Chronopharmacokinetic Study of a New Immunosuppressive Agent, FK 506, in Mice.
スポンサーリンク
概要
- 論文の詳細を見る
Chronopharmacokinetic profiles of a new immunosuppressive agent, FK 506, were examined in mice. FK 506 (1 mg/kg)was given orally at 10 AM (day trial)or 10 PM (night trial)once a day for 7 days. Blood samples for measurement of FK 506 concentration in whole blood were obtained just before and at 1, 2, 3, 4, 6, 8 and 12 hr after the final dosage. The time to maximum concentration was shorter and the maximum concentration was greater in the night trial than in the day trial. These findings suggest that absorption of FK 506 is faster and its blood concentration is higher in the night trial.
著者
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Shiga Tsuyoshi
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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Ohashi Kyo-ichi
Department of Clinical Pharmacology, Jichi Medical School
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Ebihara Akio
Department of Clinical Pharmacology, Jichi Medical Schoo
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Shiga Tsuyoshi
Department of Clinical Pharmacology, Jichi Medical Schoo
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