Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
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概要
- 論文の詳細を見る
We previously demonstrated that Ginkgo biloba extract (GBE) produced vasodilation via the nitric oxide synthesis and release by increasing the intracellular calcium level in vascular endothelial cells of rats. The present study aimed to clarify the effects of dietary administration of GBE on the blood pressure and vascular tone of hypertensive Dahl salt-sensitive (Dahl) rats in order to evaluate its therapeutic actions and availability. Dahl rats were fed an 8.0% NaCl diet or an 8.0% NaCl plus 0.5% GBE diet for 24d. The feeding of GBE did not change the heart rate, but significantly decreased systolic blood pressure. After 24 days' administration, the effects of GBE on the atria and aorta isolated from Dahl rats were examined. The GBE-containing diet did not affect the negative and positive actions of isolated atria that were produced by acetylcholine and isoproterenol, respectively. In the aortic preparations, the relaxation in response to acetylcholine was significantly potentiated by a GBE-containing diet. Sodium nitroprusside-induced relaxation was unchanged by GBE-containing diet. These results demonstrated that GBE reduced salt-related elevation of blood pressure and restored the impaired acetyl-choline-induced vasodilation in aortic segments.
- 社団法人日本薬学会の論文
- 2006-02-01
著者
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Nakamura Katsuya
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Umegaki Keizo
The National Institute Of Health And Nutrition
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Umegaki Keizo
National Institute Of Health And Nutrition
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Umegaki Keizo
静岡県立大学 生活健康科研究
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KUBOTA Yoko
Department of Biopharmaceutics, Nihon Pharmaceutical University
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KAGOTA Satomi
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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TANAKA Naoko
Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfa
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NAKAMURA Kazuki
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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KUNITOMO Masaru
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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SHINOZUKA Kazumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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Tanaka N
Department Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's University
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Tanaka Naoko
武庫川女子大学 薬学部薬理学
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Nakamura K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Kunimoto M
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Kunitomo Masaru
京都大学 医学研究科糖尿病･栄養内科学
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Kubota Y
Department Of Biopharmaceutics Nihon Pharmaceutical University
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Tanaka Naoko
Department Of Obstetrics And Gynecology Institute Of Health Biosciences The University Of Tokushima
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中西 務
Faculty Of Pharmaceutical Sciences Setsunan University
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Nakamura Kazufumi
Faculty Of Pharmaceutical Sciences Kyushu University
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Tanaka N
School Of Pharmaceutical Sciences Mukogawa Women S University
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Kunitomo Masaru
Department Of Pharmacology Shizuoka College Of Pharmaceutical Science
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Nakamura Kazuki
Department Of Applied Chemistry Faculty Of Engineering Shibaura Institute Of Technology
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Nakamura Katsuji
Tsukuba Research Laboratories Eisai Co. Ltd.
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Shinozuka Kazumasa
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Shinozuka Kazumasa
Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
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Shinozuka Kazumasa
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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Shinozuka Kazumasa
Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University
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Umegaki K
National Institute Of Health And Nutrition
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Umegaki Keizo
The National Institute Of Health And Nutrition Shinjuku-ku
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UMEGAKI Keizo
IAA National Institute of Health and Nutrition
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Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
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Shinozuka K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Kwon Young
Department Of Biopharmaceutics Nihon Pharmaceutical University
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Kagota Satomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Umegaki Keizo
National Inst. Of Health And Nutrition
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Kunitomo Masaru
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
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Nishimata Toyoki
R & D Division Daiichi Sankyo Co. Ltd.
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Saito K
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
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TANAKA Naoko
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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