A BASIC STUDY OF THE HANSSEN TECHNIQUE FOR EVALUATION OF SINGLE NEPHRON GLOMERULAR FILTRATION RATE
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was mainly to examine some basic problems of the Hanssen technique for the evaluation of single nephron glomerular filtration rate (SNGFR). Firstly, experiments were performed using Wistar rats to determine the amount of C^<14>-ferrocyanide necessary to give sufficient C^<14> radioactivity in dissected nephrons. Using 200 μCi of C^<14>-ferrocyanide, the samples of dissected nephrons provided only twice as much as background. Hence, we chose the amount of 600 to 700 μCi of C^<14>-ferrocyanide for each rat in the later experiments, which yielded the radioactivity 5 to 6 times as much as background. Secondly, the homogeneity of intrarenal C^<14>-ferrocyanide distribution was tested. Five superficial (SUP) and juxtamedullary (JM) proximal tubules four different regions were dissected and the radioactivity of those nephrons was counted. The distribution of C^<14>-ferrocyanide in each piece was representative of the overal distribution. The summary of morphologic and clearance studies were as follows. The mean lengths of proximal tubules of 40 SUP nephrons, 5.3±0.2 mm, and 39 JM nephrons, 6.3±0.1 mm, were significantly different (P<0.01). The mean glomerular diameter of the JM nephrons, 110±2.7 μ, was significantly greater than that of the SUP nephrons, 95±3.1 μ (P<0.01). The mean SNGFR of 129 SUP nephrons, 23.4±4.2 nl/min/100 g Body Weight (BW), and that of 130 JM nephrons, 34.5±5.1 nl/min/100 g BW, were significantly different (P<0.01). The ratio of superficial/juxtamedullary nephron glomerular filtration rate (S/JM Ratio) was 0.85±0.02. We conclude that C^<14>-ferrocyanide is regularly distributed to the kidney and that it is necessary to infuse sufficient amount C^<14>-ferrocyanide in this technique.
- 社団法人日本循環器学会の論文
著者
-
GOTO Masashi
Department of General Medicine and Clinical Epidemiology, Kyoto University Graduate School of Medici
-
Wada Takao
Department Of Lnternal Medicine School Of Medicine Keio University
-
Wada Takao
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
-
Aizawa Koh
Department Of Lnternal Medicine School Of Medicine Keio University
-
Ino Yoshisuke
Department Of Lnternal Medicine School Of Medicine Keio University
-
Inamoto Hajime
Department Of Lnternal Medicine School Of Medicine Keio University
-
Inamoto Hajime
Department Of Internal Medicine School Of Medicine Keio University
-
Hayashi Junichi
Department of Internal Medicine, School of Medicine, Keio University
-
Wada Takao
Department Of Internal Medicine School Of Medicine Keio University
-
Kuroda Shigeomi
Department Of Lnternal Medicine School Of Medicine Keio University
-
Goto Masashi
Department Of General Medicine And Clinical Epidemiology Kyoto University Graduate School Of Medicin
-
Goto Masashi
Department Of Lnternal Medicine School Of Medicine Keio University
-
Wada Takao
Department Of Applied Electronics Daido Institute Of Technology
-
Hayashi Junichi
Department Of General Medicine School Of Medicine Kyorin University
-
Hayashi Junichi
Department Of Lnternal Medicine School Of Medicine Keio University
-
Goto Masashi
Department Of Comprehensive Care And Education Tenri Hospital
-
Hayashi Junichi
