Role of Bradykinin in the Reduction of Left Ventricular Hypertrophy Induced by Angiotensin-Converting Enzyme Inhibitors in Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
We examined the effects of icatibant, a specific bradykinin B2-receptor antagonist, on the regression of left ventricular mass (LVM) induced by angiotensin converting enzyme (ACE) inhibitors, ramipril and imidapril, in spontaneously hypertensive rats. Both ramipril and imidapril lowered blood pressure equally, which were not influenced by icatibant. Icatibant did not alter the regressive effect of imidapril, while it showed a tendency to increase LVM in the ramipril-treated rats. The changes of LVM induced by icatibant were significantly different between the ramipril- and the imidapril-treated rats, suggesting that the role of bradykinin in the antihypertrophic effect might differ among ACE inhibitors.
- 1998-04-01
著者
-
Sugimoto Koh-ichi
Department Of Clinical Pharmacology Jichi Medical College
-
Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
-
Sugimoto Koh-ichi
Department Of Clinical Pharmacology Jichi Medical School
関連論文
- Effects of Retained Austenite Parameters on Warm Stretch-flangeability in TRIP-aided Dual-phase Sheet Steels
- Warm Stretch-formability of TRIP-aided Dual-phase Sheet Steels
- Failure of Probucol to Prolong Survival in Salt-Loaded Stroke-Prone Spontaneously Hypertensive Rats
- Retained Austenite Characteristics and Stretch-flangeability of High-stength Low-alloy TRIP Bainitic Sheet Steels
- Effects of Renin-Angiotensin System Blockade and Dietary Salt Intake on Left Ventricular Hypertrophy in Dahl Salt-Sensitive Rats
- -0958- Age Dependent Increase in Plasma Angiotensinogen and Enhanced Expression of Angiotensinogen mRNA in Heart and Aorta of Wistar Fatty Hypertensive Rats(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0704- Salt Depletion with Renin-Angiotensin System Blockade Markedly Regressed Left Ventricular Hypertrophy in Dahl Salt-Sensitive Rats(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- EFFECTS OF ANGIOTENSIN II RECEPTOR ANTAGONISTS,LISARTAN AND TCV 116, ON CARDIOVASCULAR HYPERTROPHY IN SALTLOADED DAHL SALT-SENSETIVE RATS
- ECHOCARDIOGRAPHIC ASSESSMENT OF THE EFFECTS OF SHORT-TERM TREATMENT WITH CERONAPRIL(SQ-29,852)ON CARDIAC FUNCTION IN PATIENTS EITH ESSENTIAL HYPERTENSION
- Genetic effects on circadian rhythm of heart rate in twins reared apart
- EFFECTS OF VERAPAMIL ON DIGOXIN KINETICS AND INTRAERYTHROCYTE DIGOXIN CONCENTRATION : Heart Failure, Cardiovascular Drugs (I) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- Different Effects of Imidapril and Enalapril on Aminopeptidase P Activity in the Mouse Trachea
- Effect of Intraperitoneal Neutrophils Induced by OK432 on Malignant Ascites
- A Comparative Pharmacology Study Between the Intracolonic and Oral Routes of 5-FU Administration in a Colon Cancer-Bearing Yoshida Sarcoma Rat Model
- Sustained Plasma Fibrinogen Elevation in Subtotal Nephrectomized Rats : Effect of Cilazapril, an Angiotensin-Converting Enzyme Inhibitor
- Pravastatin Prevents Arrhythmias Induced by Coronary Artery Ischemia/Reperfusion in Anesthetized Normocholesterolemic Rats
- Vasoconstricting Effect of Angiotensin II in Human Hand Veins : Influence of Aging, Diabetes Mellitus and Hypertension
- Dosing Time-Dependent Effect of Trandolapril on the Prevention of Cardiac Hypertrophy in Rats With Aortic Banding
- Effect of Prolonged Nitric Oxide Synthesis Inhibition on Plasma Fibrinogen Concentration in Rats
- RAT ORGAN TRANSPLANTATION USING CUFF ANASTOMOSIS
- A Comparison of the Antagonistic Activities of Tamsulosin and Terazosin Against Human Vascular α_1-Adrenoceptors
- Changes in fecal fat excretion from allo-intestine transplanted rats after discontinuance of immunosuppressive agents
- Alleviation of Nephropathy Induced by Immunosuppressive Agents
- Levothyroxine-Induced Liver Dysfunction in a Primary Hypothyroid Patient
- Effect of Amezinium Metilsulfate on the Finger Skin Vasoconstrictor Response to Cold Stimulation and Venoconstrictor Response to Noradrenaline
- Timing of Lymphocyte Transfusion and Portal Clamping for the Development of Lethal Graft-versus-Host Disease in the Rat
- Endoscopic findings in transplanted allo-intestine of rats after discontinuance of immunosuppressive agent
- Role of Bradykinin in the Reduction of Left Ventricular Hypertrophy Induced by Angiotensin-Converting Enzyme Inhibitors in Spontaneously Hypertensive Rats
- Effect of Probenecid and Ranitidine on Urinary Excretion of Lomefloxacin in Rats
- P486 Effect of amezinium and midodrine on vasoconstrictor response to sympathetic stimulation.
