Effects of adenosine on contractile response of circular muscle in electrically stimulated guinea-pig ileum.
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概要
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The action of adenosine on the electrically induced mechanical response of circular muscle in isolated guinea-pig ileum has been investigated. Electrical stimulation (0.1 Hz) elicited the twitch response, which was completely abolished by tetrodotoxin (0.2 μM), morphine (1 μM) and atropine (0.1 μM). Adenosine (0.1-100 μM) markedly depressed the twitch response in a concentrationdependent manner, and the concentration-depression curve for adenosine was significantly shifted to the right in the presence of theophylline (30 μM). On the other hand, the contractile responses induced by acetylcholine (1-300 μM) were not effected by adenosine at all. The present investigation suggests that the twitch response is mediated through acetylcholine released from the intramural cholinergic nerves supplying the circular muscle of guinea-pig ileum, and adenosine has an inhibitory effect on the cholinergic transmission, probably via P<SUB>1</SUB>-purinoceptors.
- 公益社団法人 日本薬理学会の論文
著者
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Hayashi Eiichi
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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Cheng Juei-Tang
Department of Medical Research, Chi Mei Medical Center
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SHINOZUKA Kazumasa
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
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Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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CHENG Juei-Tang
Department of Pharmacology, National Cheng Kung University Medical College
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