-Improved InGaAs/InP Phototransistors Considering Light-Dependent Shunt Resistance for Near Infrared Imaging Applications
- Aluminum Packaging for Light-Emitting Diode using Selectively Anodizing Method
- Possible Participation of ATP in Changes of Blood Pressure in SHR and Old Rats
- Arachidonic acid (AA) metabolism in platelets from SHRSP and WKY
- Hypertensive Effects of Nitroarginine:Comparison between WKY and SHRSP
- P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability
- Effects of Restricted Feeding on the Absorption, Metabolism, and Accumulation of Pentachlorobenzene in Rats.
- Improved Method for the Analysis of Ascorbic Acid in Plasma by High-Performance Liquid Chromatography with Electrochemical Detection.
- Feeding of Palm Oil Carotene to Mice Did not Modify X-Ray-Induced Chromosomal Damage in Bone Marrow Cells.
- Effects of adenosine on contractile response of circular muscle in electrically stimulated guinea-pig ileum.
- Enthalpies of Hydrogen Bond Formation between Diphenylamines and Dimethyl Sulfoxide
- Determination of the Effects of Green Tea Extract and Fruit Extracts on P-glycoprotein Activity in Caco-2 Cells by Using a New Method Involving Confocal Laser Scanning Microscopy