- Long-Term Effects of Doxazosin, an Alpha_1-Blocker, on Serum Lipids in Hypertensive Patients
- Generation of Large Volume Hydrostatic Pressure to 8 GPa for Ultrasonic Studies
- Fractal dimensions of fracture surfaces of rock fragments
- Preferred orientation of phyllosilicates in Yamato-74642 and -74662, in relation to deformation of C2 chondrites
- A Comparative Pharmacology Study Between the Intracolonic and Oral Routes of 5-FU Administration in a Colon Cancer-Bearing Yoshida Sarcoma Rat Model
- Long-Term Therapy with an ACE Inhibitor, Temocapril, Reduces Microalbuminuria in Essential Hypertension
- Microstructure and Formability of Aluminum Bearing TRIP-Aided Steels with Annealed Martensite Matrix
- Effects of Nb and Mo Addition to 0.2%C-1.5%Si-1.5%Mn Steel on Mechanical Properties of Hot Rolled TRIP-aided Steel Sheets
- Ductility and Formability of Newly Developed High Strength Low Alloy TRIP-aided Sheet Steels with Annealed Martensite Matrix
- Microstructure and Formability of Aluminum Bearing TRIP-Aided Steels with Annealed Martensite Matrix
- Effect of YAG Laser Cutting on Stretch-flangeability of Ultra High Strength TRIP Sheet Steel with Bainitic Ferrite Matrix
- Characteristics of Clinical Trials Conducted in Japan under the New GCP Guideline : Analysis of PMDA Audit Reports
- Assessing Aptitude of Plated Ni–W Film as Mold Materials for Borosilicate Glass
- Stretch-flangeability of a High-strength TRIP Type Bainitic Sheet Steel
- Retained Austenite Characteristics and Tensile Properties in a TRIP Type Bainitic Sheet Steel
- Effects of the Addition of Cr, Mo and Ni on the Microstructure and Retained Austenite Characteristics of 0.2% C–Si–Mn–Nb Ultrahigh-strength TRIP-aided Bainitic Ferrite Steels
- Chronopharmacokinetic Study of a New Immunosuppressive Agent, FK 506, in Mice.
- Fabrication of Glassy Carbon Molds Using Hydrogen Silsequioxane Patterned by Electron Beam Lithography as O2 Dry Etching Mask
- Frequency of Prescriptions that could Cause Harmful Drug Interactions and Usefulness of Providing such Information.
- Microstructure and Retained Austenite Characteristics of Ultra High-strength TRIP-aided Martensitic Steels
- Chronopharmacology of Trichlormethiazide in Rats: (III). Influence on Serum Triglyceride and Glucose.
- Influence of Chronic Lithium Treatment on Urinary Amount of Furosemide in Rats.
- Diurnal Variation in the Diuretic Effects of Nitrendipine in Saline Loaded Rats.
- Chronopharmacology of Probucol in Mice.
- Influence of Adrenalectomy on Chronopharmacological Phenomenon of Furosemide in Rats.
- Chronopharmacology of the New Uricosuric Diuretic S-8666 in Rats:(II)Examination in Aged Rats.
- Daily Variation in the Effects of Furosemide in Rats.
- Chronopharmacology of trichlormethiazide in rats.
- Influence of .ALPHA.-Receptor Blockade on the Time-Dependent Change in the Effect of Furosemide.
- Chronopharmacology of the New Uricosuric Diuretic S-8666 in Rats.
- Administration Time-Dependent Change in the Effect of Spironolactone in Rats.
- Influence of Repeated Administration of Lithium on Urinary Excretion of Prostaglandins in Rats.
- Influence of captopril on the diuretic effects of furosemide in healthy subjects; A preliminary study.
- Chronopharmacology of Furosemide in Rats with Amikacin-Induced Acute Renal Damage.
- Effects of Volume Fraction and Stability of Retained Austenite on Ductility of TRIP-aided Dual-phase Steels.
- Effects of the Addition of Cr, Mo and Ni on the Microstructure and Retained Austenite Characteristics of 0.2% C-Si-Mn-Nb Ultrahigh-strength TRIP-aided Bainitic Ferrite Steels