Effects of Intracerebroventricular Administration of Prostaglandin D2 and Angiotensin II on Blood Pressure in Conscious Rats
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the role of brain prostaglandins in the regulation of blood pressure, we examined the effects of intracerebroventricular injections of prostaglandin D2, angiotensin II and indomethacin on blood pressure in conscious rats. Intraventricular administration of prostaglandin D2, the major prostaglandin synthesized in the rat brain, did not elicit a significant change in blood pressure. On the other hand, intraventricular injection of angiotensin II resulted in an increase in blood pressure in a dose-related manner. However, this central pressor effect of angiotensin II was not affected by intraventricular pretreatment with indomethacin. Indomethacin per se did not induce any change in blood pressure. These results suggest that prostaglandin D2 in the brain does not play an important role in the regulation of blood pressure in conscious rats. It is also suggested that the central pressor effect of angiotensin II is not mediated by prostaglandin biosynthesis in the central nervous system.
- International Heart Journal刊行会の論文
著者
-
SARUTA Takao
Department of Internal Medicine, School of Medicine, Keio University
-
Ebihara Akio
Department of Clinical Pharmacology, Medical College of Oita
-
Saruta Takao
Department Of Clinical Pharmacology Jichi Medical School
-
KONDO KAZUOKI
Departments of Internal Medicine,School of Medicine, Keio University
-
Kondo Kazuoki
Department Of Clinical Pharmacology Jichi Medical Schcol
-
Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
-
EBIHARA Akio
Department of Clinical Pharmacology, Jichi Medical School
関連論文
- The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
- A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension : the REZALT study
- Effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease : subanalysis of the CASE-J Study
- Effects of Cardiac Complications on Cardiovascular Events in Japanese High-Risk Hypertensive Patients : Subanalysis of the CASE-J Trial
- Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications : a sub-analysis of the CASE-J trial
- Role of diabetes and obesity in outcomes of the candesartan antihypertensive survival evaluation in Japan (CASE-J) trial
- 1 Which Risk Factor Has an Adverse Effect on Coronary Events in Japanese High-risk Hypertensive Patients? : a Subanalysis of CASE-J(Comprehensive Risk Management for Prevention of Coronary Artery Disease,Symposium 16 (SY-16) (H),The 73rd Annual Scientific
- Effect of heart rate on the risk of developing metabolic syndrome
- Decreased body mass index as an independent risk factor for developing chronic kidney disease
- ROLE OF AUTONOMIC NERVOUS BLOOD PRESSURE VARIABILITY : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
- Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients : Rationale, Design, and Methods
- Adult T-cell Leukemia with Hypercalcemia-induced Metastatic Calcification in the Lungs Due to Production of Parathyroid Hormone-related Protein
- Valsartan in Elderly Isolated Systolic Hypertension (VALISH) Study : Rationale and Design
- Spironolactone in Combination with Cilazapril Ameliorates Proteinuria and Renal Interstitial Fibrosis in Rats with Anti-Thy-1 Irreversible Nephritis
- Impaired Nitric Oxide-Independent Dilation of Renal Afferent Arterioles in Spontaneously Hypertensive Rats
- Monosynaptic Excitatory Connection from the Rostral Ventrolateral Medulla to Sympathetic Preganglionic Neurons Revealed by Simultaneous Recordings
- The Mechanism of Estrogen Hypertension
- How to manage refractory hypertension
- A Functional Thyrotropin-and Growth Hormone-Secreting Pituitary Adenoma with a Ultrastructurally Monomorphic Feature:A Case Study
- IgG1 Is the Dominant Subclass of Antibody against Glutamic Acid Decarboxylase among Type 1 Diabetes in Japanese
- Autoantibody against IA-2 Improves the Test Sensitivity for Insulin-Dependent Diabetes Mellitus in Japanese Patients of Child Onset
- Glutamic Acid Decarboxylase65 (GAD65) Antibodies and Insulin Auto-Antibodies in Japanese Patients with Non-Insulin-Dependent Diabetes Mellitus
- Antibodies to the 37,000-Mr Tryptic Fragment of Islet Antigen were Detected in Japanese Insulin-Dependent Diabetes Mellitus Patients
- Nitric Oxide Is lmportant for Mouse Beta-Cell Line Killing by Peritoneal Exudate Cells Obtained from Cyclophosphamide Treated Non-Obese Diabeitc Mice
- -433- CARDIOVASCULAR EFFECTS OF INTRAVENOUS AND INTRACORONARY ADMINISTRATION OF ATRIAL NATRIURETIC PEPTIDE IN HALOTHANE ANESTHETIZED DOGS
- Prevention and regression of hypertension : role of renal microvascular protection
