RENAL HEMODYNAMIC CHANGES ASSOCIATED WITH ANTIDIURETIC ACTIONS OF CHLORPROPAMIDE, CLOFIBRATE AND THIAZIDE IN DIABETES INSIPIDUS

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概要

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• A careful study was performed in two patients of idiopathic diabetes insipidus (DI) to assess the role of renal hemodynamic changes in antidiuresis induced by several agents commonly used for the treatment of DI patients.' In one patient, every one of chlorpropamide, clofibrate and thiazide caused a decrease in effective renal plasma flow (ERPF) by about 20% in association with a decrease in urine volume by 40-50%. No significant decrease in GFR was seen in the patient. In the other patient, every one of the above drugs caused a decrease not only in ERPF (by 25-40%) but also in GFR (by 25-35%) in association with a more remarkable decrease in urine volume (by 60-70%). These renal hemodynamic changes resembled those induced by the administration of exogenous vasopressin. Thus renal hemodynamic changes should be taken into consideration when one studies the mechanism of antidiuresis induced by the drugs mentioned above.

• 社団法人日本循環器学会の論文
• 1973-11-20

著者

• Yoshida Ryoji

  Dept. of Internal Medicine, School of Medicine, Keio University

• Kitamoto Kiyoshi

  Dept. of Internal Medicine, School of Medicine, Keio University

• Kato Eiichi

  Dept. of Internal Medicine, School of Medicine, Keio University

• Nomoto Yasuo

  The Department Of Internal Medicine School Of Medicine. Keio University

• Yoshida Ryoji

  Dept. Of Internal Medicine School Of Medicine Keio University

• Wada Takao

  Department Of Lnternal Medicine School Of Medicine Keio University

• Asano Seiichi

  Dept. Of Internal Medicine School Of Medicine Keio University

• Kato Eiichi

  Department Of Internal Medicineicine Keio University School Of Medicine

• Yamanouchi Makoto

  The Department Of Internal Medicine School Of Medicine. Keio University

• ASANO SEIICHI

  The Department of Internal Medicine, Keio University School of Medicine

• Wada Takao

  Department Of Internal Medicine School Of Medicine Keio University

• Kato Eiichi

  Dept. Of Intern. Med. Keio Univ. Sch. Of Med.

• WADA TAKAO

  The Department of Internal Medicine, School of Medicine. Keio University

• KITAMOTO KIYOSHI

  The Department of Internal Medicine, School of Medicine. Keio University

• YOSHIDA RYOJI

  The Department of Internal Medicine, School of Medicine. Keio University

• YAMAUCHI MAKOTO

  The Department of Internal Medicine, School of Medicine. Keio University

• KATO EIICHI

  The Department of Internal Medicine, School of Medicine. Keio University

• Kitamoto Kiyoshi

  Dept. Of Internal Medicine School Of Medicine Keio University

• Kato Eiichi

  Dept. Of Intern. Med. School Of Med. Keio Univ.

• Asano Seiichi

  Dept. Of Intern. Med. School Of Med. Keio Univ.

• Kato Eiichi

  Department Of Internal Medicine School Of Medicine Keio University

• Kato Eiichi

  The Department Of Internal Medicine School Of Medicine Keio University

• Yamauchi Makoto

  The Department Of Internal Medicine School Of Medicine. Keio University

• Wada Takao

  Department of Internal Medicine, School of Medicine, Keio University

• KATO Eiichi

  Department of Internal Medicine, Keio University School of Medicine

• 加藤 暎一

  慶応義塾大学内科

• 加藤 暎一

  慶応義塾大学医学部内科

• KATO EIICHI

  Department of Internal Medicine, School of Medicine, Keio University

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