Activity of Phosphofructokinase during Lactate Accumulation in Rabbit Aorta
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概要
- 論文の詳細を見る
When rabbit aortic strips were incubated under anaerobic conditions (at 37℃ for 3 hours), the lactate level increased remarkably to about 10 times the level observed under aerobic conditions. In the process of lactate accumulation, the activity of phosphofructokinase increased by 5-30% of the enzymatic level observed under aerobic conditions. When adrenaline was added to the bath medium, the aortic muscle contraction was somewhat weak and the activation of phosphofructokinase was less remarkable in comparison with observations under aerobic conditions. This finding suggests that lactate accumulation in rabbit aorta suppresses the activation of phosphofructokinase in the contracting materials.
- 島根大学の論文
著者
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HASHIMOTO Michio
Department of Physiology, Shimane Medical University
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MASUMURA Sumio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Masumura Sumio
Department Of Physiology Shimane Medical University
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SATO TOSHIKO
Department of Vascular Surgery, Aichi Medical University
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Hashimoto Yoko
Department of Physiology, Yokohama City University
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Hashimoto Michio
Department Of Environmental Physiology Faculty Of Medicine Shimane University
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Sato Toshiko
Department Of Physiology Shimane Medical University
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Hashimoto Yoko
Department Of Physiology Shimane Medical University
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OHTANI FUMIO
Department of Physiology, Shimane Medical University
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Ohtani Fumio
Department Of Physiology Shimane Medical University
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Hashimoto Yoko
Department Of Medicine And Clinical Science Graduate School Of Medicine
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