Department Of General Medicine Kyorin University School Of Medicine
-
Goto Masashi
Department of Applied Chemistry, Faculty of Engineering, Nagoya University
関連論文
- THE MECHANISM OF OLIGURIA IN ACUTE RENAL FAILURE: A FUNCTIONAL STUDY USING MICRODISSECTED NEPHRONS : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Chemical and Structural Characterization of Cu(In, Ga)Se_2/Mo Interface in Cu(In, Ga)Se_2 Solar Cells
- Surface Characterization of Chemically Treated Cu(In, Ga)Se_2 Thin Films
- BCG Vaccination and Tuberculosis in Japan
- Study Design, Statistical Method, and Level of Evidence in Japanese and American Clinical Journals
- STATISTICAL INFERENCES OF GROUPED DATA COMBINED WITH UNGROUPED DATA FROM THE POWER-NORMAL DISTRIBUTION
- INFERENCES BASED ON THE GROUPED OBSERVATIONS FROM THE BIVARIATE POWER-NORMAL DISTRIBUTION
- THE PROTECTION OF THE ISCHEMIC MYOCARDIUM WITH CoQ10 : Cardiovascular Drugs : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE RELATIONSHIP BETWEEN ISCHEMIAINDUCED DECLINE OF MYOCARDIAL ATP CONTENT AND DISTURBANCE OF MYOCARDIAL SHORTENING : Coronary Circulation III : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Effects of Anthracene Doping on Electrical and Light-Emitting Behavior of 8-Hydroxyquinoline-Aluminum-Based Electroluminescent Devices
- Preparation of Conductive and Transparent Thin Films by Argon Ion Beam Sputtering of Zinc Oxide in Atmosphere Containing Hydrogen
- High Energy Spectroscopy of Thin Films of Chalcopyrite Structure Cu-In-Se and Related Materials
- A Defect Model for Photoirradiated Semiconductors : Suppression of the Self-Compensation in II-VI Materials
- RENAL HEMODYNAMIC CHANGES ASSOCIATED WITH ANTIDIURETIC ACTIONS OF CHLORPROPAMIDE, CLOFIBRATE AND THIAZIDE IN DIABETES INSIPIDUS
- THE RELATION OF HYPERKALEMIA TO THE ELECTROCARDIOGRAPHIC CHANGES CAUSED BY ACIDEMIA
- The Renin-Angiotensin-Aldosterone System in Juvenile Hypertension : Part II
- Serum Angiotensinase Activity in Juvenile Hypertension
- 95) Statistical Studies of Juvenile Hypertension
- A Handy Detection Cell for End-Column Electrochemical Detection in Capillary Electrophoresis
- Four States of Surface-Stabilized Ferroelectric Liquid Crystal with Parallel Rubbing
- Effect of Surface Pretilt Angle on Optical Properties of Surface-Stabilized Ferroelectric Liquid Crystals
- Physical Vapor Deposition of Hexagonal and Tetragonal CuIn_5Se_8 Thin Films
- Microstructure of Cu(In,Ga)Se_2 Films Deposited in Low Se Vapor Pressure
- MoSe_2 layer formation at Cu(In, Ga)Se_2/Mo Interfaces in High Efficiency Cu(In_Ga_x)Se_2 Solar Cells
- Preparation of Device-Quality Cu(In, Ga)Se_2 Thin Films Deposited by Coevaporation with Composition Monitor
- Preparation of Ordered Vacancy Chalcopyrite-Type CuIn_3Se_5 Thin Films
- Inappropriate Discharges by Fourth Generation Implantable Cardioverter Defibrillators in Patients With Ventricular Arrhythmias
- Salazosulfapyridine-induced Angioimmunoblastic Lymphadenopathy
- Annealing Effect of High-T_c Superconducting Y(Ba_Sr_x)_2Cu_3O_ Ceramics
- Preparation Chalcopyrite-type Semiconductor Films by Sulfuration of Oxide Films
- Low Temperature Growth of Amorphous and Polycrystalline Silicon Films from a Modified Inductively Coupled Plasma
- Lower-Temperature Growth of Hydrogenated Amorphous Silicon Films from Inductively Coupled Silane Plasma
