Metoclopramide in the diagnosis of pheochromocytoma.
スポンサーリンク
概要
- 論文の詳細を見る
Cardiovascular and plasma catecholamine responses to metoclopramide (MCP), a dopamine antagonist, were examined in 5 patients with pheochromocytoma, 12 patients with essential hypertension (EHT) and 9 normotensive (NT) subjects who displayed symptoms suggestive of pheochromocytoma on a constant daily intake of 100mEq sodium and 80mEq potassium. Significant pressor responses to intravenous doses of 5mg of MCP, which produced no serious pressor episodes and no other undesirable side effects, were found only in the patients with pheochromocytoma, in contrast to the subjects with EHT and NT who tended to display slight depressor responses. After curative surgery for pheochromocytoma, the MCP-induced pressor effects returned to normal. Furthermore, the enhanced pressor effects of MCP in the patients with pheochromocytoma were associated with increased plasma norepinephrine (NE) concentrations. However, the plasma epinephrine (E) concentrations remained unchanged after the MCP injection. Thus, this dose of MCP appears to be a more suitable vasopressor provocative agent in the pharmacological diagnosis of pheochromocytoma compared to currently used agents.
- International Heart Journal刊行会の論文
著者
-
Saruta Takao
Department Of Clinical Pharmacology Jichi Medical School
-
Kondo Kazuoki
Department Of Clinical Pharmacology Jichi Medical Schcol
-
Suzuki Hiromichi
Department Of Applied Physics Faculty Of Science Fukuoka University
-
Kawabe Hiroshi
Department Of Aeronautics And Space Engineering Graduate School Of Engineering Tohoko University
-
KONDO Kazuoki
Department of Clinical Pharmacology, Jichi Medical School
-
ITAYA Yoshiaki
Department of Internal Medicine, Keio University School of Medicine
関連論文
- The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
- A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension : the REZALT study
- Effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease : subanalysis of the CASE-J Study
- Effects of Cardiac Complications on Cardiovascular Events in Japanese High-Risk Hypertensive Patients : Subanalysis of the CASE-J Trial
- Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications : a sub-analysis of the CASE-J trial
- Role of diabetes and obesity in outcomes of the candesartan antihypertensive survival evaluation in Japan (CASE-J) trial
- 1 Which Risk Factor Has an Adverse Effect on Coronary Events in Japanese High-risk Hypertensive Patients? : a Subanalysis of CASE-J(Comprehensive Risk Management for Prevention of Coronary Artery Disease,Symposium 16 (SY-16) (H),The 73rd Annual Scientific
- Effect of heart rate on the risk of developing metabolic syndrome
- Decreased body mass index as an independent risk factor for developing chronic kidney disease
- PJ-131 Cardiometabolic Effects Induced by Lower and Extremely Lower Doses of Diuretics in Uncontrolled Hypertension Treated with Angiotensin II Receptor Blockers(Hypertension, clinical(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of
- Association Between Heart Rate and Multiple Risk Factor Syndrome : Cross-Sectional Analysis of a Screened Cohort in Okinawa, Japan
- Higher Heart Rate Predicts the Risk of Developing Hypertension in a Normotensive Screened Cohort
- Metabolic Syndrome and Risk of Developing Chronic Kidney Disease in Japanese Adults
- Response to : The Contribution of Nutrition to the Protective Value of High Plasma Aldosterone Concentrations in Hemodialysis Patients
- 4 On-going Japanese Clinical Trials for Hypertension II : Seeking for More Effective Pharmacological Treatment(ESC-JCS Joint Symposium (ESC-JCS Joint Symposium) (H) Evidence-Based Medical Treatment of Hypertension,Special Program,The 72nd Annual Scientifi
- FRS-091 Impairment of Ubiquitin-Proteasome System Caused by a Missense MYBPC3 Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Sessi
- Association of Genetic Polymorphisms of Endothelin-Converting Enzyme-1 Gene with Hypertension in a Japanese Population and Rare Missense Mutation in Preproendothelin-1 in Japanese Hypertensives
- Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese
- Impact of Left Ventricular Hypertrophy on the Time-Course of Renal Function in Hypertensive Patients : A Subanalysis of the CASE-J Trial
- Genetic Variations of CYP2C9 in 724 Japanese Individuals and Their Impact on the Antihypertensive Effects of Losartan
- Associations of Hypertension and Its Complications with Variations in the Xanthine Dehydrogenase Gene
- The Optimal Target Blood Pressure for Antihypertensive Treatment in Japanese Elderly Patients with High-Risk Hypertension : A Subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial
- Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients : Rationale, Design, and Methods
- Influence of Hypertension on the Incidence of Cardiovascular Disease in Two Rural Communities in Japan : The Tanno-Soubetsu Study
- Adult T-cell Leukemia with Hypercalcemia-induced Metastatic Calcification in the Lungs Due to Production of Parathyroid Hormone-related Protein
- Valsartan in Elderly Isolated Systolic Hypertension (VALISH) Study : Rationale and Design
- Genetic Polymorphisms of L-Type Calcium Channel α1c and α1D Subunit Genes are Associated With Sensitivity to the Antihypertensive Effects of L-Type Dihydropyridine Calcium-Channel Blockers
- Spironolactone in Combination with Cilazapril Ameliorates Proteinuria and Renal Interstitial Fibrosis in Rats with Anti-Thy-1 Irreversible Nephritis
- Impaired Nitric Oxide-Independent Dilation of Renal Afferent Arterioles in Spontaneously Hypertensive Rats
- PE-213 Diabetes and Chronic Kidney Disease Contribute to Inadequate Blood Pressure Control in Hypertension Treated with Angiotensin Receptor Blocker/Diuretics(PE036,Hypertension, Clinical 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting o
- Rationale, study design and implementation of the COLM study : the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients
- Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats
- Monosynaptic Excitatory Connection from the Rostral Ventrolateral Medulla to Sympathetic Preganglionic Neurons Revealed by Simultaneous Recordings
- The Mechanism of Estrogen Hypertension
- How to manage refractory hypertension
- A Functional Thyrotropin-and Growth Hormone-Secreting Pituitary Adenoma with a Ultrastructurally Monomorphic Feature:A Case Study
- PJ-687 Utilization of Echocardiography in Stroke Care Unit of Tokushima University Hospital(PJ115,Thromboembolism/Antithrombotic Therapy/Thrombolysis (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-579 Plasma Concentration of Pentraxin 3 is a Useful Marker for Monitoring the Anti-plaque Effect of Telmisartan(PJ097,Cardiovascular Pharmacology (Clinical) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- PJ-391 Pentraxin 3, a Novel Inflammatory Marker, Predicts Left Ventricular Remodeling in Patients with Acute Myocardial Infarction(PJ066,ACS/AMI (Basic) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- PE-553 Prediction of Cardiac Response to Preload Augmentation by Dual Doppler Echocardiography and Left Arial Volume Auto Tracking System(PE093,Echo/Doppler (Others) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulati
- PE-494 Synthetic Prostacycline Agonist, ONO-1301, Ameliorates Left Ventricular Dysfunction and Cardiac Fibrosis in Cardiomyopathic Hamsters(PE083,Cardiovascular Pharmacology (Basic), Cost-health Care System/DPC/Laws (H),Poster Session (English),The 73rd A
- PE-381 Local Persistent Hypercoagulability after Drug-Eluting Stent Implantation : Sirolimus-Eluting Stent vs. Paclitaxel-Eluting Stent(PE064,Coronary Revascularization, PCI (DES) 6 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the
- PE-347 Early Detection of Myocardial Damage in Female Carriers of Duchenne Muscular Dystrophy : the Utility of Cardiac Magnetic Resonance(PE058,Cardiomyopathy/Hypertrophy (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The
- PE-342 Angiotensin-II Receptor Blocker Prevents the Deterioration of Left Ventricular Geometry and Diastolic Function in Hypertrophic Cardiomyopathy(PE058,Cardiomyopathy/Hypertrophy (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scientific Meet
