Sunitinib Induced Immune Thrombocytopenia
スポンサーリンク
概要
- 論文の詳細を見る
Sunitinib is an orally administered multi-targeted tyrosine kinase inhibitor and has been approved for the treatment of advanced renal cell carcinoma (RCC). It is well known that sunitinib induces hematologic adverse events, such as neutropenia, anemia, and thrombocytopenia, primarily through myelosuppression. Here, we report that the first case of immune-thrombocytopenia occurred in a patient receiving sunitinib for the treatment of metastatic RCC. The thrombocytopenia was refractory to repeated platelet transfusion. The bone marrow aspiration study revealed an increased number of megakaryocytes. No thrombotic microangiopathy was seen. The thrombocytopenia was successfully treated with high-dose corticosteroid, although intravenous immunoglobulin administration was not effective. These findings suggest that an immune-mediated mechanism was responsible for the thrombocytopenia in this patient, which developed during sunitinib administration.
- 北関東医学会の論文
著者
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Saitoh Takayuki
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Uchiumi Hideki
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Karasawa Masamitsu
Blood Transfusion Service, Gunma University Hospital
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Nojima Yoshihisa
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Yamane Arito
群馬大学 医学系研究科生体統御内科学
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Yamane A
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
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Yamane Arito
The Third Department Of Internal Medicine Gunma University School Of Medicine
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Suzuki Kazuhiro
Department of Earth and Environmental Sciences, Nagoya University
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Matsumoto Kumiko
Department Of Internal Medicine Saiseikai Maebashi Hospital
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MURAKAMI Hirokazu
Gunma University School of Health Sciences
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Matsui Hiroshi
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Uchiumi Hideki
Department Of Applied Chemistry Nagoya Institute Of Technology
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YOKOHAMA Akihiko
Department of Medicine and Clinical Science, Gunma University School of Medicine
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MITSUI Takeki
Department of Medicine and Clinical Science, Graduate School of Medicine, Gunma University
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KOISO Hiromi
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Hashimoto Yoko
Department of Physiology, Yokohama City University
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Saitoh Takayuki
Department Of Medicine And Clinical Science Graduate School Of Medicine
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Nojima Yoshihisa
Department Of Medicine And Clinical Science Graduate School Of Medicine
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Karasawa Masamitsu
Blood Transfusion Service University Hospital Faculty Of Medicine Gunma University
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Koiso Hiromi
Department Of Medicine And Clinical Science Graduate School Of Medicine
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Hashimoto Yoko
Department Of Physiology Shimane Medical University
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Handa Hiroshi
Gunma Univ. Graduate School Of Medicine Maebashi Jpn
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Yuzuriha Akinori
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Toyama Kohtarou
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Tsukamoto Norifumi
Oncology Center, Gunma University Hospital
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Hashimoto Yoko
Department Of Medicine And Clinical Science Graduate School Of Medicine
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Yokohama Akihiko
Department Of Medicine And Clinical Science Gunma University School Of Medicine
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Suzuki Kazuhiro
Department Of Cardiovascular Surgery Yamaguchi Grand Medical Center
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Mitsui Takeki
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
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Karasawa Masamitsu
Blood Transfusion Service Faculty Of Medicine University Hospital Gunma University
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Yokohama Akihiko
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
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Tsukamoto Norifumi
Oncology Center Faculty Of Medicine University Hospital Gunma University
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Yuzuriha Akinori
Department Of Hematology Saiseikai Maebashi Hospital
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Suzuki Kazuhiro
Department of Urology, Gunma University Graduate School of Medicine
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Mitsui Tateki
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Koiso Hitomi
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Handa Hiroshi
Gunma University Graduate School of Health Sciences
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Yokohama Akihiko
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Karasawa Masamitsu
Blood Transfusion Service, Faculty of Medicine, Gunma University Hospital
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Murakami Hirokazu
Gunma University Graduate School of Health Sciences
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