Serum Thrombomodulin in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (MPO-ANCA)-Associated Vasculitis.
スポンサーリンク
概要
- 論文の詳細を見る
Background and Aims : Although serum or plasma thrombomodulin (TM) was reported to be increased in various diseases with vascular injuries, blood TM was also shown to be influenced by renal function. In this study, we determined whether serum TM (sTM) could be a marker of vascular injury in patients with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis, in which kidneys are often affected. Methods : Thirteen patients with MPO-ANCA-associated vasculitis were investigated and 43 patients with chronic glomerulonephritis (CGN) served as a control. sTM was measured by one-step sandwich enzyme immunoassay method. Results : A significant positive correlation was found between sTM and serum creatinine (sCr) (sTM=2.24×sCr+2.16, r=0.91, P<0.001) in patients with CGN. In order to correct sTM for renal function, we calculated corrected sTM according to the following formula : corrected sTM (%)=[measured sTM/expected sTM at the measured sCr]×100=[sTM/(2.24×sCr+2.16)]×100. Patients with MPO-ANCA-associated vasculitis tended to have lower levels of corrected sTM before treatment compared to patients with CGN, but not significantly (86.8±23.2% vs. 98.7±18.3%, ANCA vs. CGN, P=0.12). Corrected sTM was increased significantly within 1 month after the beginning of treatment (145.7±46.9%, P=0.008, vs. before treatment in each patient). In remission, corrected sTM returned to the same levels of CGN (104.5±38.6%, P=0.03, vs. within 1 month in each patient). Conclusions : These results showed that sTM corrected for renal function does not simply reflect disease activity in MPO-ANCA-associated vasculitis.
- 北関東医学会の論文
- 2005-02-01
著者
-
Nojima Yoshihisa
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
-
Ueki Kazue
Department of Internal Medicine, Toho Hospital
-
Hayashi Junichi
Department of Internal Medicine, School of Medicine, Keio University
-
Nojima Yoshihisa
Department Of Medicine And Clinical Science Graduate School Of Medicine
-
Ueki Kazue
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
-
Ueki K
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
-
Kaneko Yoriaki
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
-
Nakajima Yasuyo
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
-
Nojima Yoshihisa
The Third Department Of Internal Medicine Gunma University School Of Medicine
-
Nakazato Yoichi
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
-
KUROIWA Takashi
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
-
HIROMURA Keiju
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
-
Kitahara Tokuyuki
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
-
Kuroiwa Takashi
Department Of Electrical And Electronic Engineering College Of Industrial Technology Nihon Universit
-
Ueki Kazue
Department Of Internal Medicine Toho Hospital
-
Kitahara Tokuyuki
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
-
Hayashi Junichi
Department Of General Medicine School Of Medicine Kyorin University
-
Nojima Yoshihisa
Department Of Medicine And Clinical Science Gunma University School Of Medicine
-
Hiromura Keiju
Department Of Medicine And Clinical Science Gunma University School Of Medicine
-
Kuroiwa Takashi
Department Of Medicine And Clinical Science Gunma University School Of Medicine
-
Hayashi Junichi
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
-
Hayashi Junichi
Department Of General Medicine Kyorin University School Of Medicine
-
Hiromura Keiju
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
関連論文
- Successful Treatment by All-Trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia Complicated by Liver Cirrhosis and Polycystic Kidney
- Quantification of ALL-Type BCR/ABL Fusion Transcripts in Patients with Chronic Myelogenous Leukemia in Chronic Phase Using Real-Time Quantitative Polymerase Chain Reaction
- Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases
- X-Linked Agammaglobulinemia Diagnosed in Adulthood : A Case Report
- X-Linked Lymphoproliferative Disease in an Adult
- THE PROTECTION OF THE ISCHEMIC MYOCARDIUM WITH CoQ10 : Cardiovascular Drugs : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE RELATIONSHIP BETWEEN ISCHEMIAINDUCED DECLINE OF MYOCARDIAL ATP CONTENT AND DISTURBANCE OF MYOCARDIAL SHORTENING : Coronary Circulation III : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Prevalence and Clinical Characteristics of Acute Myeloid Leukemia Associated with Disseminated Intravascular Coagulation
- Low burden of a JAK2-V617F mutated clone in monoclonal haematopoiesis in a Japanese woman with Budd-Chiari syndrome
- Sacroiliitis as an Initial Manifestation of Acute Myelogenous Leukemia
- Analysis of the Distribution of CAG Repeats and X-Chromosome Inactivation Status of HUMARA Gene in Healthy Female Subjects Using Improved Fluorescence-Based Assay
- Thiopurine Methyltransferase Genotype and Phenotype Status in Japanese Patients with Systemic Lupus Erythematosus(Biopharmacy)
- Comparison of the efficacy of an oral calcitriol pulse or intravenous 22-oxacalcitriol therapies in chronic hemodialysis patients
- Sulfite is Generated from PAPS by Activated Neutrophils
- Extremely high levels of C-reactive protein in patients with acute lupus serositis
