EXPERIMENTAL ATHEROSCLEROSIS IN RATS FED A VITAMIN D, CHOLESTEROL-RICH DIET
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概要
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Atherosclerotic lesions of the aorta and coronary arteries were induced in rats fed a diet supplemented with cholesterol and vitamin D_2 for 8 weeks. Rats fed a purified diet supplemented with 1% cholesterol and 1.25 million units of vitamin D_2/kg of diet showed cholesterol deposition in the aorta but no abnormal findings were observed either macroscopically or microscopically in the aorta and coronary arteries. Rats fed a diet supplemented with 1.5% cholesterol and 1.8 million units of vitamin D_2/kg of diet showed not only marked deposition of cholesterol and calcium but also extensive macroscopic lesions of atherosclerosis in the aorta and coronary arteries. No significant deposition of cholesterol and calcium in the aorta of rats fed the diet without the vitamin D_2 supplement was observed in either experiment.
- 公益社団法人日本薬学会の論文
著者
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Bando Yoshio
Department Of Electrical Engineering Kure National College Of Technology
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Kinoshita Kyoko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Kinoshita Kyoko
Department Of Biology Faculty Of Science Toho University
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Bando Yoshio
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Bando Yoshio
Department Of Anatomy 1 Asahikawa Medical College
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