EFFECTS OF NICOTINIC RECEPTOR AGONISTS AND ANTAGONISTS ON UPTAKE AND EFFLUX OF <SUP>45</SUP>Ca IN PERFUSED BOVINE ADRENAL GLANDS
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概要
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The actions of nicotinic receptor agonists and antagonists on Ca movement in perfused bovine adrenal glands were investigated. 1, 1 -dimethyl-4-phenylpiperazinium (DMPP, 0.3 mM) and acetylcholine (ACh, 0.3 mM, containing 10 μM physostigmine) produced a significant increase in <SUP>45</SUP>Ca efflux from <SUP>45</SUP>Ca preloaded adrenal glands and which was closely correlated with an increase of adrenal catecholamine (CA) secretion. In the perfused adrenal glands which the stimulation of <SUP>45</SUP>Ca efflux as well as adrenal CA secretion by ACh was abolished in Ca free Lockes solution, the application of Ca (22 mM) considerably restored the stimulatory response of <SUP>45</SUP>Ca efflux to ACh. There was a significant increase in the <SUP>45</SUP>Ca uptake by nicotinic agonists-stimulated adrenal glands, which was responsible for the enhancement of Ca uptake by adrenal medulla and not by the cortex. The maximal increase in <SUP>45</SUP>Ca uptake by nicotinic agonists preceded that in the adrenal CA secretion. Nicotinic antagonists such as surugatoxin (SGTX, 20 μM) and mecamylamine (0.1 mM) markedly (60-90%) reduced the stimulation of uptake and efflux of <SUP>45</SUP>Ca by the agonists. Thus the present study has demonstrated that nicotinic agonists-induced CA secretion may be associated with a stimulation of uptake and efflux of Ca in bovine adrenal medulla and that nicotinic antagonists may inhibit the stimulated flux of Ca by the action on nicotinic receptors of adrenal chromaffin cells.
- 社団法人 日本薬理学会の論文
著者
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Yamada Shizuo
Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka
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Hayashi Eiichi
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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Hayashi Satoru
Department Of Dermatology Faculty Of Medicine University Of Yamanashi
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YAMANAKA Kyozo
Department of Pharmacology, Fukui Medical School
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YAMADA Shizuo
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
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YAMANAKA Kyozo
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
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HAYASHI Satoru
Department of Chemical Engineering, Nagoya University
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