Effects of Angiotensin III (DES-1-Asp-Angiotensin II) and Angiotensin III Analogue (DES-1-Asp-8-Ile-Angiotensin II) upon Adrenal Steroidogenesis and Blood Pressure
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概要
- 論文の詳細を見る
Effects of angiotensin III and angiotensin III analogue upon adrenal steroidogenesis and blood pressure were studied in rats, rabbits and a man. Pressor effect of angiotensin III was about one fifth of that of angiotensin II in all the species. Degradation rate of pressor effect of angiotensin III in plasma was more rapid than that of angiotensin II. Different from the effects of angiotensin III upon blood pressure, its effect upon aldosterone was similar to that of angiotensin II. The effect of angiotensin III upon other adrenal steroids, such as DOC and cortisol, however, seemed to be slightly less than that of angiotensin II. Angiotensin III produced an additive effect to that of ACTH, but it didn't produce and additive effect to that of angiotensin II. Angiotensin III analogue, itself, stimulated adrenal steroidogenesis, but it inhibited the effects of angiotensin III and angiotensin II upon aldosterone. Effects of ACTH upon plasma DOC and cortisol were not inhibited by angiotensin III analogue, but the effect of ACTH upon aldosterone was blunted slightly.
- 社団法人日本循環器学会の論文
- 1977-09-20
著者
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SARUTA Takao
Department of Internal Medicine, School of Medicine, Keio University
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Ozawa Yukio
Department Of Internal Medicineicine Keio University School Of Medicine
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Ozawa Yukio
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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Ozawa Yukio
Dept. Of Intern. Med. School Of Med. Keio Univ
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Kato Eiichi
Department Of Internal Medicineicine Keio University School Of Medicine
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Ozawa Yukio
The Department Of Internal Medicine Keio University School Of Medicine
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Saito Ikuo
Department Of Internal Medicineicine Keio University School Of Medicine
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Saruta Takao
Department Of Clinical Pharmacology Jichi Medical School
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KONISHI Konosuke
Department of Medicine, School of Medicine, Keio University
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Kato Eiichi
Dept. Of Intern. Med. Keio Univ. Sch. Of Med.
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NAKAMURA Ryuichi
Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University
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MATSUKI SHUN
Departments of Internal Medicine,School of Medicine, Keio University
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KITAJIMA WAICHI
Department of Internal Medicineicine,Keio University School of Medicine
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OKA MASATUGU
Department of Internal Medicineicine,Keio University School of Medicine
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NITTA MASASHI
Department of Internal Medicine, Keio University School of Medicine
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OKA MASATSUGU
Department of Internal Medicine, Keio University School of Medicine
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Oka Masatugu
Department Of Internal Medicineicine Keio University School Of Medicine
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Matsuki Shun
Department Of Internal Medicineicine Keio University School Of Medicine
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Matsuki Shun
Department Of Internal Medicine Keio University
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Nitta Masashi
Department Of Internal Medicine Keio University School Of Medicine
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Saito Ikuo
Department Of Biotechnology Graduate School Of Engineering Nagoya University
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Kato Eiichi
Dept. Of Intern. Med. School Of Med. Keio Univ.
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Kitajima Waichi
Department Of Internal Medicineicine Keio University School Of Medicine
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Matuki Susumu
Dept. Of Intern. Med. School Of Med. Keio University Tokyo
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Nakamura Ryuichi
Department Of Internal Medicine School Of Medicine Keio University
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Nakamura Ryuichi
Department Of Chemical Engineering Faculty Of Engineering Tokyo Institute Of Technology
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Konishi Konosuke
Department Of Internal Medicineicine Keio University School Of Medicine
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Konishi Konosuke
Department Of Internal Medicine School Of Medicine Keio University
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Kato Eiichi
Department Of Internal Medicine School Of Medicine Keio University
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Kato Eiichi
The Department Of Internal Medicine School Of Medicine Keio University
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Nakamura Ryuichi
Department Of Internal Medicine Keio University School Of Medicine
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Konishi Konosuke
Department Of Internal Medicine Keio University School Of Medicine
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MATSUKI SHUN
Department of Internal Medicine , Keio University
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KATO Eiichi
Department of Internal Medicine, Keio University School of Medicine
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加藤 暎一
慶応義塾大学内科
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加藤 暎一
慶応義塾大学医学部内科
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KATO EIICHI
Department of Internal Medicine, School of Medicine, Keio University
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