Studies on Anti-inflammatory Agents. VI. Synthesis and Pharmacological Properties of 2,3-Diarylthiophenes
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概要
- 論文の詳細を見る
A series of novel 5-substituted-2,3-diarylthiophenes has been synthesized and found to be active in the rat adjuvant arthritis (AA) model and/or in the yeast-induced hyperalgesia (Randall-Selitto) assay. Among the compounds synthesized herein, 2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)thiophene (6a) exhibited the most potent activities on AA, collagen-induced arthritis (CIA) and the delayed-type hypersensitivity response to type II collagen. 5-Bromo-2-[4-(methylamino)phenyl]-3-[4-(methylsulfinyl)phenyl]thiophene (38) is also a potent inhibitor of AA, CIA, hyperalgesia and in vitro tumor necrosis factor-α production.
- 社団法人日本薬学会の論文
- 1998-02-15
著者
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辻 浩一
Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.
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Nakamura Katsuya
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Ochi Takehiro
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nakamura K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Tsuji Kiyoshi
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Ochi Takehiro
Medicinal Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Ogino T
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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OGINO Takashi
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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KONISHI Nobukiyo
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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TOJO Takashi
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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SEKI Nobuo
Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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MATSUO Masaaki
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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Seki Nobuo
Medicinal Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Matsuo Masaaki
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nakamura Kazufumi
Faculty Of Pharmaceutical Sciences Kyushu University
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TOJO Takashi
Research Laboratory, Higeta Shoyu Co., Ltd.
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Nakamura Katsuji
Tsukuba Research Laboratories Eisai Co. Ltd.
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Tsuji K
School Of Pharmaceutical Science University Of Shizuoka
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辻 京子
Faculty Of Pharmaceutical Sciences Setsunan University
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Tojo T
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Tojo Takashi
Research Laboratory Higeta Shoyu Co. Ltd.
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Tojo Takashi
Up Educational Project
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Ogino T
Research Division Discovery Research Laboratories Ii Sumitomo Pharmaceuticals Co. Ltd.
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Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
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Konishi N
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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