THE RELATION OF HYPERKALEMIA TO THE ELECTROCARDIOGRAPHIC CHANGES CAUSED BY ACIDEMIA

概要

論文の詳細を見る
Acidemia was induced in normal dogs by CO_2 administration. Plasma electrolyte concentration showed a rise of sodium and potassium and a fall of chloride. Electrocardiograms recorded at the same time showed T-wave changes which resembled those induced by KCl infusion in the same animals. Besides, QTC tended to decrease at that time to the same degree as in KCl infusion. However, the degree of hyperkalemia induced by the acidemia was much less remarkable than those by KCI infusion when both conditions were compared on the same level of T-wave changes. When the acidemia was suppressed with a solution of Tris-buffer (THAM) containing potassium, T-wave changes were also suppressed in spite of the rise of plasma potassium level. These findings suggest that 'some factors other than hyperkalemia caused the above electrocardiographic changes. Judging from the plasma electrolyte changes seen in the acidemia and from another observation that hypertonic NaCl or NaHCO_3 also causes similar electrocardiographic changes, it is concluded that the changes in gradients across cell membranes of multiple electrolytes, including potassium, sodium, hydrogen ion and so forth, are responsible for the electrocardiographic changes seen in acidemia.
社団法人日本循環器学会の論文
1973-11-20