STUDIES ON WATER AND ELECTROLYTE-REGULATING HORMONES:I. PLASMA ANTIDIURETIC ACTIVITY AND URINARY SODIUM-RETAINING ACTIVITY IN PATIENTS WITH EDEMATOUS DISEASES

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概要

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• Both antidiuretic activity of the plasma and sodium-retaining activity of the urine from patients with edmatous diseases were assayed. The results obtained are as follows;Both plsma antidiuretic activity and urinary sodium-retaining activity were increased in patients with so-called secondary hyperaldosteronism.Some correlation between urinary sodium-retaining activity and sodium output was found in the limited groups of patients assayed, but no correlation was observed in patients with cirrhosis of the liver.In bioassay of crude extracts of urine from some cases of non-edematous patients, the negative value, i.e. sodium-excreting activities were obtained.On the basis of our findings, the roles of ADH and aldosterone in the pathogenesis of edema formation and the possibility of the presence of sodium-excreting hormones in human body were discussed.

• The Keio Journal of Medicineの論文

著者

• AIZAWA Toyozo

  Department of Internal Medicine Keio University

• ASANO SEIICHI

  Department of Internal Medicine, School of Medicine, Keio University

• Hagiwara Takashi

  Department Of Biological Science And Technology Tokai University

• Kato Eiichi

  Department Of Internal Medicine School Of Medicine Keio University

• HAGIWARA TAKASHI

  Department of Internal Medicine, School of Medicine Keio University

• HIRATA KIYOFUMI

  Department of Internal Medicine, School of Medicine Keio University

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