- Developmental Activity of the Renin-Angiotensin System during the "Critical Period" Modulates Later L-NAME-Induced Hypertension and Renal Injury
- Comparison of Health Costs Associated with Treatment of Hypertension with a Calcium Channel Blocker and Angiotensin-Converting Enzyme Inhibitor in the United States and Japan
- Glomerulonephritis with microtubular deposits associated with cryoglobulinemia and chronic active hepatitis
- Effects of AT1 Receptor Antagonist on Proteoglycan Gene Expression in Hypertensive Rats
- Plasma Aldosterone Concentrations Are Not Related to the Degree of Angiotensin-Converting Enzyme Inhibition in Essential Hypertensive Patients
- Different role of angiotensin II type 1 and type 2 receptors in renin release by interaction of angiotensin II and renal sympathetic nerve
- Modulation of Angiotensin II Type 1 Receptor mRNA Expression in Human Blood Cells: Comparison of Platelets and Mononuclear Leucocytes
- -1241-EFFECTS OF VASOACTIVE SUBSTANCES ON COLLAGEN SYNTHESIS IN CULTURED VASCULAR SMOOTH MUSCLE CELLS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -P111-EFFECTS OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) ON SYSTEMIC AND RENAL HEMODYNAMICS IN CONSCIOUS DOGS : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Genetic effects on circadian rhythm of heart rate in twins reared apart
- EFFECTS OF VERAPAMIL ON DIGOXIN KINETICS AND INTRAERYTHROCYTE DIGOXIN CONCENTRATION : Heart Failure, Cardiovascular Drugs (I) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- Hyperglycemia Decreases Dehydroepiandrosterone in Japanese Male with Impaired Glucose Tolerance and Low Insulin Response
- A 35-year-old Man with Cerebral Hemorrhage and Pheochromocytoma : The Second Brain-dead Organ Donor in Japan
- Long-Term Effects of Doxazosin, an Alpha_1-Blocker, on Serum Lipids in Hypertensive Patients
- Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design
- Effects of Leptin Receptor Gene 3'-untranslated Region Polymorphism on Metabolic Profiles in Young Japanese Men
- Insulin Resistance and Hypertension : Seven-Year Follow-Up Study in Middle-Aged Japanese Men (the KEIO Study)
- Effects of Body Weight Control on Changes in Blood Pressure : Three-Year Follow-Up Study in Young Japanese Individuals
- Participation in School Sports Clubs and Related Effects on Cardiovascular Risk Factors in Young Males
- Sexual Differences in Relationships between Birth Weight or Current Body Weight and Blood Pressure or Cholesterol in Young Japanese Students
- Supplement. Obesity, Hypertension, Insulin Resistance and Lipid Disorders : Cross-sectopnal and Longitudinal Studies in Japanese Adolescents and Middle-aged Men
- Insulin Resistance Syndrome in Adolescents and Adults
- OE-015 Peripheral Blood Level of Matrix Metalloprotease-9 is Elevated in Patients with Acute Aortic Dissection(Emergency care-1 (H) OE3,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Candesartan and Amlodipine Reduced the High Linearity and Increased the Low Linearity of Cardiovascular Regulation in Spontaneously Hypertensive Rats
- Candesartan Can Reduce Cardiovascular Events by Decreasing Sympathetic Nerve Activity and Plasma Aldosterone
- Difference in the Incidence of Cough Induced by Angiotensin Converting Enzyme Inhibitors: a Comparative Study Using Imidapril Hydrochloride and Enalapril Maleate
- Role of Asymmetrical Dimethylarginine in Renal Microvascular Endothelial Dysfunction in Chronic Renal Failure with Hypertension
- Distinct Modulation of Superficial and Juxtamedullary Arterioles by Prostaglandin in Vivo
- Tolerability and Safety of a Calcium Channel Blocker in Comparison with a Diuretic in the Treatment of Elderly Ptients with Hypertension : Secondary Analysis of the NICS-EH
- RENIN RELEASE AND THE JUXTAGLOMERULAR APPARATUS IN CHRONIC RENAL FAILURE DUE TO GLOMERULONEPHRITIS
- Effects of Angiotensin III (DES-1-Asp-Angiotensin II) and Angiotensin III Analogue (DES-1-Asp-8-Ile-Angiotensin II) upon Adrenal Steroidogenesis and Blood Pressure
- Angiotensinase Activity Using Human Crude Angiotensin
- Primary Malignant Hepatic Pheochromocytoma with Negative Adrenal Scintigraphy
- Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats : Studies in the isolated perfused hydronephrotic kidney
- Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury : Role of Rho-Kinase in the Development of Renal Injury
- Pathophysiological Significance of T-type Ca^ Channels : Role of T-type Ca^ Channels in Renal Microcirculation
- Pioglitazone Lowers Systemic Asymmetric Dimethylarginine by Inducing Dimethylarginine Dimethylaminohydrolase in Rats
- PJ-147 ADMA and DDAH as Determinants of Coronary Endothelial Dysfunction in Early-stage CRF(Endothelium/NO 2 (H) : PJ25)(Poster Session (Japanese))
