Effect of Prolonged Nitric Oxide Synthesis Inhibition on Plasma Fibrinogen Concentration in Rats
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概要
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We examined whether nitro-L-arginine-methyl ester (L-NAME) causes a sustained elevation in plasma fibrinogen concentration in rats. Oral dosing of L-NAME (100 mg/kg per day) for 7 days significantly raised plasma fibrinogen concentration in rats. The increase in plasma fibrinogen, however, returned to control levels by the treatment for more than 7 days, in spite of progressive hypertension. Candesartan failed to reverse the transient hyperfibrinogenemia, indicating that the rise in plasma fibrinogen may occur through the mechanisms other than angiotensin II receptor activation. These data suggest that a prolonged L-NAME treatment does not cause chronic hyperfibrinogenemia in rats.
- 2001-01-01
著者
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Sugimoto Koh-ichi
自治医科大学 臨床薬理学
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Sugimoto K
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
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Sugimoto Koh-ichi
Department Of Clinical Pharmacology Jichi Medical College
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Fujimura A
Jichi Medical School Tochigi Jpn
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Fujimura Akio
自治医科大学 薬理学
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
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Fujimura Akio
Institute Of Space And Astronautical Sciences
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TSURUOKA Shuichi
Department of Pharmacology, Division of Clinical Pharmacology, Jichi Medical University School of Me
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TSURUOKA Shuichi
the Department of Clinical Pharmacology, Jichi Medical School
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Tsuruoka Shuichi
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
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Tsuruoka Shuichi
Department Of Clinical Pharmacology Jichi
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Sugimoto Koh-ichi
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
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Fujimura Akio
Department Of Pharmacology Division Of Clinical Pharmacology Jichi Medical School
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Sugimoto K
Dept. Mech. Syst. Engng. Shinshu Univ.
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