Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effect of water extracts of Cordyceps sinensis (WECS) on Kupffer cell function in rats. Rats were received a single i.v. injection of a colloidal carbon solution and then the clearance rate from the blood were measured. The rats had been daily administered with WECS, p.o. at a dose of 200 mg/kg for 25 days until the day before the injection of colloidal carbon. The half-life of the colloidal carbon in the blood of rats administered WECS 200 mg/kg was significantly shorter than that of the control rats. This suggests that accelerated function of Kupffer cells is partially involved in the anti-metastatic action of WECS.
- 社団法人 日本薬理学会の論文
- 1999-04-01
著者
-
Nakamura Katsuya
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
KAGOTA Satomi
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
NAKAMURA Kazuki
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
KUNITOMO Masaru
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
SHINOZUKA Kazumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
Nakamura K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kunimoto M
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kunitomo Masaru
京都大学 医学研究科糖尿病・栄養内科学
-
Yamaguchi Yu
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
YAMAGUCHI Yu
Department of Pharmacology, Faculty of Pharmaceutical Sciences Mukogawa Women's University
-
Yamaguchi Yu
Department Of Obstetrics And Gynecology Tohoku University School Of Medicine
-
Nakamura Kazufumi
Faculty Of Pharmaceutical Sciences Kyushu University
-
Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Kunitomo Masaru
Department Of Pharmacology Shizuoka College Of Pharmaceutical Science
-
Nakamura Kazuki
Department Of Applied Chemistry Faculty Of Engineering Shibaura Institute Of Technology
-
Nakamura Katsuji
Tsukuba Research Laboratories Eisai Co. Ltd.
-
Shinozuka Kazumasa
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Shinozuka Kazumasa
Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Shinozuka Kazumasa
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
-
Shinozuka Kazumasa
Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University
-
Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
-
Shinozuka K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kagota Satomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Kunitomo Masaru
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Saito K
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
-
Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
関連論文
- Effects of Dietary Ingredients on Function and Expression of P-Glycoprotein in Human Intestinal Epithelial Cells
- Characterization of cardiac size and function in SHRSP.Z-Lepr[fa]/IzmDmcr rats, a new animal model of metabolic syndrome
- Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats(Pharmacology)
- Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
- Safety of Dietary Supplements:Chronotropic and Inotropic Effects on Isolated Rat Atria
- Biochemical Evidence of Atherosclerosis Progression Mediated by Increased Oxidative Stress in Apolipoprotein E-Deficient Spontaneously Hyperlipidemic Mice Exposed to Chronic Cigarette Smoke
- Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome
- Long-Term Feeding of Ginkgo biloba Extract Impairs Peripheral Circulation and Hepatic Function in Aged Spontaneously Hypertensive Rats(Pharmacognosy)
- P2Y Receptor-Mediated Ca^ Signaling Increases Human Vascular Endothelial Cell Permeability
- Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function : Purinergic Modulation of Vascular Sympathetic Neurotransmission
- Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries
- Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
- Inhibitory Effect of Cordyceps sinensis on Spontaneous Liver Metastasis of Lewis Lung Carcinoma and B16 Melanoma Cells
- Beneficial Effect of Coenzyme Q10 on Increased Oxidative and Nitrative Stress and Inflammation and Individual Metabolic Components Developing in a Rat Model of Metabolic Syndrome
- Anion-exchange high-performance liquid chromatography assays of plasma lipoproteins and modified low-density lipoproteins using a ProtEx-DEAE column
