Time-Dependent Induction of Hepatic Cytochrome P450 Enzyme Activity and mRNA Expression by Bilobalide in Rats

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概要

• 論文の詳細を見る

• A single dose by gavage of bilobalide (30 mg/kg) was found to produce a time-dependent induction of hepatic cytochrome P450 (CYP) enzyme activity and protein expression in rats. An RT-PCR study further showed that mRNA expression of CYP2B was maximal at 6 h. Plasma and liver bilobalide concentration in rats following administration of Ginkgo biloba extract equivalent to bilobalide of approximately 40 mg/kg showed a similar response to that exhibited by mRNA expression. These findings suggest that bilobalide markedly induced hepatic CYPs, but the induction could be mitigated due to rapid elimination from the liver.

• 社団法人 日本薬理学会の論文
• 2009-03-20

著者

• Umegaki Keizo

  National Institute Of Health And Nutrition

• YAMADA Shizuo

  Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, S

• Yamada Shizuo

  Dep. Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) Program School O

• YAMAZAKI YUKO

  Department of Experimental Radiology and Health Physics, Fukui Medical University, School of Medicin

• Yamada Shizuo

  Department Of Pharmacokinetics And Pharmacodynamics And Global Coe Program School Of Pharmaceutical

• Yamada Shizuo

  Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka

• TAKI Yuko

  National Institute of Health and Nutrition

• SHIMURA Fumio

  Department of Food & Nutrition, Jumonji University

• Shimura Fumio

  Department Of Food & Nutrition Jumonji University

• Yamazaki Yuko

  Department Of Experimental Radiology And Health Physics Fukui Medical University School Of Medicine

• Umegaki Keizo

  National Inst. Of Health And Nutrition

• Yamazaki Yuko

  Department Of Chemistry Tokyo Gakugei University

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