Characterization of Cardiac Size and Function in SHRSP.Z-Leprfa/IzmDmcr Rats, a New Animal Model of Metabolic Syndrome
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概要
- 論文の詳細を見る
Cardiac structural and functional abnormalities are observed in metabolic syndrome. However, such changes have not been investigated in the SHRSP.Z-Leprfa/IzmDmcr rat (SHRSP-fatty) model of metabolic syndrome. Here we compare cardiac size and hemodynamic function in these rats with their lean littermates (SHRSP) and normotensive control Wistar-Kyoto rats (WKY). In male 16-week-old SHRSP-fatty, we determined heart rate and systolic blood pressure (SBP) by tail-cuff, cardiac output (CO), subcutaneous peripheral blood flow (BF) and stroke volume (SV) by plethysmography, and systolic and diastolic functions by echocardiography. We also assessed weight and collagen type I expression by Western blot in isolated atrium and ventricle, and beat rate in isolated atrial preparation by myography. Heart rate was lower in conscious SHRSP-fatty than SHRSP, and the beat rate of isolated atria was lower in SHRSP-fatty and SHRSP than that of WKY. Atrial weight was larger in SHRSP-fatty than others. Ventricular weight of SHRSP-fatty and SHRSP was larger than WKY. There were significant inverse correlations between atrial weight and heart rate or beat rate in SHRSP-fatty. SBP, CO, BF and SV were increased in SHRSP-fatty similarly to SHRSP. Increased deceleration time and decreased E/A ratio, and preserved fractional shortening were observed in SHRSP-fatty. Expressions of collagen type I were increased in atria and ventricle of SHRSP-fatty. SHRSP-fatty with metabolic syndrome exhibit cardiac changes, including slowed heart rate, ventricular diastolic dysfunction, and fibrosis, and atrial enlargement. SHRSP-fatty may be a useful rat model to study on cardiac abnormalities in metabolic syndrome.
著者
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MATSUMOTO Mika
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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TSUJINO Takeshi
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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NAITO Yoshiro
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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MASUYAMA Tohru
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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KAGOTA Satomi
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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SHINOZUKA Kazumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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Masuyama Tohru
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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TADA Yukari
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's Univers
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NEJIME Namie
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's Univers
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Tsujino Takeshi
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Matsumoto Mika
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Naito Yoshiro
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Shibata Hiromi
Department of Clinical Laboratory, Hyogo College of Medicine Hospital
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Koshiba Masahiro
Department of Clinical Laboratory, Hyogo College of Medicine Hospital
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Masutani Mitsuo
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Masutani Motomaru
First Department Of Internal Medicine Hyogo College Of Medicine
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Shinozuka Kazumasa
Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University
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Masutani Motomaru
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Kagota Satomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Koshiba Masahiro
Department Of Clinical Laboratory Medicine Hyogo College Of Medicine
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Shibata Hiromi
Department Of Clinical Labolatory And Clinical Pathology Hyogo College Of Medicine
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Saito K
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's University
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MASUYAMA TOHRU
Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine
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Tada Yukari
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
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Shinozuka Kazumasa
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
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Matsumoto Mika
Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine
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Kagota Satomi
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
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Naito Yoshiro
Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine
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Nejime Namie
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
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Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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Nejime Namie
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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