Effects of angiotensin I converting enzyme inhibitors on the renal excretory function, hemodynamics and renin release in isolated perfused rat kidney.

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概要

• 論文の詳細を見る

• Direct renal effects of angiotensin I converting enzyme inhibitors (CEIs), captopril, SA446 and MK421, were examined in isolated rat kidneys perfused with a renin-substrate-free medium. Among three GEIs, only captopril induced a significant natriuresis, whereas SA446 and MK421 did not. UKV, renal vascular resistance and creatinine clearance were not affected by any of these GEIs. Renin release from perfused rat kidneys were not influenced by GEIs under the present experimental conditions.These results suggest that among three different types of GEIs, only captopril possesses natriuretic action in the isolated perfused rat kidney and that this action may be independent of its inhibitory action on angiotensin converting enzyme. It is also suggested that these three GEIs themselves do not have a direct effect on the renal vascular bed.

• International Heart Journal刊行会の論文

著者

• SARUTA Takao

  Department of Internal Medicine, School of Medicine, Keio University

• Saruta Takao

  Department Of Clinical Pharmacology Jichi Medical School

• Ogihara Tohru

  Department Of Internal Medicine Hiratsuka City Hospital

• Yasui Toshiyuki

  Department Of Electronic Science And Engineering Kyoto University

• Nakane Haruyuki

  Departments Of Internal Medicine School Of Medicine Keio University

• YOSHIZAWA Mamoru

  Department of Internal Medicine, School of Medicine, Keio University

• NAKANE Yoko

  Department of Internal Medicine, Urawa City Hospital

• OGIHARA Tohru

  Department of Internal Medicine, School of Medicine, Keio University

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