- PE-110 Postsystolic Shortening is Superior to Peak Systolic Strain on the Prediction of Ischemia in Normal Wall Motion Segments(PE019,Echo/Doppler (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
- DPJ-022 Elevation of Left Ventricular End-diastolic Pressure Enhances Mismatch between Mitral Inflow and Annular Motion(DPJ04,Heart Failure (Diagnosis) (M),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- DPE-042 Plasma Aldosterone Concentration is Associated with Cognitive Impairement in Patients with Hypertension(DPE07,Hypertension, Clinical (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-001 Long-Term Local Inflammatory Response after Coronary Artery Stenting : BMS vs. SES vs. PES(OJ01,Coronary Revascularization, PCI (DES) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-366 Bosentan, an Endothelin Receptor Antagonist, Exerts Protective Actions against Systemic Sclerosis-related Peripheral Circulation Insufficiency(OE62,Peripheral Circulation/Vascular Disease (Therapy) (H),Oral Presentation (English),The 73rd Annual Sc
- OE-213 Pitavastatin Exerts LDL Cholesterol Reduction-independent Protective Action for Cardiac and Renal Function in Patients with Dyslipidemia(OE36,Atherosclerosis (Clinical/Treatment) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting
- OE-179 Effect of Ghrelin on Autonomic Activity in Healthy Volunteers(OE31,Cardiovascular Pharmacology (Basic) (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- IgG1 Is the Dominant Subclass of Antibody against Glutamic Acid Decarboxylase among Type 1 Diabetes in Japanese
- Autoantibody against IA-2 Improves the Test Sensitivity for Insulin-Dependent Diabetes Mellitus in Japanese Patients of Child Onset
- Glutamic Acid Decarboxylase65 (GAD65) Antibodies and Insulin Auto-Antibodies in Japanese Patients with Non-Insulin-Dependent Diabetes Mellitus
- Antibodies to the 37,000-Mr Tryptic Fragment of Islet Antigen were Detected in Japanese Insulin-Dependent Diabetes Mellitus Patients
- Nitric Oxide Is lmportant for Mouse Beta-Cell Line Killing by Peritoneal Exudate Cells Obtained from Cyclophosphamide Treated Non-Obese Diabeitc Mice
- -433- CARDIOVASCULAR EFFECTS OF INTRAVENOUS AND INTRACORONARY ADMINISTRATION OF ATRIAL NATRIURETIC PEPTIDE IN HALOTHANE ANESTHETIZED DOGS
- Prevention and regression of hypertension : role of renal microvascular protection
- Developmental Activity of the Renin-Angiotensin System during the "Critical Period" Modulates Later L-NAME-Induced Hypertension and Renal Injury
- Comparison of Health Costs Associated with Treatment of Hypertension with a Calcium Channel Blocker and Angiotensin-Converting Enzyme Inhibitor in the United States and Japan
- Glomerulonephritis with microtubular deposits associated with cryoglobulinemia and chronic active hepatitis
- Effects of AT1 Receptor Antagonist on Proteoglycan Gene Expression in Hypertensive Rats
- Plasma Aldosterone Concentrations Are Not Related to the Degree of Angiotensin-Converting Enzyme Inhibition in Essential Hypertensive Patients
- Different role of angiotensin II type 1 and type 2 receptors in renin release by interaction of angiotensin II and renal sympathetic nerve
- Modulation of Angiotensin II Type 1 Receptor mRNA Expression in Human Blood Cells: Comparison of Platelets and Mononuclear Leucocytes
- -1241-EFFECTS OF VASOACTIVE SUBSTANCES ON COLLAGEN SYNTHESIS IN CULTURED VASCULAR SMOOTH MUSCLE CELLS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -P111-EFFECTS OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) ON SYSTEMIC AND RENAL HEMODYNAMICS IN CONSCIOUS DOGS : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PE-209 Pitavastatin Excretes eNOS-independent Protective Action against Angiotensin II-induced Atrial Remodeling through Attenuating Rac1-madiated Oxidative Stress(PE035,Cardiovascular Pharmacology (Basic) (H),Poster Session (English),The 73rd Annual Scie
- Hyperglycemia Decreases Dehydroepiandrosterone in Japanese Male with Impaired Glucose Tolerance and Low Insulin Response
