Suppression of adjuvant arthritis in rats by cholesterol.
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概要
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Dietary cholesterol suppressed adjuvant arthritis, a chronic inflammatory disease, in rats, but did not significantly affect carrageenin edema, an acute inflammation. When rats were fed a high-cholesterol diet beginning 10 days before injection of adjuvant, the development of the adjuvant-induced arthritis was greatly suppressed. Cholesterol feeding prevented hypertrophy of the adrenal gland in arthritic rats, but had little influence on the serum corticosterone level. A significant positive correlation was observed between the adrenal weight and the severity of the arthritis. These findings suggest that the effect of cholesterol feeding is not due to increased adrenal sterol synthesis. Dietary cholesterol also prevented hypertrophy of the spleen, but had no effect on atrophy of the thymus in adjuvant-treated rats. Cholesterol-fed rats showed a significant decrease in the serum lipid peroxide level and a significant increase in the serum copper level. Adjuvant treatment not only enhanced hypercholesterolemia produced by cholesterol feeding, but also the level of free cholesterol in serum. These results suggest that dietary cholesterol may exert some effect on the immune response through changes in spleen and liver functions.
- 公益社団法人 日本薬理学会の論文
著者
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Yamaguchi Yu
Department Of Obstetrics And Gynecology Tohoku University School Of Medicine
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Bando Yoshio
Department Of Anatomy 1 Asahikawa Medical College
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FUTAGAWA Yoshiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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HAMAGUCHI Yoshiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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FUTAGAWA Yoshiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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HAMAGUCHI Yoshiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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