Pathophysiological Significance of T-type Ca^<2+> Channels : Role of T-type Ca^<2+> Channels in Renal Microcirculation
スポンサーリンク
概要
- 論文の詳細を見る
Since conventional Ca2+ antagonists, with predominant blockade of L-type voltage-dependent Ca2+ channels, elicit preferential dilation of afferent arterioles, they might ostensibly aggravate glomerular hypertension. Recently, novel Ca2+ antagonists, with inhibitory action on L-/T-type Ca2+ channels, have been reported to dilate both afferent and efferent arterioles. The present review attempted to characterize the renal action of these Ca2+ antagonists and evaluated the consequences following the treatment with these agents. In contrast to conventional Ca2+ antagonists (e.g., nifedipine), novel antagonists (e.g., benidipine, efonidipine) potently dilated afferent and efferent arterioles; their action on efferent arterioles appeared to be mediated by the T-type Ca2+ channel blockade, probably through the inhibition of the intracellular Ca 2+ release. The comparison of the anti-proteinuric action in subtotally nephrectomized rats showed that efonidipine exerted more prominent action than nifedipine. Furthermore, Ca2+ antagonists with T-type Ca2+ inhibitory action inhibited renin/aldosterone release and proinflammatory process. Finally, patients with chronic renal disease given a 48-week efonidipine treatment showed reduced proteinuria, and this effect was seen even when mean arterial blood pressure failed to become less than 100 mmHg. Collectively, T-type Ca2+ channel blockade provides beneficial action in renal injury. Various mechanisms serve to protect against renal injury, including systemic/glomerular hemodynamic action and non-hemodynamic mechanisms.
- 社団法人 日本薬理学会の論文
- 2005-11-20
著者
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林田 孝平
国立循環器病センター放射線診療部
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HAYASHI Koichi
Keio University
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SARUTA Takao
Department of Internal Medicine, School of Medicine, Keio University
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HAYASHI Koichi
Department of Internal Medicine, Keio University School of Medicine
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Hayashi Koichi
慶応義塾大学 医学部内科学教室
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Hayashi Koichi
Department Of Internal Medicine Keio University School Of Medicine
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KITAOKA Hirofumi
Ohasama Hospital
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Kumagai Hiroo
Department Of Nephrology National Defense Medical College
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Saruta Takao
Dept. Of Internal Medicine Keio University School Of Medicine
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HASHIMOTO Katsuji
Osaka National Hospital
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Homma Koichiro
Department of Internal Medicine, Keio University School of Medicne
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Wakino Shu
Department of Emergency Medicine, Keio University
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Saruta Takao
Department Of Clinical Pharmacology Jichi Medical School
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Wakino Shu
Department Of Internal Medicine School Of Medicine Keio University
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Wakino Shu
Department Of Emergency Medicine Keio University
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林田 孝平
Keio University
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SUGANO Naoki
Department of Internal Medicine, School of Medicine, Keio University
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Homma Koichiro
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
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Sugano Naoki
Department Of Internal Medicine School Of Medicine Keio University
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Kurihara Hiroki
Department Of Physiological Chemistry And Metabolism Graduate School Of Medicine University Of Tokyo
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Homma Koichiro
Department Of Internal Medicine Keio University School Of Medicine
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Hayashi Koichi
Department Of Dermatology Shinshu University School Of Medicine
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Hayashi Koichi
Japanese Red Cross Hiroshima College Of Nursing
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