Hypertension Induced by Adrenocortical Dysfunction : Hypertension in 17α-Hydroxylase Deficiency and Metopirone-Induced Hypertension : VII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

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Hypertension in 17α-hydroxylase deficiency as studied by comparing it with hypertension in Cushing syndrome or that in primary aldosteronism. Furthermore, the role of endogenous increases of ACTH, deoxycorticosterone, and 18α-hydroxy-deoxycorticosterone upon blood pressure was studied in rats by administerating metopirone. Hypertension in 17α-hydroxylase deficiency was considered to be more similar to that in primary aldosteronism from the studies on renin components, pressor responses to angiotensin II and norepinephrine, and renin responses to stimulations. Plasma catecholamines were slightly decreased in 17α-hydroxylase deficiency. The hypertension was alleviated by the administeration of dexamethasone in 2 of 3 patients with 17α-hydroxylase deficiency. However, in the remaining one who had an accelerated hypertension and normal renin, the hypertension was not alleviated by dexamethasone. In the animal studies, hypertension induced by metopirone was accelerated by salt loading or uni-lateral nephrectomy plus salt loading. in those rats, plasma ACTH, and deoxycorticosterone were markedly increased.
社団法人日本循環器学会の論文
1978-06-20