- Antihypertensive Efficacy and Safety of Fixed-Dose Combination Therapy with Losartan plus Hydrochlorothiazide in Japanese Patients with Essential Hypertension
- Effect of Education through a Periodic Newsletter on Persistence with Antihypertensive Therapy
- Differing Anti-Proteinuric Action of Candesartan and Losartan in Chronic Renal Disease
- Use of Gadolinium Contrast Adrenal Venography for the Assessment of Primary Aldosteronism in a Patient with Iodine Allergy
- Effects of Angiotensin Inhibitors on Renal Injury and Angiotensin Receptor Expression in Early Hypertensive Nephrosclerosis
- Effects of Hemoperfusion Plus High-Flux Hemodialysis in a Patient with Methotrexate Toxicity
- Combination Therapy with Aldosterone Blockade and Renin-Angiotensin Inhibitors Confers Organ Protection
- High Serum Level of Procollagen Type III Amino-Terminal Peptide Contributes to the Efficacy of Spironolactone and Angiotensin-Converting Enzyme Inhibitor Therapy on Left Ventricular Hypertrophy in Essential Hypertensive Patients
- Effects of Spironolactone and Angiotensin-Converting Enzyme Inhibitor on Left Ventricular Hypertrophy in Patients with Essential Hypertension
- -485- THE EFFECT OF THE BILE ACIDS ON THE VASCULAR RESISTANCE
- Effects of the angiotensin II type 1 receptor antagonist candesartan, compared with angiotensin-converting enzyme inhibitors, on the urinary excretion of albumin and type IV collagen in patients with diabetic nephropathy
- Role of intrarenal angiotensin II in glucocorticoid-induced renal vasodilation
- Effect of Combination Therapy of Angiotensin-Converting Enzyme Inhibitor plus Calcium Channel Blocker on Urinary Albumin Excretion in Hypertensive Microalubuminuric Patients with Type II Diabetes
- Malignant Hypertension in a Patient with Primary Aldosteronism with Elevated Active Renin Concentration
- Clinical Efficacy of a New Angiotensin II Type 1 Receptor Blocker, Pratosartan, in Hypertensive Patients
- Angiotensin II Type 2 Receptor Inhibits Prorenin Processing in Juxtaglomerular Cells
- Transmural Pressure Control of Prorenin Processing and Secretion in Diabetic Rat Juxtaglomerular Cells
- Intensive Blood-Pressure Lowering Effects on Arterial Wall Stiffness in Hypertensive Patients
- Chronic administration of fluvastatin prevents development of arterial stiffness in type 2 diabetic patients with end-stage renal disease
- The Mechanism of Low-renin Hypertension : Aldosterone Response to Sodium Restriction and Upright Posture, Angiotensin II, ACTH and Potassium in Patients with Hypertension
- EFFECTS OF CALCIUM LOADING IN DOCA-SALT HEPERTENSIVE RATS
- Effects of Magnesium on the Vasoconstrictor Responses to Norepinephrine and Potassium Chloride in the Rat Mesenteric Artery
- Central and Peripheral Effects of Dopamine on the Renin-Angiotensin-Aldosterone System in Conscious Rats : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Effects of Prostaglandins E_2 and I_2, Arachidonic Acid and Indomethacin on Vascular Reactivity to Norepinephrine in the Rat : IX Conference on the Pathogenesis of Hypertension
- Pharmacokinetics of vancomycin in patients with multiple organ failure during continuous hemodiafiltration
- A VARIOUS METHODS FOR EVALUATING ANTIARRHYTHMIC DRUG EFFECT USING VENTRICULAR ARRHYTHMIA REDUCTION ON AMBULATORY ECG : Arrhythmia : 46th Annual Scientific Meeting, Japanese Circulation Society
- -471- THE EFFECT OF DILTIAZEM ON PLASMA NIFEDIPINE CONCENTRATION IN HUMAN VOLUNTEERS
- Relative Long-Term Effects of Spironolactone in Conjunction with an Angiotensin-Converting Enzyme Inhibitor on Left Ventricular Mass and Diastolic Function in Patients with Essential Hypertension
- Effects of Intracerebroventricular Administration of Prostaglandin D2 and Angiotensin II on Blood Pressure in Conscious Rats
- Aldosterone-Induced Organ Damage : Plasma Aldosterone Level and Inappropriate Salt Status
- Impact of renal function on cardiovascular events in elderly hypertensive patients treated with efonidipine : Renal Subset Analysis of the Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS)
- Effects of Captopril and Prostaglandin I2 on Vasocnstrictor Responses to Norepinephrine and Potassium Ions in Rat Mesenteric Artery
- Central Hypertensive Actions of Angiotensin I, II and III in Conscious Rats
- The paradoxical adverse effect of verapamil for treating clinical paroxysmal supraventricular tachycardia.
- Effects of angiotensin I converting enzyme inhibitors on the renal excretory function, hemodynamics and renin release in isolated perfused rat kidney.
- Calcium Antagonists Protect against Nephrosclerosis in Partially Nephrectomized Spontaneously Hypertensive Rats