Biochemical Evidence of Atherosclerosis Progression Mediated by Increased Oxidative Stress in Apolipoprotein E-Deficient Spontaneously Hyperlipidemic Mice Exposed to Chronic Cigarette Smoke
スポンサーリンク
概要
- 論文の詳細を見る
Cigarette smoking is a major risk factor for cardiovascular disease. The induction of oxidative stress by smoking plays a key role in the progression of atherosclerosis. However, the underlying mechanisms are not fully understood. In the present study, we investigated whether long-term smoking can accelerate the progression of atherosclerosis and whether oxidative stress is implicated in its pathogenesis. Apolipoprotein E–deficient spontaneously hyperlipidemic mice, a model of atherosclerosis, were exposed to the gas-phase of smoke, from which tar and nicotine had been removed, for 15 min a day, 6 days a week, for 16 weeks. Exposure to cigarette smoke significantly increased the serum levels of oxidative stress markers such as thiobarbituric acid–reactive substances, oxidatively modified low-density lipoproteins, and 3-nitrotyrosine, but it did not affect serum cholesterol and triglyceride levels. Exposure to smoke also accelerated the accumulation of total cholesterol levels in the aorta that was accompanied by an increase in 3-nitrotyrosine levels of the atherosclerotic mice. These changes in the serum and aorta that progressed with exposure to smoke were prevented by vitamin E administration. Our data suggest that chronic cigarette smoking promotes and aggravates atherosclerosis and that the antioxidant vitamin E exerts an anti-atherogenic effect via reduction of oxidative stress.
- 社団法人 日本薬理学会の論文
- 2009-07-20
著者
-
Nakamura Katsuya
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
NAKAMURA Kazuki
School of Pharmaceutical Sciences, Mukogawa Women's University
-
KUNITOMO Masaru
School of Pharmaceutical Sciences, Mukogawa Women's University
-
Nakamura K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kunimoto M
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kunitomo Masaru
京都大学 医学研究科糖尿病・栄養内科学
-
Yamaguchi Yu
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
YAMAGUCHI Yu
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
-
KAGOTA Satomi
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
-
YOSHIKAWA Noriko
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
-
SHINOZUKA Kazumasa
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
-
Yamaguchi Yu
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
-
Nakamura Kazufumi
Faculty Of Pharmaceutical Sciences Kyushu University
-
Kunitomo Masaru
School Of Pharmaceutical Sciences Mukogawa Women's University
-
Kunitomo Masaru
Department Of Pharmacology Shizuoka College Of Pharmaceutical Science
-
Yoshikawa Noriko
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
-
Nakamura Katsuji
Tsukuba Research Laboratories Eisai Co. Ltd.
-
Shinozuka Kazumasa
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Shinozuka Kazumasa
Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Shinozuka Kazumasa
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
-
Shinozuka Kazumasa
School Of Pharmaceutical Sciences Mukogawa Women S University
-
Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
-
Shinozuka K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kagota Satomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Kunitomo Masaru
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Saito K
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
関連論文
- Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats(Pharmacology)
- Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
- Safety of Dietary Supplements:Chronotropic and Inotropic Effects on Isolated Rat Atria
- The Bitterness Intensity of Clarithromycin Evaluated by a Taste Sensor
- Biochemical Evidence of Atherosclerosis Progression Mediated by Increased Oxidative Stress in Apolipoprotein E-Deficient Spontaneously Hyperlipidemic Mice Exposed to Chronic Cigarette Smoke
- Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome
- Long-Term Feeding of Ginkgo biloba Extract Impairs Peripheral Circulation and Hepatic Function in Aged Spontaneously Hypertensive Rats(Pharmacognosy)
- P2Y Receptor-Mediated Ca^ Signaling Increases Human Vascular Endothelial Cell Permeability
- Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function : Purinergic Modulation of Vascular Sympathetic Neurotransmission
- Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries
- Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
- Inhibitory Effect of Cordyceps sinensis on Spontaneous Liver Metastasis of Lewis Lung Carcinoma and B16 Melanoma Cells
- Beneficial Effect of Coenzyme Q10 on Increased Oxidative and Nitrative Stress and Inflammation and Individual Metabolic Components Developing in a Rat Model of Metabolic Syndrome
- Anion-exchange high-performance liquid chromatography assays of plasma lipoproteins and modified low-density lipoproteins using a ProtEx-DEAE column
- Peroxynitrite-Generating Species: Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke
- High-performance liquid chromatographic assay of hydroperoxide levels in oxidatively modified lipoproteins
