Peroxynitrite-Generating Species: Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke
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概要
- 論文の詳細を見る
Cigarette smoking is a well−known risk factor for atherosclerosis, but the mechanism of the adverse biological effect of smoking remains to be established.Cigarette smoke contains high concentrations of free radicals and oxidants.We show here that cigarette smoke extracts(CSE), prepared by bubbling the gas phase of smoke into phosphate−buffered saline, could convert tyrosine to 3−nitrotyrosine.The tyrosine nitration terminated 6 h after incubating tyrosine with CSE at 37°C.These results indicate that the active oxidants in CSE are peroxynitrite−generating species like 3−morpholinosydnonimine(SIN−1), suggesting that they modify plasma lipoproteins and contribute to the pathogenesis of atherosclerosis.
- 社団法人 日本薬理学会の論文
- 2000-01-01
著者
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KAGOTA Satomi
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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KUNITOMO Masaru
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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Kunimoto M
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Yamaguchi Yu
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
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YAMAGUCHI Yu
Department of Pharmacology, Faculty of Pharmaceutical Sciences Mukogawa Women's University
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HAGINAKA Jun
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Yamaguchi Yu
Department Of Obstetrics And Gynecology Tohoku University School Of Medicine
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Kunitomo Masaru
Department Of Pharmacology Shizuoka College Of Pharmaceutical Science
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Kagota Satomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Kunitomo Masaru
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
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Saito K
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
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