Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries

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概要

• 論文の詳細を見る

• The effects of purinoceptor agonists on noradrenaline NA release by electrical stimulation in rat mesenteric arteries were examined to clarify the pharmacological properties of prejunctional purinoceptors on adrenergic nerves. Adenosine and the other P1-receptor agonists, 5-(N-ethylcarboxamido) adenosine and 2-chloroadenosine, significantly inhibited the release of NA. Also β, γ-methylene ATP and 2-methylthio ATP, P2-receptor agonists, significantly inhibited NA releases. The inhibitory effect of adenosine was significantly reduced by adenosine deaminase, but those of β,γ-methylene ATP and 2-methylthio ATP were not affected. This suggests that the inhibitory effects of P2-receptor agonists are not due to conversion into adenosine. 1,3-Dipropyl-8-cyclopentylxanthine (DPCPX), a P1 (A1)-receptor antagonist, significantly reduced the inhibitory effects of not only the P1- but also P2-receptor agonists. Therefore, DPCPX appears to act on both prejunctional P1- and P2-receptor as an antagonist. Pyridoxalphosphate-6-azophenyl-2,4-disulfonic acid (PPADS), a P2-receptor antagonist, significantly reduced the inhibitory effects of the P2-receptor agonists, but not those of the P1-receptor agonists. From these findings in the rat mesenteric artery, the P1-receptor agonist-induced inhibition of NA-release appears to be mediated via a well-known prejunctional P1-receptor of the A1-subtype, but the P2-receptor agonist-induced inhibition appears to be mediated via an unidentified purinoceptor that is blocked not only by P2-receptor antagonists but also by P1-receptor antagonists.

• 社団法人 日本薬理学会の論文
• 2001-01-01

著者

• Nakamura Katsuya

  Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• KWON Young

  Department of Mechano-Informatics & Design Engineering, Hongik University

• KUBOTA Yoko

  Department of Biopharmaceutics, Nihon Pharmaceutical University

• TANAKA Naoko

  Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfa

• NAKAMURA Kazuki

  Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University

• KUNITOMO Masaru

  Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University

• SHINOZUKA Kazumasa

  Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University

• Tanaka N

  Department Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's University

• Tanaka Naoko

  武庫川女子大学 薬学部薬理学

• Nakamura K

  Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ

• Kunimoto M

  Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ

• Kunitomo Masaru

  京都大学 医学研究科糖尿病･栄養内科学

• Kubota Y

  Department Of Biopharmaceutics Nihon Pharmaceutical University

• TANIOKA Yoshie

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University

• Tanioka Yoshie

  武庫川女子大学 薬 薬理

• Tanioka Yoshie

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Tanaka Naoko

  Department Of Obstetrics And Gynecology Institute Of Health Biosciences The University Of Tokushima

• 中西 務

  Faculty Of Pharmaceutical Sciences Setsunan University

• Nakamura Kazufumi

  Faculty Of Pharmaceutical Sciences Kyushu University

• Tanaka N

  School Of Pharmaceutical Sciences Mukogawa Women S University

• Kunitomo Masaru

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University

• Kunitomo Masaru

  Department Of Pharmacology Shizuoka College Of Pharmaceutical Science

• Nakamura Kazuki

  Department Of Applied Chemistry Faculty Of Engineering Shibaura Institute Of Technology

• Nakamura Katsuji

  Tsukuba Research Laboratories Eisai Co. Ltd.

• Shinozuka Kazumasa

  Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ

• Shinozuka Kazumasa

  Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn

• Shinozuka Kazumasa

  Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences

• Shinozuka Kazumasa

  Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University

• Nakamura K

  Department Of Physiology Ii Iwate Medical University School Of Medicine

• Shinozuka K

  Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ

• Kwon Young

  Department Of Biopharmaceutics Nihon Pharmaceutical University

• Kunitomo Masaru

  Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn

• Nishimata Toyoki

  R & D Division Daiichi Sankyo Co. Ltd.

• TANAKA Naoko

  Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Shinozuka Kazumasa

  Department of Applied Chemistry, Faculty of Engineering, Yokohama National University

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