- A 35-year-old Man with Cerebral Hemorrhage and Pheochromocytoma : The Second Brain-dead Organ Donor in Japan
- Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design
- Effects of Leptin Receptor Gene 3'-untranslated Region Polymorphism on Metabolic Profiles in Young Japanese Men
- Insulin Resistance and Hypertension : Seven-Year Follow-Up Study in Middle-Aged Japanese Men (the KEIO Study)
- Effects of Body Weight Control on Changes in Blood Pressure : Three-Year Follow-Up Study in Young Japanese Individuals
- Participation in School Sports Clubs and Related Effects on Cardiovascular Risk Factors in Young Males
- Sexual Differences in Relationships between Birth Weight or Current Body Weight and Blood Pressure or Cholesterol in Young Japanese Students
- Insulin Resistance Syndrome in Adolescents and Adults
- OE-015 Peripheral Blood Level of Matrix Metalloprotease-9 is Elevated in Patients with Acute Aortic Dissection(Emergency care-1 (H) OE3,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Candesartan and Amlodipine Reduced the High Linearity and Increased the Low Linearity of Cardiovascular Regulation in Spontaneously Hypertensive Rats
- Candesartan Can Reduce Cardiovascular Events by Decreasing Sympathetic Nerve Activity and Plasma Aldosterone
- Difference in the Incidence of Cough Induced by Angiotensin Converting Enzyme Inhibitors: a Comparative Study Using Imidapril Hydrochloride and Enalapril Maleate
- Role of Asymmetrical Dimethylarginine in Renal Microvascular Endothelial Dysfunction in Chronic Renal Failure with Hypertension
- Distinct Modulation of Superficial and Juxtamedullary Arterioles by Prostaglandin in Vivo
- Tolerability and Safety of a Calcium Channel Blocker in Comparison with a Diuretic in the Treatment of Elderly Ptients with Hypertension : Secondary Analysis of the NICS-EH
- Beneficial Effects of Pioglitazone on Left Ventricular Hypertrophy in Genetically Hypertensive Rats
- Pioglitazone, a Thiazolidinedione Derivative, Attenuates Left Ventricular Hypertrophy and Fibrosis in Salt-Sensitive Hypertension
- Azelnidipine Attenuates Cardiovascular and Sympathetic Responses to Air-Jet Stress in Genetically Hypertensive Rats
- RENIN RELEASE AND THE JUXTAGLOMERULAR APPARATUS IN CHRONIC RENAL FAILURE DUE TO GLOMERULONEPHRITIS
- Effects of Angiotensin III (DES-1-Asp-Angiotensin II) and Angiotensin III Analogue (DES-1-Asp-8-Ile-Angiotensin II) upon Adrenal Steroidogenesis and Blood Pressure
- Angiotensinase Activity Using Human Crude Angiotensin
- OE-141 Cardio-cerebral and Cardio-renal Complications in High-risk Hypertensive Patients with Cardiac Risks Based on the Results of CASE-J Trial(Hypertension, clinical(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Ci
- FRS-003 Prognostic Value of Left Ventricular Hypertrophy and Changes in Left Ventricular Mass in Hypertensive Patients : An analysis of CASE-J Trial(New Clinical Aspects for Hypertension(H),Featured Research Session,The 72nd Annual Scientific Meeting of t
- 1 To Make the Best Use of Japanese Evidences to Future Guidelines : From the Results and Experiences of CASE-J Trial(Symposium 18 (SY-18) (H) How can we Make the Best Use of Japanese Evidences for Future Guidelines,Special Program,The 72nd Annual Scientif
- Primary Malignant Hepatic Pheochromocytoma with Negative Adrenal Scintigraphy
- Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats : Studies in the isolated perfused hydronephrotic kidney
- Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury : Role of Rho-Kinase in the Development of Renal Injury
- Pathophysiological Significance of T-type Ca^ Channels : Role of T-type Ca^ Channels in Renal Microcirculation
- Pioglitazone Lowers Systemic Asymmetric Dimethylarginine by Inducing Dimethylarginine Dimethylaminohydrolase in Rats
- PJ-147 ADMA and DDAH as Determinants of Coronary Endothelial Dysfunction in Early-stage CRF(Endothelium/NO 2 (H) : PJ25)(Poster Session (Japanese))
- Antihypertensive Efficacy and Safety of Fixed-Dose Combination Therapy with Losartan plus Hydrochlorothiazide in Japanese Patients with Essential Hypertension