- Peroxynitrite-Generating Species: Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke
- High-performance liquid chromatographic assay of hydroperoxide levels in oxidatively modified lipoproteins
- Anion-exchange high-performance liquid chromatographic assay of plasma lipoproteins of rabbits, rats and mice
- Regional Differences in Noradrenaline-Induced Release of Adenosine Triphosphate from Rat Vascular Endothelium
- Characterization of Cardiac Size and Function in SHRSP.Z-Leprfa/IzmDmcr Rats, a New Animal Model of Metabolic Syndrome
- Highly Sensitive Measurement of P-Glycoprotein-Mediated Transport Activity in Caco-2 Cells
- Effect of Vanadate on ATP-Induced Increase in Intracellular Calcium Ion Levels in Human Umbilical Vein Endothelial Cells
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line(Biochemistry)
- Studies on Anti-inflammatory Agents. VI. Synthesis and Pharmacological Properties of 2,3-Diarylthiophenes
- Studies on Anti-inflammatory Agents. V. Synthesis and Pharmacological Properties of 3-(Difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole and Related Compounds
- Studies on Anti-inflammatory Agents. IV. Synthesis and Pharmacological Properties of 1,5-Diarylpyrazoles and Related Derivatives
- Synthesis and Evaluation of Novel Pyrimido-Acridone, -Phenoxadine, and -Carbazole as Topoisomerase II Inhibitors
- A novel carbazole topoisomerase II poison, ER-37328 : potent tumoricidal activity against human solid tumors in vitro and in vivo
- Immunological Effects of Recombinant Feline Interferon-ω (KT-80) Administration in the Dog
- THE SIGNIFICANCE OF NONSTRESS TEST FROM 24 TO 42 WEEKS' GESTATION
- Oxidants in the Gas Phase of Cigarette Smoke Pass Through the Lung Alveolar Wall and Raise Systemic Oxidative Stress
- Melatonin Inhibits the Central Sympatho-adrenomedullary Outflow in Rats
- EFFECT OF SHAKUYAKU-KANZOH-TOH, A PRESCRIPTION COMPOSED OF SHAKUYAKU (PAEONIAE RADIX) AND KANZOH (GLYCYRRHIZAE RADIX) ON GUINEA PIG ILEUM
- Microfluidic Polymer Chip with an Embedded Ion-Selective Electrode Detector for Nitrate-Ion Assay in Environmental Samples
- Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice(Pharmacognosy)
- Activation of Inwardly Rectifying K^+ Channel in OK Proximal Tubule Cells Involves cGMP-Dependent Phosphorylation Process
- Involvement of Inducible Nitric Oxide Synthase in Blood Flow Decrease in Vein Induced by Hen-Egg White Lysozyme(Miscellaneous)
- Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease(Miscellaneous)
- Ginkgo biloba Extract markedly Induces Pentoxyresorufin O-Dealkylase Activity in Rats
- Endothelin ET_A- and ET_B-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach
- Modulation of the Ca^-Activated Large Conductance K^+ Channel by Intracellular pH in Human Renal Proximal Tubule Cells
- Effect of Additives on Dissolution and Swelling of Soybean Lecithin Microcapsules Prepared Using the Wurster Process
- Phase Separation in Microcapsule Membranes Composed of Soybean Lecithin, Cholesterol, Stearic Acid and Polyvinylpyrrolidone
- Regulation of Inwardly Rectifying K^+ Channel in Cultured Opossum Proximal Tubule Cells by Protein Phosphatases 1 and 2A
- Isolation and Structure of Four New Ceramides from the Starfish Luidia maculata
- Isolation and Structure Determination of Six Glucocerebrosides from the Starfish Luidia maculata
- Changes of Contractile Properties of Extensor Digitorum Longus in Response to Creatine-Analogue Administration and/or Hindlimb Suspension in Rats
- Effects of Chronic Iron Deficiency Anemia on Brain Metabolism
- Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline
- POSSIBILITIES FOR ADENOSINE MODULATION OF PERISTALTIC REFLEX IN GUINEA PIG ISOLATED ILEUM
- PHYSIOLOGICAL IMPLICATION OF THE L-ARGININE-NITRIC OXIDE PATHWAY IN CIRCULATION
- Role of K^+ Channels in M_2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach
- Product Analyses of Ozone Mediated Nitration of Benzimidazole Derivatives with Nitrogen Dioxide : Formation of 1-Nitrobenzimidazoles and Conversion to Benzotriazoles
- Participation of Endogenous Noradrenaline in the Relaese of ATP by High Potassium in the Rat Caudal Artery
- Nicotinamide Derivatives as a New Class of Gastric (H^+/K^+)-ATPase Inhibitors. III. Synthesis and Gastric Antisecretory Activity of 2-[(2- and 4-Aminobenzyl, and α-methylbenzyl)sulfinyl]-N-(4-pyridinyl)-3-pyridinecarboxamides
