Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline
スポンサーリンク
概要
- 論文の詳細を見る
Purines of ATP, ADP, AMP and adenosine released from rat caudal artery with and without endothelium and the isolated smooth muscle and endothelial cells were examined, in order to determine the source. Treatment of intact segments of caudal arteries with noradrenaline (10μM) for 3 min induced a large release of ATP, ADP, AMP and adenosine. However, if the artery segments had been denuded of their endothelial lining, noradrenaline induced only a slight release of purines. Endothelial cells in primary culture prepared from caudal arteries, when exposed to noradrenaline for 3 min released large amounts of purines, whereas vascular smooth muscle cells prepared similarly and passaged endothelial cells did not release purines upon exposure to noradrenaline. These results indicate that, of smooth muscle and endothelial cells of the vascular wall, only intact endothelial cells react to α-adrenoceptor stimulation by releasing adenine nucleotides and adenosine.
- 日本平滑筋学会の論文
著者
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SHINOZUKA Kazumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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HASHIMOTO Michio
Department of Physiology, Shimane Medical University
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MASUMURA Sumio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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BJUR Richard
Department of Pharmacology, University of Nevada School of Medicine
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WESTFALL David
Department of Pharmacology, University of Nevada School of Medicine
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HONDA MASAAKI
The 4th Department of Internal Medicine, Shimane Medical University
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Bjur Richard
Department Of Pharmacology University Of Nevada School Of Medicine
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Honda Masaaki
The 4th Department Of Internal Medicine Shimane Medical University
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Westfall David
Department Of Pharmacology University Of Nevada School Of Medicine
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HATTORI Keisuke
Department of Cardiovascular Surgery, Gifu Prefectural Tajimi Hospital
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Hashimoto Michio
Department Of Physiology Shimane Medical University
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Hashimoto Michio
Department Of Environmental Physiology Faculty Of Medicine Shimane University
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Shinozuka Kazumasa
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Shinozuka Kazumasa
Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
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Shinozuka Kazumasa
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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Shinozuka Kazumasa
Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University
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Honda M
Waseda Univ. Jpn
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Shinozuka K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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TANAKA Yasuakira
Department of Physiology, Shimane Medical University
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ISHIDA Yukisato
Mitsubishi Kasei Institute of Life Sciences
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Ishida Yukisato
Mitsubishi Kagaku Institute Of Life Sciences
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Ishida Y
Mitsubishi Kagaku Inst. Life Sci. Tokyo Jpn
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Tanaka Yasuakira
Department Of Physiology Shimane Medical University
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Tanaka Yasuakira
Department Of Neurosurgery Kyorin University School Of Medicine
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Hattori Keisuke
Department Of Cardiovascular Surgery Gifu Prefectural Tajimi Hospital
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Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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