- Simple Direct Monitoring of SiH_3 Radical and Particulates in a Silane Plasma with Ultraviolet Transmission Spectroscopy
- Cross Section Measurements for Electron-Impact Dissociation of CHF_3 into Neutral and Ionic Radicals
- Difference in Ventricular Fibrillation interval between Structural Heart Disease and Brugada Syndrome : Role of Sotalol Treatmentand Defibrillation Threshold
- ESR Centers in Silicon Monoxide
- Annealing Effects of Paramagnetic Defects Introduced near Silicon Surface
- Influence of Deformation of Smectic Layer Structure on Dielectric Behavior of Ferroelectric Liquid Crystal
- Ferroelectric Liquid Crystal Mixtures Containing Chiral Pyranose Compounds for Response-Voltage Minimum Mode
- Layer Tilt Angle of Chevron Structure in Surface-Stabilized Ferroelectric Liquid Crystals
- Models of Molecular Orientation in Surface-Stabilized Ferroelectric Liquid Crystals with High-Pretilt Aligning Film
- Spin-polarized Tunneling in Ultrasmall Vertical Ferromagnetic Tunnel Junctions
- Excitation Frequency Effects on Stabilized Efficiency of Large-Area Amorphous Silicon Solar Cells Using Flexible Plastic Film Substrate
- Working Pressure Effects on Deposition of Large-Area Microcrystalline Silicon Films on Flexible Plastic Substrate at 130℃ : Semiconductors
- Excitation Frequency Effects on Large-Area Hydrogenated Amorphous Silicon Film Deposition Process Using Flexible Film Substrate : Semiconductors
- X-Ray Photoelectron Spectroscopy Study of a Self-Assembled Monolayer of Thiophene Thiol
- Fabrication of Nanometer-Scale Vertical Metal-Insulator-Metal Tunnel Junctions Using a Silicon-on-Insulator Substrate
- Fabrication of Nanometer-Scale Vertical MIM Tunnel Junctions Using a Double-Layered Inorganic Resist
- Preparation of Polythiphene Copolymer for Third Order Nonlinear Optics
- SiO_2/c-Si Bilayer Electron-Beam Resist Process for Nano-Fabrication
- SiO_2/Poly-Si Multilayered Electron Beam Resist Process for Fabrication of Ultrasmall Tunnel Junctions
- Annealing Behavior of Irradiation-Induced Damagein an AlGaAs/GaAs Heterostructure by Low-Ertergy Electron Beam
- Novel Switching with Gray Scale in Surface-Stabilized Ferroelectric Liquid Crystal Devices
- SUDDEN DEATH AFTER PROSTHETIC VALVE REPLACEMENT : Valvular Heart Disease : 46th Annual Scientific Meeting, Japanese Circulation Society
- VOLUME-OVERLOADED HEARTS AND THEIR HISTOLOGY : Valvular Heart Disease : 46th Annual Scientific Meeting, Japanese Circulation Society
- Effects of Hemoperfusion Plus High-Flux Hemodialysis in a Patient with Methotrexate Toxicity
- PROSTHETIC VALVE REPLACEMENT FOR ACQUIRED VALVULAR HEART DISEASE : Valvular heart disease : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- Electron Beam Doping by Superdiffusion in Unirradiated Regions (X
- E148Q/M694I Mutation in 3 Japanese Patients with Familial Mediterranean Fever
- Substitution Effect of Sr for Ba of High-T_c Superconducting YBa_2Cu_3O^ Ceramics
- Vapor Growth of AN-Doped ZnTe by the Closed-Tube Method
- Chemical Depth Profile of Thermal Oxide on GaSb Using XPS Method
- Electrical and Photoelectrical Characterization of n・Ga_xAl_Sb-p・GaSb Heterojunction
- Changes of DLTS Spectrum in n-Si due to 7-10 MeV Electron-Irradiation
- Vapor Growth of Te-Doped Ga_xAl_Sb on GaSb
- Vapor-Phase Growth of Te-Doped GaSb