- Nicotinamide Derivatives as a New Class of Gastric (H^+/k^+)-ATPase Inhibitors. II. Synthesis and Structure-Activity Relationships of 2-[(2,4-Dimethoxybenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3-carboxamides
- THE INFLUENCE OF EXTRACELLULAR Ca2+ CONCENTRATION ON THE INHIBITORY EFFECT OF ADENOSINE IN GUINEA-PIG ILEAL LONGITUDINAL MUSCLES
- Involvement of Endogenous Nitric Oxide in the Regulation of K^+ Channel Activity in Cultured Human Proximal Tubule Cells
- EXPERIMENTAL ATHEROSCLEROSIS IN RATS FED A VITAMIN D, CHOLESTEROL-RICH DIET
- Toxicologic Investigation of Dimethylacrylamide in Mice
- FUNDAMENTAL STUDIES OF ANTHELMINTICS (XXII). ELECTROPHYSIOLOGICAL STUDIES OF 1-[2-(DODECYLOXY) ETHYL]PYRROLIDINE HYDROCHLORIDE (DEP) ON ASCARIS MUSCLE CELLS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
- An ATP-Regulated and pH-Sensitive Inwardly Rectifying K^+ Channel in Cultured Human Proximal Tubule Cells
- Properties of a Ca^-Activated Large Conductance K^+ Channel with ATP Sensitivity in Human Renal Proximal Tubule Cells
- Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome
- Effects of Functional Food Constituents on P-glycoprotein Activity in Caco-2 Cells Determined by a New Method Using Confocal Laser Scanning Microscopy
- Effects of Short-term Ginkgo Biloba Extract Feeding on Hypotensive Action of Nicardipine in Rats
- Effects of cytokines on potassium channels in renal tubular epithelia
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line
- Reaction Mechanism and Improved Performance of Solution-Based Electrochemiluminescence Cell Driven by Alternating Current
- Advantage of Immobilization of Phthalate Derivatives on Indium Tin Oxide Electrode over TiO
- Effects of Cholesterol Loading on Autoimmune MRL-lpr/lpr Mice. Susceptibility to Hypercholesterolemia and Aortic Cholesterol Deposition.
- Pharmacological Analysis of Receptors Involved in the Late, Tachykininergic Contractile Response to Electrical Transmural Stimulation in Isolated Rabbit Iris Sphincter Muscle.
- Possible Participation of ATP in Changes of Blood Pressure in SHR and Old Rats
- Changes of platelet functions due to spontaneous hypertension: Reduced responses to Ionophore A23187 in SHRSP platelets
- Hyperlipidemic effects of adriamycin in rats.
- Suppression of adjuvant arthritis in rats by cholesterol.
- Abnormal lipid metabolism in adjuvant arthritic rats.
- Enhancing activity of anthranilic acid on adjuvant arthritis in rats and antibody formation in mice.
- Cholesterol reduces and corticosteroids enhance the toxicity of vitamin D in rats.
- Changes of platelet functions due to spontaneous hypertention: Effects of OP/CPK and/or ASA on platelet aggregation in SHRSP and WKY
- Hypertensive Effects of Nitroarginine:Comparison between WKY and SHRSP
- P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability
- Changes in Platelet Functions due to Hypertension in The Rat VI. Comparison of Experimental Hypertension with Spontaneous Hypertension
- A Uniform Alteration in Serum Lipid Metabolism Occurring during Inflammation in Mice.
- Effects of adenosine on contractile response of circular muscle in electrically stimulated guinea-pig ileum.
- Lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia.
- Cholesterol metabolism in serum and aorta of inbred mice fed a high-cholesterol diet.
- Impairment of Endothelium-Dependent Relaxation in Aorta from Rats with Arteriosclerosis Induced by Excess Vitamin D and a High-Cholesterol Diet.
- Altered Vasoconstrictor Responsiveness in Vitamin D-Induced Arteriosclerotic Rat Aortas.
- Atherosclerosis mouse model induced by a high-cholesterol diet supplemented with .BETA.-aminopropionitrile: Effects of various anti-atherosclerotic agents on the biochemical parameters.
- Enthalpies of Hydrogen Bond Formation between Diphenylamines and Dimethyl Sulfoxide
- Determination of the Effects of Green Tea Extract and Fruit Extracts on P-glycoprotein Activity in Caco-2 Cells by Using a New Method Involving Confocal Laser Scanning Microscopy
- Effect of amide bond in gate dielectric polymers on memory performance of organic field-effect transistors