- Inappropriate Discharges by Fourth Generation Implantable Cardioverter Defibrillators in Patients With Ventricular Arrhythmias
- Genotyping of Thiopurine Methyltransferase Using Pyrosequencing^(Biopharmacy)
- Acute Myeloid Leukemia Presenting as Subcutaneous and Epidural Granulocytic Sarcoma Inside and Outside of the Frontal Bone
- Recurrence of Acute Myelogenous Leukemia with the Same AML1/ETO Breakpoint as at Diagnosis after Complete Remission Lasting 15 Years : Analysis of Stored Bone Marrow Smears
- Acute Basophilic Leukemia Lacking Basophil-Specfic Antigens : The Importance of Cytokine Receptor Expression in Differential Diagnosis
- Role of cyclosporin A in remitting nephrotic syndrome in a Japanese patient infected with human immunodeficiency virus type 1
- Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders
- Maintenance and Characterization of an Epstein Barr Virus-infected CD56-negative T Cell Lymphoma
- Acquired Hemophilia A in a Patient with Systemic Lupus Erythematosus
- Difference in Ventricular Fibrillation interval between Structural Heart Disease and Brugada Syndrome : Role of Sotalol Treatmentand Defibrillation Threshold
- SUDDEN DEATH AFTER PROSTHETIC VALVE REPLACEMENT : Valvular Heart Disease : 46th Annual Scientific Meeting, Japanese Circulation Society
- VOLUME-OVERLOADED HEARTS AND THEIR HISTOLOGY : Valvular Heart Disease : 46th Annual Scientific Meeting, Japanese Circulation Society
- Expression of Thyroid Hormone Receptor Isoforms Down-regulated by Thyroid Hormone in Human Medulloblastoma Cells
- PROSTHETIC VALVE REPLACEMENT FOR ACQUIRED VALVULAR HEART DISEASE : Valvular heart disease : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- Activin A : Autocrine Regulator of Kidney Development and Repair
- Clinical characteristics of patients with inappropriate implantable cardioverter defibrillator(ICD)therapies : indication for dual-chamber ICD for sinus tachycardia
- Impaired Proliferation and Th1 Differentiation of CD4+ T Cells of SHPS-1 Mutant Mice
- Constitutive phosphorylation of a Rac GAP MgcRacGAP is implicated in v-Src-induced transformation of NIH3T3 cells
- A BASIC STUDY OF THE HANSSEN TECHNIQUE FOR EVALUATION OF SINGLE NEPHRON GLOMERULAR FILTRATION RATE
- Primary Bilateral Adrenal Diffuse Large B-cell Lymphoma Demonstrating Adrenal Failure
- Aplastic anemia associated with initiation of nizatidine therapy in a hemodialysis patient
- Herbal Medicine, Hachimi-jio-gan, and Its Component Cinnamomi Cortex Activate the Peroxisome Proliferator-activated Receptor Alpha in Renal Cells
- Sunitinib Induced Immune Thrombocytopenia
- Serum Thrombomodulin in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (MPO-ANCA)-Associated Vasculitis.
- Long-term inhibition of intimal hyperplasia using vascular photodynamic therapy in balloon-injured carotid arteries
- Photodynamic Treatment for Atherosclerotic Plaques of the Rabbit Abdominal Aorta by the Laparoscopical Approach Using a Pheophorbide Derivative
- OJ-051 A novel anticoagulation by selective removal of clotting factors(Antithrombofic Ttherapy (H) : OJ6)(Oral Presentation (Japanese))
- Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases
- A Population-based Study of Arterial Stiffness Index in Relation to Cardiovascular Risk Factors
- Differences in the JAK2 and MPL Mutation Status in the Cell Lineages of the bcr/abl-negative Chronic Myeloproliferative Neoplasm Subtypes
- Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol
- Efficacy and safety of tacrolimus for induction therapy in patients with active lupus nephritis
- Insulin-like growth factor binding protein-related protein 1 is expressed in rheumatoid synovium and regulates synovial fibroblast proliferation
- Study on the Structural Analysis of 3D Urban Space Model by Fractal Theory
- Upregulation of circulating IL-15 by treadmill running in healthy individuals : Is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?
- TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients
- Discrepancy in EBV-DNA load between peripheral blood and cerebrospinal fluid in a patient with isolated CNS post-transplant lymphoproliferative disorder
- A case report of a patient with rheumatoid arthritis complicated with Mycobacterium avium during tocilizumab treatment
- Long-term follow-up of EBV-positive lymphoproliferative disorders in a patient with systemic lupus erythematosus
- Hydronephrosis caused by a relapse of granulomatosis with polyangiitis (Wegener's)
- The Changes in Pattern of Myocardial Shortening by Reduction of Regional Coronary Blood Flow
- Age-Related Epstein-Barr Virus-Positive Lymphoproliferative Disorders of the Orbit and Maxillary Sinus : A Case Report
- Prognostic Importance of the Soluble Form of IL-2 Receptorα (sIL-2Rα) and its Relationship with Surface Expression of IL-2Rα (CD25) of Lymphoma Cells in Diffuse Large B-cell Lymphoma Treated with CHOP-like Regimen with or without Rituximab : A Retrospecti
- Renal disease in the elderly and the very elderly Japanese : analysis of the Japan Renal Biopsy Registry (J-RBR)
- Age-Related Epstein-Barr Virus-Positive Lymphoproliferative Disorders of the Orbit and Maxillary Sinus : A Case Report
- Development of IgG4-related fisease 10 years after chemotherapy for diffuse large B cell lymphoma and longstanding bronchial asthma