- Vapor Phase Growth of Ga_xAl_1__xSb
- Low Temperature Vapor Growth of Zinc Telluride
- Optical Characterization of GaSb-Based Ternary and Quaternary Alloys Grown by Liquid-Phase Epitaxy at Low Temperatures
- Photoluminescence Study of Al_xGa_Sb Grown by Liquid-Phase Epitaxy
- X-Rat Photoelectron Spectra of an Electron-Beam Oxide Layer on GaSb
- Direct Comparison of Quantized Hall Resistance between Si-MOSFET and GaAs/AlGaAs Heterostructure Devices on the Same Sample Holder
- Clinical characteristics of patients with inappropriate implantable cardioverter defibrillator(ICD)therapies : indication for dual-chamber ICD for sinus tachycardia
- ESCAPE FROM SODIUM AND POTASSIUM RETAINING ACTIONS OF ASPIRIN-LIKE DRUGS USED IN A PATIENT WITH BARTTER'S SYNDROME
- Effects of Electron Irradiation on Two-Dimensional Electron Gas in AlGaAs/GaAs Heterostructure
- The States of Surface-Stabilized Ferroelectric Liquid Crystal with High-Pretilt Aligning Film
- A BASIC STUDY OF THE HANSSEN TECHNIQUE FOR EVALUATION OF SINGLE NEPHRON GLOMERULAR FILTRATION RATE
- Electrochromic Behavior of Amorphous Copperphthalocyanine Thin Films
- Two-Dimensional Electron Gas in an n^+-GaAs/Undoped AlGaAs/Undoped GaAs SIS Structure
- Optimum B^+ Dose in S/D Regions to Improve Schottky p-Channel MOSFET Characteristics
- Improvement of Schottky MOSFET Characteristics by B^+ Implantation in Active Region
- Calculation of Bond Lengths in Si_Ge_x Alloys Based on the Valence-Force-Field Model
- Optical Absorption and Modification of Band Edges in Irradiated GaP
- Serum Thrombomodulin in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (MPO-ANCA)-Associated Vasculitis.
- Long-term inhibition of intimal hyperplasia using vascular photodynamic therapy in balloon-injured carotid arteries
- Photodynamic Treatment for Atherosclerotic Plaques of the Rabbit Abdominal Aorta by the Laparoscopical Approach Using a Pheophorbide Derivative
- OJ-051 A novel anticoagulation by selective removal of clotting factors(Antithrombofic Ttherapy (H) : OJ6)(Oral Presentation (Japanese))
- Study Design, Statistical Method, and Level of Evidence in Japanese and American Clinical Journals
- Estimation of Body Water and Salt Contents from Plasma Sodium, Protein Concentrations, and Hematocrit
- Effect of iron as a new type of phosphate binder in hemodialysis patients
- Heteroepitaxial Growth of ZnTe on GaSb
- Negative Resistance Due to Impact Ionization in Irradiated Germanium
- Decrease of Built-in Voltage in Tunnel Diodes Caused by Irradiation
- Typical Electron Beam Doping(Superdiffusion)of Impurity Atoms in Damage-Free Regions of Semiconductors by the Kick-Out Mechanism
- STATISTICAL EVALUATION OF UMBRELLA DOSE-RESPONSE RELATIONSHIPS(Categorical Data Analysis)
- Distribution of Radiation-Damage Rate with Depth in Silicon Bombarded with the High Energy Electrons
- Native Defects in III-V Ternary Alloy Semiconductors Grown from Liquid-Solutions
- Electron Beam Doping (Superdiffusion) in Damage-Free Regions of Semiconductors by the Kick-Out Mechanism (Secondary-Ion Mass Spectrometer and Photoluminescence Measurements)
- Energy Spectra of Displaced Atoms in High-Energy Electron-Irradiated Si: Views on Electron Beam Doping and Damage Factor
- The Changes in Pattern of Myocardial Shortening by Reduction of Regional Coronary Blood Flow