- Anion-exchange high-performance liquid chromatographic assay of plasma lipoproteins of rabbits, rats and mice
- Regional Differences in Noradrenaline-Induced Release of Adenosine Triphosphate from Rat Vascular Endothelium
- Characterization of Cardiac Size and Function in SHRSP.Z-Leprfa/IzmDmcr Rats, a New Animal Model of Metabolic Syndrome
- Highly Sensitive Measurement of P-Glycoprotein-Mediated Transport Activity in Caco-2 Cells
- Effect of Vanadate on ATP-Induced Increase in Intracellular Calcium Ion Levels in Human Umbilical Vein Endothelial Cells
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line(Biochemistry)
- Effect of Quinine Solutions on Intracellular Ca^Levels in Neuro-2a Cells : Conventional Physiological Method for the Evaluation of Bitterness(Miscellaneous)
- Studies on Anti-inflammatory Agents. VI. Synthesis and Pharmacological Properties of 2,3-Diarylthiophenes
- Studies on Anti-inflammatory Agents. V. Synthesis and Pharmacological Properties of 3-(Difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole and Related Compounds
- Studies on Anti-inflammatory Agents. IV. Synthesis and Pharmacological Properties of 1,5-Diarylpyrazoles and Related Derivatives
- Synthesis and Evaluation of Novel Pyrimido-Acridone, -Phenoxadine, and -Carbazole as Topoisomerase II Inhibitors
- A novel carbazole topoisomerase II poison, ER-37328 : potent tumoricidal activity against human solid tumors in vitro and in vivo
- Melatonin Inhibits the Central Sympatho-adrenomedullary Outflow in Rats
- EFFECT OF SHAKUYAKU-KANZOH-TOH, A PRESCRIPTION COMPOSED OF SHAKUYAKU (PAEONIAE RADIX) AND KANZOH (GLYCYRRHIZAE RADIX) ON GUINEA PIG ILEUM
- Activation of Inwardly Rectifying K^+ Channel in OK Proximal Tubule Cells Involves cGMP-Dependent Phosphorylation Process
- Involvement of Inducible Nitric Oxide Synthase in Blood Flow Decrease in Vein Induced by Hen-Egg White Lysozyme(Miscellaneous)
- Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease(Miscellaneous)
- Ginkgo biloba Extract markedly Induces Pentoxyresorufin O-Dealkylase Activity in Rats
- Endothelin ET_A- and ET_B-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach
- Modulation of the Ca^-Activated Large Conductance K^+ Channel by Intracellular pH in Human Renal Proximal Tubule Cells
- Effect of Additives on Dissolution and Swelling of Soybean Lecithin Microcapsules Prepared Using the Wurster Process
- Phase Separation in Microcapsule Membranes Composed of Soybean Lecithin, Cholesterol, Stearic Acid and Polyvinylpyrrolidone
- Regulation of Inwardly Rectifying K^+ Channel in Cultured Opossum Proximal Tubule Cells by Protein Phosphatases 1 and 2A
- Isolation and Structure of Four New Ceramides from the Starfish Luidia maculata
- Isolation and Structure Determination of Six Glucocerebrosides from the Starfish Luidia maculata
- Changes of Contractile Properties of Extensor Digitorum Longus in Response to Creatine-Analogue Administration and/or Hindlimb Suspension in Rats
- Effects of Chronic Iron Deficiency Anemia on Brain Metabolism
- Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline
- POSSIBILITIES FOR ADENOSINE MODULATION OF PERISTALTIC REFLEX IN GUINEA PIG ISOLATED ILEUM
- Role of K^+ Channels in M_2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach
- Product Analyses of Ozone Mediated Nitration of Benzimidazole Derivatives with Nitrogen Dioxide : Formation of 1-Nitrobenzimidazoles and Conversion to Benzotriazoles
- Nicotinamide Derivatives as a New Class of Gastric (H^+/K^+)-ATPase Inhibitors. III. Synthesis and Gastric Antisecretory Activity of 2-[(2- and 4-Aminobenzyl, and α-methylbenzyl)sulfinyl]-N-(4-pyridinyl)-3-pyridinecarboxamides
- Nicotinamide Derivatives as a New Class of Gastric (H^+/k^+)-ATPase Inhibitors. II. Synthesis and Structure-Activity Relationships of 2-[(2,4-Dimethoxybenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3-carboxamides
- Involvement of Endogenous Nitric Oxide in the Regulation of K^+ Channel Activity in Cultured Human Proximal Tubule Cells
- Toxicologic Investigation of Dimethylacrylamide in Mice
- An ATP-Regulated and pH-Sensitive Inwardly Rectifying K^+ Channel in Cultured Human Proximal Tubule Cells
- Properties of a Ca^-Activated Large Conductance K^+ Channel with ATP Sensitivity in Human Renal Proximal Tubule Cells
- Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome
- Effects of Functional Food Constituents on P-glycoprotein Activity in Caco-2 Cells Determined by a New Method Using Confocal Laser Scanning Microscopy
- Effects of Short-term Ginkgo Biloba Extract Feeding on Hypotensive Action of Nicardipine in Rats
- Effects of cytokines on potassium channels in renal tubular epithelia
- A Chemical Approach to Searching for Bioactive Ingredients in Cigarette Smoke
- Possible Participation of ATP in Changes of Blood Pressure in SHR and Old Rats
- Methyl Vinyl Ketone, a Toxic Ingredient in Cigarette Smoke Extract, Modifies Glutathione in Mouse Melanoma Cells
- Determination of the Effects of Green Tea Extract and Fruit Extracts on P-glycoprotein Activity in Caco-2 Cells by Using a New Method Involving Confocal Laser Scanning Microscopy