EFFECTS OF CALCIUM LOADING IN DOCA-SALT HEPERTENSIVE RATS
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概要
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The effects of oral calcium loading on blood pressure (BP) of DOCA (deoxy-corticosterone acetate)-salt hypertensive rats (D-S rats) were investigated. Calcium loading was performed by adding 1% CaCl_2 (calcium chloride) to the drinking water. Calcium loading attenuated the development of high BP in D-S rats, and at the end of a two week experiment, BP was 141 ± 3 (calcium treated) vs. 174 ± 7 mmHg (non-calcium treated) (p<0.01). However, calcium loading did not cause any changes in BP in normotensive rats. Further, in established D-S rats [after four weeks of DOCA and 1% NaCl (sodium chloride) treatment], calcium loading for 4 weeks also reduced BP [144 ± 6 (calcium treated) vs. 181 ± 4 mmHg (non-calcium treated), p<0.01, at the end of experiment]. With calcium treatment, there were no significant changes in sodium-water balance, plasma levels of epinephrine and norepinephrine, plasma renin activity, plasma aldosterone concentration and serum electrolytes both in developing and established D-S rats. The depressor mechanism of calcium loading was studied by observing vascular responsiveness to norepinephrine both in whole body and in hind limb preparations. Vascular reactivity in both developing and established D-S rats was significantly attenuated by calcium treatment. These results suggest that the antihypertensive effects of calcium treatment in D-S rats are mainly caused by attenuation of vascular reactivity.
- 社団法人日本循環器学会の論文
- 1987-11-20
著者
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SARUTA Takao
Department of Internal Medicine, School of Medicine, Keio University
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Suzuki Hiromichi
慶応義塾大学 内
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Suzuki Hiromichi
Department Of Nephrology Saitama Medical School
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Kageyama Yo
Department Of Internal Medicine School Of Medicine Keio University
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Suzuki Hiromichi
Department Of Internal Medicine School Of Medicine Keio University
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Saruta Takao
Department Of Clinical Pharmacology Jichi Medical School
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Kageyama Yo
Department Of Internal Medicine Keio University
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KONDO KAZUOKI
Departments of Internal Medicine,School of Medicine, Keio University
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Suzuki H
Department Of Internal Medicine School Of Medicine Keio University
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ARIMA Koichiro
Department of Internal Medicine,Kawasaki Municipal Hospital
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Kondo Kazuoki
Department Of Clinical Pharmacology Jichi Medical Schcol
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Suzuki Hiromichi
Department Of Applied Physics Faculty Of Science Fukuoka University
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Kondo K
Department Of Internal Medicine School Of Medicine Keio University
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Kondo Kazuoki
Departments Of Internal Medicine School Of Medicine Keio University
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Suzuki H
Department Of Nephrology Saitama Medical School
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Arima Koichiro
Department Of Internal Medicine Kawasaki Municipal Hospital
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Arima Koichiro
Department Of Internal Medicine School Of Medicine Keio University
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