The paradoxical adverse effect of verapamil for treating clinical paroxysmal supraventricular tachycardia.
スポンサーリンク
概要
- 論文の詳細を見る
The intravenous administration of verapamil to 2 patients with paroxysmal supraventricular tachycardia (PSVT) resulted in an induction of PSVT during a programmed electrophysiological stimulation study. Each patient had a documented episode of PSVT. Baseline programmed stimulation studies revealed neither induction of PSVT nor an atrial echo; however, PSVT was induced immediately after injecting verapamil (0.15mg/kg) intravenously in both patients. In 1 patient, the study was repeated 2 days later and similar results were obtained. The serum concentration of verapamil when PSVT was induced was about 80ng/ml in both cases. Clinicians using verapamil should note that this antiarrhythmic drug may aggravate PSVT, depending on critical changes in AV nodal conduction and refractoriness.
著者
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Ebihara Akio
Department of Clinical Pharmacology, Medical College of Oita
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Ito Sukenobu
Department Of Internal Medicine Medical College Of Oita
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Ohmura Ichiro
Department Of Cardiology National Fukuoka Higashi Medical Center
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Ohashi Kyoichi
Department Of Clinical Pharmacology
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Yonemochi Hidetoshi
Department Of Bioclimatology And Medicine Medical Institute Of Bioregulation Kyushu University
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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Inoue Ken
Department Of Electronic Engineering Denki-tsushin University (uec)
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YONEMOCHI Hidetoshi
Department of Medicine, Medical College of Oita
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OHMURA Ichiro
Department of Cardiology, Fukuoka Higashi National Hospital
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Saikawa Tetsunori
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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Nakagawa Mikiko
Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University
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ITO Sukenobu
Department of Medicine, Medical College of Oita
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Ito Morio
Department of Health Care Center, Munakata Ishikai-Hospital
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SAIKAWA Tetsunori
Department of Medicine, Medical College of Oita
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NAKAGAWA Mikiko
Department of Medicine, Medical College of Oita
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