Dosing Time-Dependent Effect of Trandolapril on the Prevention of Cardiac Hypertrophy in Rats With Aortic Banding
スポンサーリンク
概要
- 論文の詳細を見る
Trandolapril was given to male Wistar rats with aortic banding at 10 AM or 10 PM for 6 weeks to examine the influence of dosing time on the development of left ventricular mass (LVM). Aortic banding increased the LVM compared with the sham-operated animals (P<0.01). Trandolapril (1 mg/kg) at 10 AM reduced LVM (1.74 ± 0.04 [S.E.M.] mg/g) more than the dosing at 10 PM (1.92 ± 0.04 mg/g, P<0.05), suggesting that trandolapril has a dosing time-dependent effect in the prevention of cardiac hypertrophy in rats with aortic banding.
- 2001-09-01
著者
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Sugimoto Koh-ichi
自治医科大学 臨床薬理学
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Sugimoto K
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
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Sugimoto Koh-ichi
Department Of Clinical Pharmacology Jichi Medical College
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Fujimura A
Jichi Medical School Tochigi Jpn
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Fujimura Akio
自治医科大学 薬理学
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Fujimura Akio
Institute Of Space And Astronautical Sciences
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KAWAGUCHI Atsuhiro
Department of Clinical Pharmacology, Jichi Medical School
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Kawaguchi Atsuhiro
Department Of Clinical Pharmacology Jichi Medical School
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TSURUOKA Shuichi
Department of Pharmacology, Division of Clinical Pharmacology, Jichi Medical University School of Me
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OHMORI Masami
Department of Clinical Pharmacology, Jichi Medical School
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TSURUOKA Shuichi
the Department of Clinical Pharmacology, Jichi Medical School
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Tsuruoka Shuichi
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
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Tsuruoka Shuichi
Department Of Clinical Pharmacology Jichi
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Sugimoto Koh-ichi
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
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Fujimura Akio
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
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Ohmori Masami
Department Of Clinical Pharmacology Jichi Medical School
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Sugimoto K
Dept. Mech. Syst. Engng. Shinshu Univ.
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