Daily Variation in the Effects of Furosemide in Rats.
スポンサーリンク
概要
- 論文の詳細を見る
Daily variation in the effects of furosemide, a loop diuretic agent, was examined in Wistar rats maintained under conditions of light from 7 a.m. to 7 p.m. and dark from 7 p.m. to 7 a.m. Furosemide (30 mg/kg) was given orally at 12 p.m., 4 a.m., 8 a.m., 12 a.m., 4 p.m. or 8 p.m. Urine was collected for 8 hr after furosemide administration, and urinary excretions of sodium and furosemide were determined. There were significant daily variations in the urine volume and urinary excretions of sodium and furosemide with a peak at 8 a.m. and a trough at 12 p.m. Significant correlations were observed between the urinary amount of furosemide and its diuretic effects (urine volume and urinary sodium excretion). These results suggest that the diuretic effects of furosemide show daily variations which are, at least in part, caused by the daily variation in the urinary excretion of furosemide.
- 公益社団法人 日本薬理学会の論文
著者
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Fujimura Akio
Department Of Clinical Pharmacology Jichi Medical School
-
Shiga Tsuyoshi
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Ebihara Akio
Department Of Clinical Pharmacology Jichi Medical School
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Sudoh Toshiaki
Department Of Clinical Pharmacology Jichi Medical School
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Ohashi Kyo-ichi
Department of Clinical Pharmacology, Jichi Medical School
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